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Genetics
A key DNA repair gene known as X-ray repair cross-complementing group 1, or XRCC1, plays a vital role in maintaining genomic stability and is highly expressed in the early stages of sperm cell development (also known as spermatogenesis). ...
Apr 18, 2019
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Genetics
Gene therapy offers the promise of a cure for beta-thalassemia and a new study has shown that it is associated with fewer complications and hospital admissions over 2 years than treatment by allogeneic hematopoietic stem ...
Apr 18, 2019
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Around four million people in the UK carry genetic variants that protect them from obesity, type 2 diabetes and heart disease, suggests new research from the University of Cambridge. The team say the discovery could lead ...
Apr 18, 2019
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Researchers have discovered a key clue into the development of the pancreas and brain by studying rare patients born without a pancreas. The study from the Wellcome Sanger Institute, the University of Exeter and collaborators ...
Apr 18, 2019
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Researchers have come up with a scoring system based on genetic markers that predicts an individual's inborn risk for obesity. Using data from the largest existing genome-wide study of obesity, they applied new algorithms ...
Apr 18, 2019
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Scientists at Christiana Care Health System's Gene Editing Institute and NovellusDx, an Israeli biotechnology company, have deployed a breakthrough CRISPR gene-editing tool to successfully engineer multiple edits simultaneously ...
Apr 18, 2019
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A team of researchers at the Albert Einstein College of Medicine has found that the number of somatic mutations in human B lymphocytes increases with age. In their paper published in Proceedings of the National Academy of ...
Using CRISPR gene editing, a team from Children's Hospital of Philadelphia (CHOP) and Penn Medicine have thwarted a lethal lung disease in an animal model in which a harmful mutation causes death within hours after birth. ...
Apr 17, 2019
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Stanford University has cleared three faculty members of any wrongdoing in dealings with a Chinese scientist who claims to have helped make the world's first gene-edited babies.
Apr 17, 2019
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Cancer cells are characterised by the ability to evade apoptosis, a type of programmed cell death that allows the organism to remove damaged cells. Many studies devoted to new chemotherapy treatments aim to induce apoptosis ...
Apr 17, 2019
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Cystic fibrosis is a devastating disease caused by mutations in a specific gene, known as the CFTR gene. But not everyone with cystic fibrosis has the same symptoms or responds to drug treatments in the same way. In a new ...
Apr 17, 2019
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Human genomes vary quite a bit from individual to individual. These differences include single nucleotide changes, or "spelling mistakes" in the DNA sequence, but even more variation comes from structural variants, which ...
Apr 16, 2019
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An initial gene analysis may yield better outcomes when patients are treated with the antipsychotic drugs risperidone and aripiprazole. A novel study shows how the activity of a specific enzyme, which metabolises the two ...
Apr 16, 2019
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Oral cancer is known for its high mortality rate in developing countries, but an international team of scientists hope its latest discovery will change that.
Apr 16, 2019
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Researchers have discovered that the spatial organization of the genome can be altered using small molecule compounds which are considered as promising anti-cancer drugs. This work opens up the prospect of developing a new ...
Apr 16, 2019
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A new study from BC Children's Hospital, the University of British Columbia (UBC) and an international team of researchers published in the New England Journal of Medicine is the first to identify a rarely-seen type of DNA ...
Apr 15, 2019
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Medications known as PARP inhibitors have emerged as a promising therapy for several forms of cancer fueled by a defect in the cells' DNA repair machinery. Yet many people with cancers caused by the defect, known as HR deficiency, ...
Apr 15, 2019
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Two images published in a Cell Stem Cell paper in September 2018 summarize years of relentless questioning on how skin stem cells regenerate, which has driven much of the research of Valentina Greco, Ph.D., Carolyn Walch ...
Apr 15, 2019
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Could a medication someday help the brain heal itself after a stroke, or even prevent damage following a blow to the head? A new USC study lends support to the idea.
Apr 15, 2019
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Maintaining a healthy body weight is no simple matter. A better understanding of how the body regulates appetite could help tip the scale toward the healthy side. Contributing toward this goal, a team led by researchers at ...
Apr 12, 2019
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