Hypoxia-activated prodrugs (HAPs) have the potential to activate specifically in hypoxic tumors and eliminate tumor cells, which has brought new opportunities for safe and effective anticancer therapy. However, their therapeutic ...
Apr 3, 2024
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In a large cohort of patients with common forms of chronic kidney disease (CKD), researchers found that urine-to-plasma ratio of urea ([U/P]urea) was independently associated with CKD progression and kidney failure.
Nov 8, 2022
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The number of elderly suffering from Alzheimer's disease has been rapidly rising over the past decades. For a long time, scientists believed that misfolded aggregates of amyloid-beta protein accumulate and form plaques in ...
Jun 22, 2022
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The urea cycle is responsible for removing nitrogenous waste produced from the breakdown of protein in the organism. If the OTC enzyme is missing in this cycle, ammonia accumulation rises to toxic levels. An OTC deficiency ...
Jan 17, 2022
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More than half of the people in the world host colonies of a bacterium called Helicobacter pylori in their stomachs.
Mar 26, 2019
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Synlogic, Inc., a clinical stage company applying synthetic biology to beneficial microbes to develop novel, living medicines, today announced the publication in Science Translational Medicine of clinical data from its Phase ...
Jan 17, 2019
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For more than 3 million people around the world, kidney failure is a life-altering diagnosis, if not a life-threatening one. While about 17 percent of people in the U.S. with end-stage kidney disease are now getting transplants, ...
Nov 5, 2018
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Horizon Pharma is buying Hyperion Therapeutics for about $1.1 billion, gaining two treatments for genetic disorders.
Mar 30, 2015
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(HealthDay)—Ravicti (glycerol phenylbutyrate) has been approved by the U.S. Food and Drug Administration to treat certain urea cycle disorders (UCDs) in people 2 years and older.
Feb 1, 2013
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