Scientists at the Centro Nacional de Investigaciones Cardiovasculares (CNIC), in collaboration with an international scientific team, have described a new mechanism of modulation of the mechanical properties of the heart, ...
Apr 27, 2022
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Patients with heart failure often have shortness of breath and become fatigued quickly. They frequently suffer from water retention, heart palpitations, and dizziness. The condition can be triggered by a combination of elevated ...
Dec 1, 2021
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Titin is a "titanically large" protein—the largest in the human body—which enables elastic movements of our muscles, including the heart. Mutations in the titin gene (TTN) that impair this function are the most frequent ...
Nov 5, 2021
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Researchers at Penn Medicine have made a major advance in understanding the biology of a common, puzzling, and often fatal heart disorder, dilated cardiomyopathy (DCM), which features the enlargement of the heart and a progressive ...
Nov 3, 2021
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A healthy heart beats 50 to 100 times a minute and pumps 8,000 liters of blood around our body every day. A precondition for this function is the elasticity of the cardiac walls, which dilate as blood flows in (diastole) ...
Sep 15, 2020
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Critical illness myopathy (CIM) has taken on a new relevance as a result of the corona virus. CIM is the specialists' term for a muscle weakness which occurs in patients being treated in intensive care for a longer period ...
Sep 9, 2020
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The protein titin is a large structural component of the sarcomere—the machinery that mediates contraction of cardiac muscle cells. Despite its importance to the beating heart, little is known about titin turnover.
Dec 18, 2019
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Using new high-resolution imaging techniques, MDC researchers and colleagues have tracked titin, the body's largest protein, in real time throughout its entire lifecycle. The method and results could provide new insight into ...
Dec 13, 2019
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Researchers at the University of Arizona have discovered that metformin, a drug commonly used to treat type 2 diabetes, might also be used to treat heart failure with preserved ejection fraction (HFpEF), a condition that ...
Dec 19, 2018
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In the field of muscle physiology, scientists study muscle movement at the molecular level—chiefly, proteins such as myosin, actin and titin—to understand how muscles contract.
Oct 8, 2018
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