Alzheimer's disease & dementia

Tau protein changes correlate with Alzheimer's disease dementia stage

Research into Alzheimer's disease has long focused on understanding the role of two key proteins, beta amyloid and the tau protein. Found in tangles in patients' brain tissue, a pathological form of the tau protein contributes ...

Genetics

Cause of Alzheimer's disease traced to mutation in common enzyme

Researchers from Tokyo Metropolitan University have discovered a new mechanism by which clumps of tau protein are created in the brain, killing brain cells and causing Alzheimer's disease. A specific mutation to an enzyme ...

Alzheimer's disease & dementia

Brain regions with impaired blood flow have higher tau levels

In Alzheimer's disease, impaired blood flow to brain regions coincides with tau protein buildup. This relationship strengthens as cognition declines, according to new research published in JNeurosci.

Genetics

Researchers discover a rare genetic form of dementia

A new, rare genetic form of dementia has been discovered by a team of Penn Medicine researchers. This discovery also sheds light on a new pathway that leads to protein build up in the brain—which causes this newly discovered ...

Neuroscience

New mouse model of tau propagation

Accumulation of assembled tau protein in the central nervous system is characteristic of Alzheimer's disease and several other neurodegenerative diseases, called tauopathies. Recent studies have revealed that propagation ...

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