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Genetics news
Genetics
Personalized therapy for rare genetic diseases: Patient-derived organoids offer new hope
Children's Mercy Kansas City has achieved a significant advancement toward the treatment of rare genetic diseases through the use of personalized antisense oligonucleotides (ASOs). This innovative approach has shown promising ...
14 hours ago
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Genetics
Long read sequencing reveals more genetic information while cutting time and cost of rare disease diagnoses
One in every 10 people worldwide is impacted by a rare genetic disease but about 50% of them remain undiagnosed despite rapid increases in genetic technology and testing. Even when a person does have access to testing, the ...
14 hours ago
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Study reveals novel insights into the molecular pathology of esophageal squamous cell carcinoma
Esophageal squamous cell carcinoma (ESCC) is a highly aggressive malignancy with poor prognosis, and understanding the molecular mechanisms underlying its progression is crucial for developing effective therapies.
14 hours ago
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Eight psychiatric disorders share the same genetic causes, study says
Psychiatric disorders often overlap and can make diagnosis difficult. Depression and anxiety, for example, can coexist and share symptoms. Schizophrenia and anorexia nervosa. Autism and attention deficit/hyperactivity disorder, ...
Jan 23, 2025
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Uncovering the role of Y chromosome genes in male fertility in mice
Researchers at the Crick have uncovered which genes on the Y chromosome regulate the development of sperm and impact fertility in male mice. This research could help us understand why some men don't produce enough sperm and ...
Jan 23, 2025
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Unlocking new insights into hereditary ovarian cancer risk
Researchers at Peter Mac have uncovered potential new heredity genes that might be responsible for causing one of the most prevalent and deadliest forms of ovarian cancer. Their work is published in the journal npj Genomic ...
Jan 23, 2025
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Transcription factor binding sites may help explain underlying causes of many diseases
A multi-institutional team of investigators have developed a catalog of transcription factor binding sites that regulate gene expression across the genome, according to a recent study published in Genome Research.
Jan 23, 2025
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Editing embryos to prevent genetic diseases: Study sparks ethical debate
Scientists from a collaboration of Australian research institutions have proposed that editing multiple genetic variants in human embryos could significantly lower the likelihood of developing complex diseases such as coronary ...
Complete recombination map of the human genome created
Scientists at deCODE genetics/Amgen have constructed a complete map of how human DNA is mixed as it is passed down during reproduction. The map marks a major step in the understanding of genetic diversity and its impact on ...
Jan 22, 2025
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Largest study on the genetics of bipolar disorder to date gives new insights into the underlying biology
Bipolar disorder is a complex psychiatric disorder, characterized by fluctuations between episodes of (hypo)mania and depression. It is estimated to affect around 40 to 50 million people worldwide. The disorder has been linked ...
Jan 22, 2025
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Mom's X chromosome could speed up brain aging, study suggests
Women are born with two X chromosomes and inherit one from each parent. But in every cell of their body, just one X chromosome is needed—so the other is randomly inactivated. Some cells use only a maternal X chromosome; ...
Jan 22, 2025
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Biomarker algorithm for Barrett's esophagus and esophageal cancer developed
By studying biomarkers known to be involved in gastrointestinal cancers, researchers at the Johns Hopkins Kimmel Cancer Center and the Johns Hopkins University School of Medicine have developed a biomarker algorithm that, ...
Jan 22, 2025
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Why our biological clock ticks: Research reconciles major theories of aging
Researchers at University of California San Diego School of Medicine have published results that shed new light on an old question: what causes aging at the molecular level? Their findings, published in Nature Aging, describe ...
Jan 21, 2025
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Study suggests stalled amyloid protein production drives Alzheimer's disease
Alzheimer's disease is likely caused by stalled protein processing in the brain, according to a new study.
Jan 21, 2025
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Gene expression analyses reveal molecular insights into bone remodeling
Bones are the living tissue on which the human skeleton is constructed and play a key role in enabling physical movements. The structural integrity of bones has been attributed to bone remodeling—a highly regulated process ...
Jan 21, 2025
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What's behind preterm birth? Scientists discover a molecular timer
A typical human pregnancy lasts 40 weeks, but most parents know this number is only a rough estimate. Babies are born on a seemingly unpredictable timeline, with a normal pregnancy ranging from 38 to 42 weeks. And 10% of ...
Jan 21, 2025
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Smartwatches reveal insights into psychiatric illnesses and genetic links
Smartwatches that can collect physical and physiological data on users could be potentially interesting tools in biomedicine to gain a better understanding of brain diseases and behavioral disorders and possible driver mutations ...
Jan 20, 2025
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Researcher discovers missing regulator in Parkinson's disease
Yulan Xiong, associate professor of neuroscience at UConn Health, and her team have discovered one more piece of the puzzle of the genetic causes of Parkinson's Disease, paving the way for new treatment options.
Jan 20, 2025
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How childhood trauma impacts our brains, bodies, and even our genes
In 1966, Romanian dictator Nicolae Ceaușescu introduced extreme policies to increase the country's birth rate. This led to the widespread abandonment of children, who ended up in orphanages in appalling conditions where ...
Jan 20, 2025
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Genetic reanalysis results in more than 500 patients receiving diagnosis
The European consortium for Solving the Unsolved Rare Diseases has demonstrated the significance of international collaboration to address the unmet medical needs for rare diseases' diagnosis. More than 500 European patients ...
Jan 17, 2025
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Interdisciplinary research lays groundwork for predicting if bone cancer will spread
Bone pain. Joint pain. Bone swelling. These are symptoms that about 1,000 people in the United States begin to feel each year shortly before being diagnosed with osteosarcoma, a type of cancer that starts in the bones. Although ...
Jan 17, 2025
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Study explores link between people's professions and their genetic predisposition to neuropsychiatric traits
Polygenic scores (PGS) are metrics used to estimate the genetic predisposition of people to developing specific mental health conditions, personality traits or diseases. In recent years, these metrics have often been used ...
Decoding HIV's tactics: RNA structures provide new insights into how virus hijacks cells
A team of scientists at the Helmholtz Institute for RNA-based Infection Research (HIRI) in Würzburg and the University of Regensburg has unveiled insights into how HIV-1, the virus responsible for AIDS, skillfully hijacks ...
Jan 16, 2025
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Surprising way that genetic mutation causes Huntington's disease changes understanding of the disorder
Scientists at the Broad Institute of MIT and Harvard, Harvard Medical School, and McLean Hospital have discovered a surprising mechanism by which the inherited genetic mutation known to cause Huntington's disease leads to ...
Jan 16, 2025
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Tagging gene-regulating DNA sequences with barcodes provides insights into human genome
An international team of researchers has taken an important step toward understanding how gene expression is controlled across the human genome. The research is published in the journal Nature.
Jan 16, 2025
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