Neuroscience

Discovery puts designer dopamine neurons within reach

For decades, the elusive holy grail in Parkinson's disease research has been finding a way to repair faulty dopamine neurons and put them back into patients, where they will start producing dopamine again. Researchers have ...

Cancer

Mutations in key cancer protein suggest new route to treatments

For years, scientists have struggled to find a way to block a protein known to play an important role in many cancers. The protein, STAT3, acts as a transcription factor—it performs the crucial task of helping convert DNA ...

Medical research

Circadian clock controls insulin and blood sugar in pancreas

A new Northwestern Medicine study has pinpointed thousands of genetic pathways an internal body clock takes to dictate how and when our pancreas must produce insulin and control blood sugar, findings that could eventually ...

Cancer

New computational strategy finds brain tumor-shrinking molecules

Patients with glioblastoma, a type of malignant brain tumor, usually survive fewer than 15 months following diagnosis. Since there are no effective treatments for the deadly disease, University of California, San Diego researchers ...

Neuroscience

Mapping face sensation in the brainstem

Filippo Rijli and his group at the FMI have shown how the formation of a sensory topographic map in the brainstem is controlled by a single transcription factor, thus shedding light on a decades-old question in neuroscience. ...

Medical research

Study shows GATA4 plays a key role in cell senescence

(Medical Xpress)—A team of researchers from Harvard Medical School and Buck Institute for Research on Aging has conducted a study that has revealed that GATA4 (a transcription factor) plays a significant role in cell senescence. ...

Immunology

Epigenomic changes are key to innate immunological memory

A research team led by Keisuke Yoshida and Shunsuke Ishii of the RIKEN Molecular Genetics Laboratory has revealed that epigenomic changes induced by pathogen infections, mediated by a transcription factor called ATF7, are ...

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