Medical research

Cell death or cancer growth: A question of cohesion

Activation of CD95, a receptor found on all cancer cells, triggers programmed cell death—or does the opposite, namely stimulates cancer cell growth. Scientists from the German Cancer Research Center (DKFZ) have now shown ...

Oncology & Cancer

New candidate cancer genes identified using math models

Computational modeling is the use of computers to simulate and study the behavior of complex systems. Computational approaches are widely adopted in the bioimedical sciences and can be used to sift through large volumes of ...

Oncology & Cancer

Anthrax may be the next tool in the fight against bladder cancer

Anthrax may soon help more people win the fight against bladder cancer, which the Centers for Disease Control and Prevention says strikes about 72,000 Americans each year and kills about 16,000, and is one of the most expensive ...

Oncology & Cancer

Protein decoy stymies lung cancer growth in mice, study finds

Scientists at Stanford and UC-San Francisco have developed an experimental drug that targets a currently untreatable type of lung cancer responsible for generating roughly 500,000 newly diagnosed cases worldwide each year.

Oncology & Cancer

Drug that targets key mutation found to shrink some tumors

A team of researchers affiliated with several institutions in the U.S. and Australia (and sponsored by pharmaceutical company Amgen Research) has found that a drug they optimized to target a protein produced due to mutations ...

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Transforming growth factor

Transforming growth factor (sometimes referred to as Tumor growth factor, or TGF) is used to describe two classes of polypeptide growth factors, TGFα and TGFβ.

The name "Transforming Growth Factor" is somewhat arbitrary, since the two classes of TGFs are not structurally or genetically related to one another, and they act through different receptor mechanisms. Furthermore, they do not always induce cellular transformation, and are not the only growth factors that induce cellular transformation.

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