A team of researchers led by Professor Megumu K. Saito have undertaken a massive effort to build an induced pluripotent stem (iPS) cell resource for rare diseases, enabling research and development of novel diagnostic tools ...
Oct 5, 2023
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Pancreatic cancer is one of the deadliest forms of cancer. This is largely due to the cancer being detected at a late stage. In addition, treatment options for pancreatic cancer are limited.
Oct 5, 2023
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The microphthalmia-associated transcription factor (MITF) is the master regulator of pigment cell development and, as a lineage survival oncogene, plays a crucial role in the skin cancer melanoma and its resistance to therapy. ...
Oct 2, 2023
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Currently, a lot is known about which genes are responsible for our individual blood groups; however, not much is understood about how and why the levels of the blood group molecules differ between one person and another. ...
Sep 29, 2023
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Among available immunotherapies, the use of CAR T cells is proving extremely effective against certain blood cancers, but only in half of patients. A main reason for this is the premature dysfunction of these immune cells, ...
Sep 20, 2023
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In recent years, scientists have used gene modification technologies to reprogram immune cells into therapeutics that can attack cancers. But such immunotherapies don't work for all patients or all cancer types, and screening ...
Sep 14, 2023
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Chronic kidney disease is a condition in which kidney function declines, causing significant health issues in patients. A previous study led by Dr. Motoko Yanagita found that tertiary lymphoid tissues (TLTs), which develop ...
Aug 31, 2023
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There's no question that tumor cells are notoriously skilled masters of immune disguise and, in many ways, real-life versions of what it's like hiding under the fictional invisibility cloak highlighted in the Harry Potter ...
Using human "mini-brain" models known as organoids, Mayo Clinic and Yale University scientists have discovered that the roots of autism spectrum disorder may be associated with an imbalance of specific neurons that play a ...
Aug 10, 2023
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Immune system T cells that should be able to kill cancer cells become dysfunctional or "exhausted" within hours of encountering a tumor, according to a study reported Aug. 3 in Nature Immunology.
Aug 3, 2023
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