Genetics

Moving a cardiac regulatory protein to the right place

The largest known protein, titin, named for the Titan giants of Greek mythology, is a molecular spring found in cardiac muscle. It provides structural support and maintains tension during muscle stretching. Mutations in the ...

Medical research

Introducing titin, the protein that rules our hearts

Although scientists have long speculated that a protein named titin measures thick filaments—the proteins that make muscles contract—no one has been able to provide evidence to support their theories.

Medical research

A trigger for muscular diseases

A University of Arizona doctoral candidate has shown for the first time that genetic mutations in the titin gene can cause skeletal muscle myopathy, a disease in which muscle fibers do not function properly, resulting in ...