Diseases, Conditions, Syndromes

Mortality highest for Asians, Hispanic/Latinos with lupus

(HealthDay)—Standardized mortality ratios (SMRs) of observed-to-expected deaths are increased for patients with systemic lupus erythematosus (SLE) and are especially high for Asians and Hispanic/Latinos, according to research ...

Immunology

When hyperactive proteins trigger illnesses

The immune system can be a mixed blessing: Usually it is highly effective in protecting the human organism against bacteria, viruses and mycosis and even cancer. But these defense cells can also turn against the body's own ...

Inflammatory disorders

Some inflammatory diseases linked to stroke-associated pneumonia

(HealthDay)—For patients discharged after acute ischemic stroke (AIS), the risk for stroke-associated pneumonia (SAP) is reduced for those with psoriasis or other chronic inflammatory diseases, according to a study published ...

Immunology

A new approach to study autoimmune diseases

A team of researchers led by the Indiana Biosciences Research Institute Diabetes Center's Scientific Director Decio L. Eizirik, MD, Ph.D., has found that identifying new treatments for autoimmune diseases requires studying ...

Cardiology

Black patients with lupus have three times higher risk of stroke

New research reveals that, in the U.S., Black patients with lupus have a threefold higher risk of stroke and a 24-fold higher risk of ischemic heart disease. The study also found several lupus-specific symptoms that predict ...

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Systemic lupus erythematosus

Systemic lupus erythematosus (SLE or lupus, pronounced sɪˈstɛmɪk ˈluːpəs ˌɛrəˌθiməˈtoʊsəs (help·info)) is a chronic autoimmune connective tissue disease that can affect any part of the body. As occurs in other autoimmune diseases, the immune system attacks the body’s cells and tissue, resulting in inflammation and tissue damage.

SLE most often harms the heart, joints, skin, lungs, blood vessels, liver, kidneys, and nervous system. The course of the disease is unpredictable, with periods of illness (called flares) alternating with remissions. The disease occurs nine times more often in women than in men, especially between the ages of 15 and 50, and is more common in those of non-European descent.

SLE is treatable through addressing its symptoms, mainly with corticosteroids and immunosuppressants; there is currently no cure. SLE can be fatal, although with recent medical advances, fatalities are becoming increasingly rare. Survival for people with SLE in the United States, Canada, and Europe is approximately 95% at five years, 90% at 10 years, and 78% at 20 years.

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