Cardiology

Women less likely to receive treatment for myocardial infarction

(HealthDay)—Use of sex-specific diagnostic thresholds for myocardial infarction identifies more additional women than men with myocardial injury, but women are less likely to receive treatment, according to a study published ...

Cardiology

Less inflammation = better healing

Myocardial infarction (MI), commonly called heart attack, remains a leading cause of mortality and morbidity worldwide, raising an urgent need for novel therapies.

Cardiology

Heart attack modeled with human stem cells

Researchers at Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences developed a model of myocardial infarction using cardiomyocytes differentiated from human induced pluripotent stem cells.

Cardiology

Risk for ischemic CV events lower with colchicine after MI

(HealthDay)—Patients with recent myocardial infarction have a lower risk for ischemic cardiovascular events with colchicine versus placebo, according to a study published online Nov. 16 in the New England Journal of Medicine ...

Cardiology

Model predicts six-month post-AMI mortality for older adults

(HealthDay)—A newly developed model has good discriminatory ability for six-month post-acute myocardial infarction (AMI) mortality, according to a study published online Dec. 10 in the Annals of Internal Medicine.

Cardiology

Vigorous activity weekly may improve outcomes in stable CAD

Performing vigorous physical activity once or twice a week compared with sedentary behavior or light physical activity may improve long-term cardiac health in patients with stable coronary artery disease, according to a study ...

Medications

Impact of valsartan recall examined for Ontario, Canada

(HealthDay)—The generic valsartan recall has had population-level impacts on patients in Ontario, Canada, according to a research letter published online Nov. 11 in Circulation to coincide with the annual meeting of the ...

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Myocardial infarction (MI) or acute myocardial infarction (AMI), commonly known as a heart attack, results from the interruption of blood supply to a part of the heart, causing heart cells to die. This is most commonly due to occlusion (blockage) of a coronary artery following the rupture of a vulnerable atherosclerotic plaque, which is an unstable collection of lipids (cholesterol and fatty acids) and white blood cells (especially macrophages) in the wall of an artery. The resulting ischemia (restriction in blood supply) and ensuing oxygen shortage, if left untreated for a sufficient period of time, can cause damage or death (infarction) of heart muscle tissue (myocardium).

Classical symptoms of acute myocardial infarction include sudden chest pain (typically radiating to the left arm or left side of the neck), shortness of breath, nausea, vomiting, palpitations, sweating, and anxiety (often described as a sense of impending doom). Women may experience fewer typical symptoms than men, most commonly shortness of breath, weakness, a feeling of indigestion, and fatigue. Approximately one-quarter of all myocardial infarctions are "silent", that is without chest pain or other symptoms.

Among the diagnostic tests available to detect heart muscle damage are an electrocardiogram (ECG), echocardiography, cardiac MRI and various blood tests. The most often used blood markers are the creatine kinase-MB (CK-MB) fraction and the troponin levels. Immediate treatment for suspected acute myocardial infarction includes oxygen, aspirin, and sublingual nitroglycerin.

Most cases of STEMI (ST elevation MI) are treated with thrombolysis or percutaneous coronary intervention (PCI). NSTEMI (non-ST elevation MI) should be managed with medication, although PCI is often performed during hospital admission. In people who have multiple blockages and who are relatively stable, or in a few emergency cases, bypass surgery may be an option, especially in diabetics.

Heart attacks are the leading cause of death for both men and women worldwide. Important risk factors are previous cardiovascular disease, older age, tobacco smoking, high blood levels of certain lipids (triglycerides, low-density lipoprotein) and low levels of high density lipoprotein (HDL), diabetes, high blood pressure, obesity, chronic kidney disease, heart failure, excessive alcohol consumption, the abuse of certain drugs (such as cocaine and methamphetamine), and chronic high stress levels.

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