Multihormone reverses metabolic damage of high calorie diet

January 15, 2014

Importantly, the scientists found out that treatment of obese mice with this GLP-1/Glucagon co-agonist improves metabolism and body weight associated with restored function of the weight lowering hormone leptin, even in the continued presence of a high-fat, high-sugar diet. The results are published in the current issue of the official journal of the American Diabetes Association Diabetes.

The adipocyte plays a key role in the physiology of energy and . Leptin is normally secreted from adipose tissue to blood in proportion to the amount of body fat. Increased inform the brain of stored calories and it responds to inhibit food intake, increase energy expenditure and decrease blood glucose. However, obese individuals are resistant to leptin's metabolic effects, which limits the use of leptin as an anti-obesity drug. In their new study, the group of Dr. Timo Müller (Institute of Diabetes and Obesity, Helmholtz Center Munich, Germany) discovered that treatment of diet-induced with a peptide that simultaneously activates GLP-1/glucagon receptors reversed leptin resistance, improved and normalized glucose metabolism even without switching to a healthier diet.

"We are particularly encouraged to see that adding leptin produced weight loss beyond the benefits of the peptide-based, co-agonist" says Prof. Matthias Tschöp, Research Director of the Helmholtz Diabetes Center and Chair of Metabolic Diseases at Technische Universität München, Germany. The identification of this novel treatment strategy is the result of many years of collaboration with Ambrx and Prof. Richard DiMarchi (Indiana University) who noted: "The results are inspiring, and establish a basis for validation in human studies". Dr. Christoffer Clemmensen, the lead author of the study, adds: "If this concept proves safe and efficient at least in specific subpopulations of obese patients, then we may have come a step closer to personalized prevention of type 2 ".

Their findings, just published in the journal Diabetes, are aligned with the overall research objective of the Helmholtz Diabetes Center at Helmholtz Zentrum Munich, partner of the German Center for Diabetes Research (DZD). We aim to establish new approaches in the diagnosis, therapy and prevention of civilization's major diseases and to develop these approaches as quickly as possible in the context of translational research in order to provide specific benefits for society.

Explore further: Voluntary exercise by animals prevents weight gain, despite high-fat diet

More information: Clemmensen C, Chabenne J, Finan B, Sullivan L, Fischer K, Küchler D, Sehrer L, Ograjsek T, Hofmann S, Schriever SS, Pfluger PT, Pinkstaff J, Tschöp MH, Dimarchi R, Müller TD. GLP-1/glucagon co-agonism restores leptin responsiveness in obese mice chronically maintained on an obesogenic diet. Diabetes. 2013 Dec 30. [Epub ahead of print]

Related Stories

Target for obesity drugs comes into focus

October 11, 2012

(Medical Xpress)—Researchers at the University of Michigan have determined how the hormone leptin, an important regulator of metabolism and body weight, interacts with a key receptor in the brain.

Doubling down against diabetes: Turbo-charged gut hormones

November 13, 2012

A collaboration between scientists in Munich, Germany and Bloomington, USA may have overcome one of the major challenges drug makers have struggled with for years: Delivering powerful nuclear hormones to specific tissues, ...

Amino acid with promising anti-diabetic effects

September 9, 2013

New experiments conducted by researchers from the University of Copenhagen show that the amino acid arginine – found in a wide variety of foods such as salmon, eggs and nuts – greatly improves the body's ability to metabolise ...

Weight loss through the use of intestinal barrier sleeves

October 10, 2013

Scientists from the Helmholtz Zentrum München in cooperation with the University of Cincinnati, USA, have discovered that the placement of a non-permeable tube in the small intestine leads to reduced nutrient absorption ...

Recommended for you

Drug prevents type 1 diabetes in mice, study finds

September 14, 2015

The buildup of a substance in the pancreas during the pre-symptomatic stage of Type 1 diabetes is essential to the development of the disease, Stanford University School of Medicine researchers have shown.

Bacteria may cause type 2 diabetes

June 1, 2015

Bacteria and viruses have an obvious role in causing infectious diseases, but microbes have also been identified as the surprising cause of other illnesses, including cervical cancer (Human papilloma virus) and stomach ulcers ...

Engineered hot fat implants reduce weight gain in mice

August 20, 2015

Scientists at the University of California, Berkeley, have developed a novel way to engineer the growth and expansion of energy-burning "good" fat, and then found that this fat helped reduce weight gain and lower blood glucose ...


Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.