Immunology

Ketogenic diet helps tame flu virus

A high-fat, low-carbohydrate diet like the Keto regimen has its fans, but influenza apparently isn't one of them.

Diseases, Conditions, Syndromes

Researchers study immune response to influenza

It is estimated that influenza (flu) results in 31.4 million outpatient visits each year. New research from the University of Minnesota Medical School provides insights into how the body can protect itself from immunopathology ...

Medical research

Flu antibody protects against numerous and wide-ranging strains

Researchers have found an antibody that protects mice against a wide range of lethal influenza viruses, according to a study from Washington University School of Medicine in St. Louis, Icahn School of Medicine at Mount Sinai ...

Diseases, Conditions, Syndromes

Flu shots benefit patients hospitalized with pneumonia

Routine, in-hospital influenza vaccinations for all adults hospitalized with pneumonia may save lives and reduce hospitalizations, according to a study presented at CHEST 2019, the annual meeting of the American College of ...

Diseases, Conditions, Syndromes

Do I have the flu or not?

A person has all the signs of flu: fever, chills, cough, headache and fatigue. But just because the signs are there, it's not a foregone conclusion that flu is the cause as there are other viruses and illnesses with shared ...

Vaccination

AHA: About one in three with ASCVD not receiving flu shot

About one in three individuals with atherosclerotic cardiovascular disease (ASCVD) did not receive an influenza vaccination in the past year, according to a study presented at the annual meeting of the American Heart Association, ...

Cardiology

Flu shot may aid heart bypass recovery

Getting a flu shot before heart bypass surgery can head off inflammation throughout the body and possibly lead to a healthier recovery, a new study suggests.

Diseases, Conditions, Syndromes

Infectious diseases A to Z: New flu antiviral available

For those who become ill with the flu, a new antiviral medication may help. "This is really kind of a blockbuster," says Dr. Gregory Poland, director of the Mayo Clinic Vaccine Research Group. "We have not had a new influenza ...

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Influenza, commonly referred to as the flu, is an infectious disease caused by RNA viruses of the family Orthomyxoviridae (the influenza viruses), that affects birds and mammals. The most common symptoms of the disease are chills, fever, sore throat, muscle pains, severe headache, coughing, weakness/fatigue and general discomfort. Although it is often confused with other influenza-like illnesses, especially the common cold, influenza is a more severe disease than the common cold and is caused by a different type of virus. Influenza may produce nausea and vomiting, particularly in children, but these symptoms are more common in the unrelated gastroenteritis, which is sometimes, inaccurately, referred to as "stomach flu." Flu can occasionally cause either direct viral pneumonia or secondary bacterial pneumonia.

Typically, influenza is transmitted through the air by coughs or sneezes, creating aerosols containing the virus. Influenza can also be transmitted by direct contact with bird droppings or nasal secretions, or through contact with contaminated surfaces. Airborne aerosols have been thought to cause most infections, although which means of transmission is most important is not absolutely clear. Influenza viruses can be inactivated by sunlight, disinfectants and detergents. As the virus can be inactivated by soap, frequent hand washing reduces the risk of infection.

Influenza spreads around the world in seasonal epidemics, resulting in the deaths of between &10000000000250000000000250,000 and &10000000000500000000000500,000 people every year, up to millions in some pandemic years. On average 41,400 people died each year in the United States between 1979 and 2001 from influenza. In 2010 the Centers for Disease Control and Prevention (CDC) in the United States changed the way it reports the 30 year estimates for deaths. Now they are reported as a range from a low of about 3,300 deaths to a high of 49,000 per year.

Three influenza pandemics occurred in the 20th century and killed tens of millions of people, with each of these pandemics being caused by the appearance of a new strain of the virus in humans. Often, these new strains appear when an existing flu virus spreads to humans from other animal species, or when an existing human strain picks up new genes from a virus that usually infects birds or pigs. An avian strain named H5N1 raised the concern of a new influenza pandemic, after it emerged in Asia in the 1990s, but it has not evolved to a form that spreads easily between people. In April 2009 a novel flu strain evolved that combined genes from human, pig, and bird flu, initially dubbed "swine flu" and also known as influenza A/H1N1, emerged in Mexico, the United States, and several other nations. The World Health Organization officially declared the outbreak to be a pandemic on June 11, 2009 (see 2009 flu pandemic). The WHO's declaration of a pandemic level 6 was an indication of spread, not severity, the strain actually having a lower mortality rate than common flu outbreaks.

Vaccinations against influenza are usually made available to people in developed countries. Farmed poultry is often vaccinated to avoid decimation of the flocks. The most common human vaccine is the trivalent influenza vaccine (TIV) that contains purified and inactivated antigens against three viral strains. Typically, this vaccine includes material from two influenza A virus subtypes and one influenza B virus strain. The TIV carries no risk of transmitting the disease, and it has very low reactivity. A vaccine formulated for one year may be ineffective in the following year, since the influenza virus evolves rapidly, and new strains quickly replace the older ones. Antiviral drugs such as the neuraminidase inhibitor oseltamivir can be used to treat influenza, however the effectiveness is difficult to determine due to much of the data remaining unpublished.

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