Among many interventions which have been used to address this major issue, ranging from medications to lifestyle modifications, an increasingly popular dietary intervention has been intermittent fasting, where calories are consumed within a specific timeframe. Examples include the "16:8 fasting" regime, where calories are restricted for 16 hours followed by an 8-hour eating window, and longer fasts reaching over 48 hours.

Intermittent fasting has gained significant attention in recent years, and emerging evidence from various studies suggests several potential benefits and mechanisms.

A possible benefit that can be unlocked through intermittent fasting is the concept of metabolic switch, where a person switches from using sugar as their primary source of energy to using fat. When fat is broken down, the body reaches a metabolic state widely known as ketosis, where ketones are produced as an alternative energy source.

In a first-in-kind study, Professor Dean Ho, Director of the Institute for Digital Medicine (WisDM) at the Yong Loo Lin School of Medicine, National University of Singapore (NUS Medicine), documented his own journey of using digital health technologies, including sensors and wearables, and intermittent fasting to delve into the concept of ketosis and its health benefits.