A new study has shown that a commonly used vector for large gene transfer can successfully deliver genes to retinal cells in the laboratory, but when injected subretinally into rats it provokes a robust and acute inflammatory ...
Nov 12, 2019
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Gene therapy—there is a long road ahead to mainstream techniques and ensure that the technology is cost-effective.
Nov 12, 2019
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Scientists are increasingly tracing a variety of diseases back to the so-called epigenome, a type of indexing system imposed on DNA that dictates how genes should be read by the cells. Now, a new study finds that changes ...
Nov 12, 2019
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Recent studies have found a high genetic similarity of the psychiatric diseases schizophrenia and bipolar disorder, whose disease-specific changes in brain cells show an overlap of more than 70 percent. These changes affect ...
Nov 12, 2019
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Those with a family history of schizophrenia and men with lower IQ are more likely to struggle with treatment-resistant schizophrenia than others with the mental disorder, according to a study by researchers at Karolinska ...
Nov 12, 2019
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Using CRISPR/Cas9 knockout screens a multi-institutional research team systematically interrogated the essentiality of more than 10,000 forkhead box protein A1 (FOXA1) and CTCF binding sites in breast and prostate cancer ...
Nov 11, 2019
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Mitochondrial donation is an assisted reproductive technology sometimes described as "three-parent IVF". It's designed for women at high risk of passing on faulty mitochondrial DNA and having a child with severe mitochondrial ...
Nov 11, 2019
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MIPT researchers have collaborated with Atlas Biomedical Holding and developed a new bioinformatics data analysis method. The developed program, EphaGen, can be used for quality control when diagnosing genetic diseases. The ...
Nov 08, 2019
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The constant battle against infectious pathogens has had a decisive influence on the human immune system over the course of our evolution. A key role in our adaptation to pathogens is played by HLA molecules. These proteins ...
Nov 08, 2019
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Scientists at the University of Virginia School of Medicine have developed a better way to determine what our genes do, allowing scientists to better probe the genetic causes of diseases and more efficiently determine whether ...
Nov 08, 2019
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Researchers at Penn State College of Medicine have developed a new method to model how genes interact with each other—and it may someday contribute to the development of personalized treatments for patients.
Nov 07, 2019
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Whole-genome sequencing can be used to diagnose intellectual disability more accurately than other methods of genetic analysis, researchers at Karolinska Institutet report in the scientific journal Genome Medicine. Whole-genome ...
Nov 07, 2019
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For the first time, the UNC School of Medicine lab of Jonathan Schisler, MS, Ph.D., linked the specific biochemical changes to a protein called CHIP to specific disease characteristics of patients with a wide range of rare ...
Nov 06, 2019
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Researchers Lorenzo Pasquali and Mireia Ramos-Rodríguez have published recently in Nature Genetics the results of a study on the mechanisms that cause an inflammatory response to trigger pancreatic beta-cell death, leading ...
Nov 06, 2019
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The first attempt in the United States to use a gene editing tool called CRISPR against cancer seems safe in the three patients who have had it so far, but it's too soon to know if it will improve survival, doctors reported ...
Nov 06, 2019
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Hard-to-study mutations in the human genome, called short tandem repeats, known as STRs or microsatellites, are implicated in the expression of genes associated with complex traits including schizophrenia, inflammatory bowel ...
Nov 06, 2019
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(HealthDay)—For patients with obesity, undergoing bariatric surgery is associated with a significantly reduced risk for cancer overall and a lower rate of breast malignancy among those with a genetic predisposition to breast ...
Nov 05, 2019
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The process of in vitro fertilization (IVF) is often unsuccessful due to chromosomal changes that occur in an embryo fertilized in a test tube. So far, it was not known whether these changes also transfer to the baby, but ...
Nov 05, 2019
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