Yale pharmacology professor Barbara Ehrlich and her team have uncovered a mechanism driving a rare, lethal disease called Wolfram Syndrome and also a potential treatment. Their findings appear in the July 6 edition of Proceedings ...
Jul 16, 2020
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Using induced pluripotent stem cells produced from the skin of a patient with a rare, genetic form of insulin-dependent diabetes called Wolfram syndrome, researchers transformed the human stem cells into insulin-producing ...
Apr 22, 2020
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Cell death can trigger numerous diseases, including a rare and severe form of diabetes known as Wolfram syndrome. The cascade of cell death occurs when molecules spill from one part of a cell into another where they don't ...
Jun 23, 2015
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A commonly prescribed muscle relaxant may be an effective treatment for a rare but devastating form of diabetes, researchers at Washington University School of Medicine in St. Louis report.
Nov 24, 2014
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The rare disorder Wolfram syndrome is caused by mutations in a single gene, but its effects on the body are far reaching. The disease leads to diabetes, hearing and vision loss, nerve cell damage that causes motor difficulties, ...
Sep 17, 2012
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Inflammation and cell stress play important roles in the death of insulin-secreting cells and are major factors in diabetes. Cell stress also plays a role in Wolfram syndrome, a rare, genetic disorder that afflicts children ...
Aug 7, 2012
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(Medical Xpress) -- Children with a rare syndrome that includes a form of insulin-dependent diabetes have brain abnormalities that appear to set the stage for cognitive problems later in life, according to new research at ...
Jul 12, 2012
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Researchers at Washington University School of Medicine in St. Louis are launching a new clinical trial to assess the safety of a drug treatment for patients with the rare disease Wolfram syndrome.
Nov 11, 2016
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Although mitochondria, the tiny capsules that produce energy for the cell, are known to play some role in neurodevelopmental and psychiatric disorders, the contribution of mitochondrial dynamics (mitochondrial trafficking, ...
Jul 19, 2016
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Scientists from the New York Stem Cell Foundation (NYSCF) Research Institute and Columbia University Medical Center (CUMC) have used stem cells created from the skin of patients with a rare form of diabetes—Wolfram syndrome—to ...
Nov 13, 2013
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