Medical research

Revealed: Brain 'switch' tells body to burn fat after a meal

Scientists at Monash University's Biomedicine Discovery Institute have found a mechanism by which the brain coordinates feeding with energy expenditure, solving a puzzle that has previously eluded researchers and offering ...

Diabetes

Metformin combats adipose tissue expansion via AMPK

(HealthDay)—AMPK activation by metformin is associated with inhibition of interstitial fibrosis and suppression of transforming growth factor β-1 (TGF-β1), according to a study published online May 13 in Diabetes.

Medical research

Cholesterol-lowering drugs reduce brown adipose tissue

ETH Zurich scientists have shown that statins, one of the most commonly prescribed classes of pharmaceuticals, reduce beneficial brown adipose tissue. But this is no reason to demonise these drugs, the researchers insist.

Immunology

Innate immune responses to high-fat diets lead to obesity

Why is eating a high fat diet a recipe for obesity? According to a new study from the RIKEN Center for Integrative Medical Sciences (IMS) in Japan, the answer involves the activity of a specific type of immune cell that lives ...

Medical research

Mice will help reveal the roles of human brown fat

When it gets cold around you, your body turns up the heat to maintain its normal temperature. The heat is produced by brown adipose tissue, or brown fat, which also plays a role in how the body uses glucose and fat. However, ...

Diabetes

PPAR-gamma antagonist imatinib improves insulin sensitivity

(HealthDay)—Imatinib (Gleevec) blocks CDK5-mediated peroxisome proliferator-activated receptor γ (PPARγ) phosphorylation as an antagonist ligand, improving insulin sensitivity and promoting browning of white adipose tissue, ...

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