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Genetics news
Genetics
Key genetic mechanism provides insights into facial development and congenital issues
An international team of researchers has identified a key genetic mechanism that regulates the formation and migration of cranial neural crest cells, which are essential for developing facial structures.
5 hours ago
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Genetics
Mini-brains reveal how mitochondrial mutations affect brain cells
Researchers at the University of Bergen have used advanced stem cell technology to develop mini-brains, also called brain organoids, that can mimic disease processes caused by mitochondrial failure. This could open new avenues ...
6 hours ago
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How DNA shapes reproductive health, fertility and even life expectancy
Led by researchers from the University of Oxford's Leverhulme Center for Demographic Science and the University of Iceland, a review, published in Nature Aging, explores how genetic variations can explain differences in reproductive ...
7 hours ago
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How cells repair DNA's protective barrier: Addressing a rare genetic disorder characterized by rapid aging in children
Researchers at Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, have discovered how a protein called lamin A helps repair the protective barrier around a cell's DNA. The findings reveal lamin A's unique role ...
4 hours ago
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High-altitude gene variant linked to better blood cancer prognosis
Two researchers from Huntsman Cancer Institute at the University of Utah (the U) have discovered a gene variant found in high-altitude Andean populations that they believe could be a new biomarker for predicting the severity ...
8 hours ago
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Genetic toolkit uses mouse models to modify and investigate gene function
A team at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) has developed a comprehensive set of innovative genetic tools and mouse lines, called iFlpMosaics, designed to enhance the study of gene function and ...
13 hours ago
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Lentiviral vectors offer gene therapy option for hemophilia A patients with anti-AAV antibodies
Research led by Christian Medical College in Vellore, India, has demonstrated the successful use of lentiviral vectors to deliver gene therapy for patients with severe hemophilia A. The study presents a potential alternative ...
Immune system 'tuning dial' sheds light on why COVID makes some sicker than others
Why does the COVID-19 virus make some people sicker than others? For years, scientists have looked to a critical piece of immune system machinery—known as the interferon pathway—for answers. There, when our cells sense ...
Dec 12, 2024
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RNA:DNA 'sandwich' plays key role in behavioral adaptations arising from emotional experiences, research reveals
A team of neuroscience researchers at the Medical University of South Carolina reports in Science the discovery of a new genetic regulatory mechanism involved in behavioral adaptations to emotional experiences in a preclinical ...
Dec 12, 2024
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23andMe's struggles are a sign that direct-to-consumer DNA testing needs stronger oversight
23andMe, a major company providing direct-to-consumer genetic testing, has been struggling financially since late 2023. In September 2024, the company's stock hit a rock-bottom of US$0.30, down 96 percent from its peak share ...
Dec 12, 2024
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New drug strategy targets rare immune disorders' genetic roots
Several rare immune disorders are caused by mutations in the patient's DNA. In a new study published in the Journal of Clinical Immunology, the University of Surrey and its collaborators found that targeting the mutated pathways ...
Dec 12, 2024
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Protein discovery illuminates how the immune system switches between rest and action
Cells in the immune system don't always fight; they often rest and wait for threats, like viruses or bacteria. When such threats emerge, the cells activate to defend the body. This delicate balance between rest and activation ...
Dec 11, 2024
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You are what you eat…and so are your grandkids? Study links poor diet to multi-generational health issues
You are what you eat, as the adage goes. But a new study from Tulane University found that what's missing from your diet may also impact the health of your descendants across multiple generations.
Dec 11, 2024
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RNA fragment is key regulator of gene expression and potential therapeutic target in cancer, study reveals
A novel study from Korea uncovers the process of synthesis and pivotal role of the transfer RNA-derived fragment, 5′-tRH-GlyGCC, in cancer progression. By interacting with splicing factors, it regulates gene expression, ...
Dec 11, 2024
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DNA sequencing test can predict prognosis for advanced prostate cancer patients
Published in Nature Communications, a new study led by the University of Minnesota Medical School and Duke University found that a DNA sequencing test for advanced prostate cancer patients can distinguish between patients ...
Dec 11, 2024
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Researchers unlock new gene therapy targets for diabetic kidney disease
New potential therapeutic targets have been identified for diabetic kidney disease (DKD)—the leading cause of kidney failure in the world—that could see patients treated with new gene and drug therapies preventing the ...
Dec 10, 2024
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Scientists construct human genome microsatellite polymorphism map
A research team has recently constructed a global polymorphism genetic map of variable number tandem repeats (VNTRs), termed the NyuWa VNTR Polymorphism Map.
Dec 10, 2024
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Study links smoking to genetic mutations in blood cancer
Smokers with myelodysplastic syndromes (MDS) or a precursor condition had elevated levels of genetic mutations linked to the disease, a new study shows. The study also found that heavier smokers accumulated more mutations, ...
Dec 10, 2024
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Gene variant linked to reduced thiopurine metabolism in African ancestry
Mayo Clinic researchers found that a gene variant, the TPMT∗8 allele, is associated with reduced metabolism of the thiopurine class of drugs. TPMT∗8 is relatively common in individuals of African or African American descent.
Dec 10, 2024
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Scientists identify a probable contributor to weakness of the aorta in people with genetic disorder
Studying the cells of people and genetically engineered mice, Johns Hopkins Medicine scientists say they have uncovered a potential reason why patients with Loeys-Dietz syndrome, an inherited connective tissue disorder, are ...
Dec 9, 2024
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Genetic code discovery could redefine understanding of cancer origins
A group of scientists at VCU Massey Comprehensive Cancer Center has revealed a new genetic code that acts like a cancer ringleader, recruiting and deploying a gang of tumor cells to incite a biological turf war by invading ...
Dec 9, 2024
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Researchers discover a genetic disposition increasing the risk of breast cancer metastasis
Ninety percent of cancer deaths are due to the spread of cancer, not complications from the original tumor. Thus, for over 50 years now, scientists have been on a quest to identify which malignant mutations within the tumor ...
Dec 9, 2024
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Targeting novel molecular mechanisms may repair damaged DNA in cancer cells
Northwestern Medicine investigators have discovered new molecular mechanisms underlying DNA repair dysregulation in prostate cancer cells, findings that may inform the development of new targeted therapies for patients that ...
Dec 9, 2024
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Universal genetic testing of breast cancer patients could improve treatment plans
A new study demonstrates how universal genetic testing for breast cancer can ensure no patient is missed for advanced therapies.
Dec 9, 2024
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Brain tissue study offers new genetic insights into Alzheimer's disease complexity
A study by the team of Prof. Kristel Sleegers (VIB-UAntwerp), published in Acta Neuropathologica, has offered new insights into the genetic factors that drive Alzheimer's disease. Using samples from the Leuven Brain Collection, ...
Dec 9, 2024
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