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Clinical pharmacology news
Natural compound shows promise against C. difficile while largely sparing healthy gut bacteria
The pathogen Clostridioides difficile (C. difficile) is naturally present in the intestines of many people. When present in small numbers, it usually causes no symptoms. Treatment with broad-spectrum antibiotics can severely ...
14 hours ago
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Common herbal sleep aid shows signs of addictive potential
Cannabinol is a popular ingredient in over-the-counter sleep products, marketed as a gentle, plant-derived way to unwind at the end of the day. But new research conducted at the University of Connecticut suggests consumers ...
19 hours ago
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NAD-boosting treatment shows no Parkinson's benefit in yearlong trial
A major clinical trial involving 410 people with early Parkinson's disease has found no clinical benefit from nicotinamide riboside (NR), a compound that increases cellular levels of nicotinamide adenine dinucleotide (NAD). ...
13 hours ago
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Technology inspired by 3D printing could transform how medicines are tailored to patients
Technology inspired by 3D printing is already being introduced in hospitals and specialized pharmacies to produce personalized medicines tailored to individual patients. In her doctoral thesis at Åbo Akademi University, Mahsa ...
9 hours ago
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Pharmaceutical company marketing negatively influences prescribing
Doctors' prescribing habits are heavily influenced by payments, gifts and free meals from pharmaceutical companies, leading to more prescriptions for more expensive, less appropriate drugs, a new Cochrane review finds. This ...
11 hours ago
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Study shows how the toxic substances mixed into fentanyl vary across the US and change over time
Public health officials and law enforcement agents are facing a growing challenge in combating the fentanyl epidemic: They lack detailed and timely information on the harmful and potentially deadly substances, including anesthetics, ...
18 hours ago
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Hyponatremia risk may differ across second-generation antipsychotics
Antipsychotics are used to treat schizophrenia, along with bipolar disorder and major depressive disorder. However, these medications can be associated with hyponatremia, a serious reduction in blood sodium levels.
16 hours ago
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Thinking of taking melatonin to help you sleep? Here's what you need to know
Whether you're struggling with jet lag, working shifts and sleeping during the day, or dealing with more severe insomnia, you might have wondered if melatonin can help you get better sleep.
17 hours ago
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How a new long-acting HIV drug combo tackles resistance
A new long-acting HIV treatment could expand options for people who have trouble taking daily pills and whose virus is resistant to some commonly used HIV drugs, according to a new UC San Francisco study.
20 hours ago
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Q&A: How FDA decision is speeding development of new osteoporosis drugs
Osteoporosis weakens bones and makes them more likely to break. The disease affects about 10 million Americans over age 50, including one in five women. And those numbers are expected to rise as the share of Americans 65 ...
20 hours ago
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Children living with sickle cell can be treated safely using hydroxyurea, 10-year trial finds
New research shows the efficacy and safety of hydroxyurea treatment for sickle cell anemia at four low-income sites in Africa, with no increase in clinically diagnosed infections.
Oct 7, 2026
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Years of opioid use do not improve chronic back pain, study finds
Taking opioids for years does not seem to reduce pain or improve functioning in people with chronic back pain, according to a new Northwestern University study that compared 70 long-term opioid users with 70 similar patients ...
Oct 7, 2026
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Parasitic worms could hold the key to treating immune system diseases
For millions of years, parasitic worms have had to survive inside animals without being destroyed by their hosts' immune systems. To do that, they have evolved remarkably effective ways of dampening the immune response.
Oct 7, 2026
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Experimental cancer treatment disrupts cell communication to suppress tumor growth in animal tests
A research team has developed an anticancer treatment platform that simultaneously targets cancer cells and the surrounding cells that support them while blocking communication between the two.
Oct 7, 2026
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Intranasal sufentanil-ketamine appears safe, effective for pediatric acute pain
Intranasal sufentanil-ketamine is fast-acting and appears to be well tolerated and effective at curbing acute pain for pediatric patients in the emergency department, according to a study presented at the annual European ...
Oct 7, 2026
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Common epilepsy medication and birth control combinations may reduce contraceptive effectiveness
Nearly one-third of people with epilepsy who were prescribed certain hormonal contraceptives also received antiseizure medications that may make those contraceptives less effective, according to a University of Pittsburgh–led ...
Oct 7, 2026
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Two medications demonstrated comparable results in treating compulsive sexual behavior disorder
Naltrexone and fluoxetine demonstrated similar results in the treatment of people with compulsive sexual behavior disorder in a new study from Karolinska Institutet. Published in BMJ Mental Health, the study found no clear ...
Oct 7, 2026
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Starting Alzheimer's treatment earlier increases benefits to patients and society
New treatments that can slow the progression of Alzheimer's disease could provide significant lifetime benefits to patients and society, with even greater benefits when initiated earlier, according to new research from the ...
Oct 7, 2026
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Blocking a nerve protein could interrupt chronic pain rather than simply mask it
Chronic pain can continue long after an initial injury. When a nerve outside the brain and spinal cord (a peripheral nerve) is damaged and does not heal properly, it keeps sending constant pain signals. Over time, this nonstop ...
Oct 6, 2026
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Cancer trial drug may work differently than scientists believed, raising concerns for clinical research
A cancer drug currently being tested in patients may have entered clinical trials based on an incorrect understanding of how it works, according to a new study led by the University of Sydney in collaboration with Goethe ...
Oct 6, 2026
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Antifungal use during pregnancy shows link to altered hormone levels in babies
Many pregnant women develop fungal infections, which are often treated with widely used azole-based antifungal medicines. A new study involving researchers from the DTU National Food Institute and Copenhagen University Hospital ...
Oct 6, 2026
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Promising nonopioid approach for reducing neuropathic pain disrupts a protein interaction
Understanding and treating chronic neuropathic pain has remained challenging due to its complex nature. New research from the lab of Clifford Woolf, MB, BCh, Ph.D., at Boston Children's Hospital's FM Kirby Neurobiology Center ...
Oct 6, 2026
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Antimalarial drug persists in mosquitoes for days, potentially exposing developing parasites
Antimalarial drugs are designed to protect people from malaria, but they may also affect the mosquitoes exposed to them during blood meals. A new Yale study, published in The Journal of Infectious Diseases, investigates the ...
Oct 6, 2026
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1 in 3 with lupus takes supplements, medications with potential for interactions
Nearly 1 in 3 patients with systemic lupus erythematosus (SLE) are taking a supplement-medication combination with potential for an interaction, according to a study published online Sept. 22 in Arthritis Care & Research.
Oct 6, 2026
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Why antidepressants can stop working after initially helping
Antidepressant use continues to rise. In England, 96 million antidepressant prescription items were dispensed to an estimated 9.1 million patients in 2025–2026. These medicines are prescribed for depression and other conditions, ...
Oct 6, 2026
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