Cardiology

Newly discovered mechanism regulates myocardial distensibility

A healthy heart beats 50 to 100 times a minute and pumps 8,000 liters of blood around our body every day. A precondition for this function is the elasticity of the cardiac walls, which dilate as blood flows in (diastole) ...

Cardiology

Protein dynamics in the beating heart

The protein titin is a large structural component of the sarcomere—the machinery that mediates contraction of cardiac muscle cells. Despite its importance to the beating heart, little is known about titin turnover.

Medical research

Tracking titin in real time

Using new high-resolution imaging techniques, MDC researchers and colleagues have tracked titin, the body's largest protein, in real time throughout its entire lifecycle. The method and results could provide new insight into ...

Genetics

Moving a cardiac regulatory protein to the right place

The largest known protein, titin, named for the Titan giants of Greek mythology, is a molecular spring found in cardiac muscle. It provides structural support and maintains tension during muscle stretching. Mutations in the ...

Medical research

Introducing titin, the protein that rules our hearts

Although scientists have long speculated that a protein named titin measures thick filaments—the proteins that make muscles contract—no one has been able to provide evidence to support their theories.

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