Alzheimer's disease & dementia

Alzheimer's study shows promise in protecting brain from tau

In the wake of recent disappointments over clinical trials targeting amyloid plaque build-up in Alzheimer's disease, researchers are focusing more attention on misfolded tau protein, another culprit in brain diseases that ...

Neuroscience

Protein movement in cells hints at greater mysteries

A new imaging technique that makes it possible to match motor proteins with the cargo they carry within a cell is upending a standard view of how cellular traffic reaches the correct destination. The research, which focuses ...

Medical research

How to enable light to switch on and off therapeutic antibodies

When antigens such as a virus or bacteria invade our body, the immune system springs into action: it creates antibodies that stick to the antigens so that they can identify and destroy the intruders. Did you know that these ...

Medical research

Scientists enlist tiny biomagnets for faster drug discovery

What started as a hallway conversation between colleagues is now an "engine for the discovery of new therapeutic targets in cells" thanks to Medicine by Design, says Shana Kelley, a University Professor in the Leslie Dan ...

Medical research

Novel paradigm in drug development

Traditional medicines mostly function as inhibitors, attacking the disease-relevant proteins that cause cancer, by binding to their accessible pockets. Following this strategy, only ~20% of all proteins are chemically addressable, ...

Neuroscience

Brain signaling proteins hit the road running

Surprisingly complex movements in an important neurotransmitter receptor may help explain the brain's unpredictable response to drugs, according to a new study. New research from an international team, published this week ...

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