Neuroscience

Genetic screen offers new drug targets for Huntington's disease

Using a type of genetic screen that had previously been impossible in the mammalian brain, MIT neuroscientists have identified hundreds of genes that are necessary for neuron survival. They also used the same approach to ...

Oncology & Cancer

Body's natural signal carriers can help melanoma spread

A new study from Finland sheds fresh light on how melanoma cells interact with other cells via extracellular vesicles they secrete. The researchers found that extracellular vesicles secreted by melanoma cells use the so-called ...

Oncology & Cancer

Cancer research: The genetic context is crucial

A team at Ludwig-Maximilians-Universitaet (LMU) in Munich has uncovered a mechanism behind the variability in the clinical course of Ewing sarcoma. The interaction between the acquired driver mutation and the germline genetic ...

Medical research

Research discovers inhibitor to reverse toxic DUX4 effects

About one in 8,000 people have facioscapulohumeral muscular dystrophy, according to a 2014 study, which is relatively common in the world of genetic diseases. New University of Minnesota Medical School research identifies ...

Oncology & Cancer

Cancer susceptibility genes

Genome-wide association studies (GWASs) have identified hundreds of genetic "risk" variants for human cancers. The vast majority likely contribute to cancer development by regulating the expression of other genes, but these ...

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