Medical research

Researchers describe building blocks of HIV's protective shell

The genome of the HIV-1 virus is protected by a conical-shaped protein shell called a capsid, which performs many functions crucial to viral infection—shielding the virus from the immune system, attaching to cell's transport ...

Medical research

Molecular switch for 'exhaustion mode' of immune cells discovered

Tumors and certain viral infections pose a challenge to the human body which the immune system typically fails to handle. In these diseases it switches to a hypofunctional state that prevents adequate protection. However, ...

Diseases, Conditions, Syndromes

How the dengue virus replicates in infected cells

The nonstructural protein 1 (NS1) of the dengue virus interacts with another viral protein called NS4A-2K-4B to enable viral replication, according to a study published May 9 in the open-access journal PLOS Pathogens by Ralf ...

Immunology

Study identifies viral peptides critical to natural HIV control

Investigators at the Ragon Institute of MGH, MIT and Harvard have used a novel approach to identify specific amino acids in the protein structure of HIV that appear critical to the ability of the virus to function and replicate. ...

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