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Genetics news
Genetics
Beyond mere blueprints: Variable gene expression patterns and type 1 diabetes
Type 1 diabetes is a disorder in which the immune system inappropriately targets a class of cells in the pancreas known as β cells that produce the hormone insulin, which plays an important role in regulating bloodstream ...
Jun 18, 2021
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Oncology & Cancer
Most cancer cells grown in a dish have little in common with cancer cells in people
In a bid to find or refine laboratory research models for cancer that better compare with what happens in living people, Johns Hopkins Medicine scientists report they have developed a new computer-based technique showing ...
Jun 17, 2021
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Slowed cell division causes microcephaly
The birth of a human being requires billions of cell divisions to go from a fertilized egg to a baby. At each of these divisions, the genetic material of the mother cell duplicates itself to be equally distributed between ...
Jun 17, 2021
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Researchers identify new gene that may increase risk of ALS
Researchers have identified a new gene that may increase a person's risk of developing ALS (Amyotrophic Lateral Sclerosis), according to a new study published in the June 16, 2021, online issue of Neurology, the medical journal ...
Jun 16, 2021
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Mitophagy reporter mouse cues future therapies, rehabilitation strategies
The loss of muscle tissue—referred to as muscle atrophy in medical terms—can occur as a result of lack of physical activity for an extended period of time; aging; alcohol-associated myopathy—a pain and weakness in muscles ...
Jun 15, 2021
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New gene therapy uses Tylenol to combat genetic diseases
Researchers have developed a new approach to gene therapy that leans on the common pain reliever acetaminophen to force a variety of genetic diseases into remission.
Jun 14, 2021
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A 'pump' gene's surprising role in early brain formation
In polymicrogyria, the cortex of the brain has many irregular, small folds (gyria) and disorganization of its layers. Many affected children have severe developmental delay, intellectual disabilities, and epilepsy, and many ...
Jun 14, 2021
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High genetic running capacity promotes efficient metabolism with aging
High running capacity is associated with health and longevity. However, whether high genetic running capacity promotes more efficient metabolism with aging is not known. A new study conducted in collaboration between the ...
Jun 14, 2021
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Reference genome comparison finds exome variant discrepancies in 206 genes
In the two decades since the Human Genome Project mapped the entire human genome, improvements in technology have helped in developing updated reference genomes used for sequencing. But while the GRCh38 (hg38) human reference ...
Jun 14, 2021
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The use and misuse of race in health care
COVID-19 has put race-based health disparities on full display, but such inequities extend far deeper than the current pandemic. An enduring challenge for physicians and scientific researchers has been to distinguish health ...
Jun 11, 2021
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Prostate cancer and a possible link with schizophrenia
Oncotarget published "The presence of polymorphisms in genes controlling neurotransmitter metabolism and disease prognosis in patients with prostate cancer: a possible link with schizophrenia" reported that polymorphisms ...
Jun 11, 2021
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Trapping DNA damage: Untangling the proteins that trigger some cancerous tumors
Even on a good day, DNA is constantly getting damaged.
Jun 10, 2021
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A new technique for correcting disease-causing mutations
Gene editing, or purposefully changing a gene's DNA sequence, is a powerful tool for studying how mutations cause disease, and for making changes in an individual's DNA for therapeutic purposes. A novel method of gene editing ...
Jun 10, 2021
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Nearly 1 in 5 patients who die from unexplained sudden cardiac death have suspicious gene
As many as 450,000 Americans die every year from a sudden, fatal heart condition, and in slightly more than one in ten cases the cause remains unexplained even after an autopsy. Researchers from the University of Maryland ...
Jun 10, 2021
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Association recommends minimum set of pharmacogenetic alleles to guide clinical CYP2D6 genotype testing
The Association for Molecular Pathology (AMP), the premier global, molecular diagnostic professional society, has today published consensus recommendations to aid in the design and validation of clinical CYP2D6 assays, promote ...
Jun 10, 2021
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LIM domain only 1: One gene, many roles in cancer
Humans have long been plagued by a myriad of deadly cancers. Parallelly, they attempted different permutations and combinations of treatments to cure the disease. Attempts involving biomolecular targets have come to the fore ...
Jun 10, 2021
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DNA methylation changes in neurons of bipolar disorder patients
A research collaboration based in Kumamoto University, Japan, has revealed the DNA methylation status of gene transcriptional regulatory regions in the frontal lobes of patients with bipolar disorder (BD). The regions with ...
Jun 09, 2021
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Cough can run in family
A family history of cough increases the risk of both the onset and persistence of cough, according to the Ph.D. study of Anne Lätti. One in two recent-onset coughers still reported the presence of a cough 12 months later. ...
Jun 09, 2021
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Discovery of circadian rhythm gene in mice could lead to breakthroughs
That internal nagging feeling that drives you to seek sleep at night and wake in the morning to eat, work, and play, is, it turns out, genetic, and it's not just in people. Nearly every living organism—from animals to plants ...
Jun 08, 2021
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Researchers identify gene linked to congenital heart disease
New insight on the link between a gene called SORBS2 and congenital heart disease has been published today in eLife, with findings that may help explain the cause of the disease in some patients.
Jun 08, 2021
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