The delivery of chemical messenger (neurotransmitter) receptors to the junctions between nerve cells (synapses) is crucial to cognitive processes such as memory. One way of understanding the function of these receptors is ...
Feb 22, 2017
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Receptors on the surface of our cells enable a wide variety of functions from our sense of smell to memory.
Jan 24, 2017
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Researchers at UT Southwestern Medical Center have identified a previously unknown role of a cellular signaling molecule involved in release of the "hunger hormone" ghrelin, a finding that could have implications for optimal ...
Aug 22, 2016
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Reprogramming of the molecular pathways underlying normal metabolism is essential for T cell infection-fighting function and for the immune system to form a "memory" of the microbes it has already encountered. But exactly ...
Aug 2, 2016
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Multiple sclerosis (MS) is an autoimmune disorder that results in demyelination of neurons. The FDA-approved drug fingolimod (Gilenya, FTY-720) modulates signaling by the bioactive lipid sphingosine-1-phosphate (S1P), which ...
Jun 16, 2016
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When the body is fighting an invading pathogen, white blood cells—including T cells—must respond. Now, Salk Institute researchers have imaged how vital receptors on the surface of T cells bundle together when activated.
Jun 15, 2016
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The next generation of drugs to tackle two of the planet's biggest killers are to be developed through a partnership bringing together powerful Nobel Prizewinning imaging technology and some of the brightest scientific ...
May 12, 2016
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About thirty percent of all medical drugs such as beta-blockers or antidepressants interact with certain types of cell surface proteins called G protein coupled receptors. In collaboration with researchers from the Paul Scherrer ...
Feb 3, 2016
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Researchers at the Virginia Bioinformatics Institute at Virginia Tech have uncovered key cellular functions that help regulate inflammation—a discovery that could have important implications for the treatment of allergies, ...
Aug 27, 2015
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T cells are the guardians of our bodies: they constantly search for harmful invaders and diseased cells, ready to swarm and kill off any threats. A better understanding of these watchful sentries could allow scientists to ...
Aug 3, 2015
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