Researchers at The University of Texas MD Anderson Cancer Center have identified a tenacious subset of immune macrophages that thwart treatment of glioblastoma with anti-PD-1 checkpoint blockade, elevating a new potential ...
Dec 23, 2019
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The prognosis of ovarian cancer is poor, with an estimated five-year survival of only 40% for advanced disease, the stage at which most ovarian carcinomas are diagnosed. These poor outcomes are partly due to the lack of effective ...
Feb 3, 2021
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An experimental drug targeting a common mutation in melanoma successfully shrank tumors that spread to the brain in nine out of 10 patients in part of an international phase I clinical trial report in the May 18 issue of ...
May 17, 2012
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Pancreatic ductal adenocarcinoma (PDAC) cells maintain a high level of autophagy or degradation, allowing them to thrive in severely limiting microenvironments. However, the process via which autophagy promotes pancreatic ...
Cancer, in all its forms, seems to always involve uncontrolled cell growth; but there are thousands of ways in which cells can lose control of their proliferation in the first place. Among a huge variety of proteins known ...
Mar 22, 2019
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Scientists at Joslin Diabetes Center have identified two novel markers that, when elevated in the blood stream, can predict accurately the risk of renal (kidney) failure in patients with Type 1 and Type 2 diabetes. The findings ...
Jan 19, 2012
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One of the main challenges in oncology is the development of drugs against KRAS oncogenes. These oncogenes—genes that cause cancer when mutated—are responsible for a quarter of all human cancers, including the three tumor ...
Sep 1, 2022
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Duke Cancer Institute researchers have identified potential biomarkers that predict the likelihood for checkpoint inhibitor drugs to backfire, driving hyper-progression of melanoma cells instead of unleashing the immune system ...
Nov 23, 2022
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A new Blood Advances study suggests that people with cancer and non-O blood types, such as types A, B, and AB, face an increased risk of developing venous thromboembolism (VTE), or blood clots in the veins, three months ...
Apr 13, 2022
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A study led by the Peter Doherty Institute for Infection and Immunity (Doherty Institute) has found that CD4+ T cells, traditionally called 'helper T cells' for their role in aiding the activation of other immune cells, are ...
Jan 19, 2024
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