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A single protein that helps drive responses to touch, temperature, pain and itch could offer a new drug target
A light brush, a hot surface and an irritating itch all activate different sensory pathways, yet researchers have determined that, in mice, these otherwise distinct responses share a molecular helper. A team led by Bailong ...
13 hours ago
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Cholesterol transport protein emerges as possible target for Parkinson's treatment
Parkinson's disease (PD) is a neurodegenerative condition that causes the progressive loss of dopamine-producing neurons in a brain region called the substantia nigra. Its characteristic symptoms include tremors, slowed movements, ...
23 hours ago
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Medical research news
Gut immune cells sustain pain even without inflammation through newly identified signaling pathway
People with inflammatory bowel conditions such as ulcerative colitis often suffer from severe, long-lasting gut pain that lingers even after signs of inflammation are gone. Such abdominal pain can significantly affect one's ...
In parallel mouse studies, researchers fail to replicate many reported effects of psilocybin
Experimental trials of psychedelic drugs in both humans and animals have produced conflicting results, creating doubts about whether hallucinogens have a therapeutic role in treating neurologic or behavioral disorders such ...
21 hours ago
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Natural plant compound may help overcome cancer drug resistance
A natural plant compound may help overcome a built-in defense that allows many cancers to resist a class of drugs designed to restore normal gene activity, according to a study by researchers at the Johns Hopkins Sidney Kimmel ...
12 hours ago
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Human dengue trial reveals how immune memory can help—or backfire
Spread through the bite of Aedes mosquitoes, dengue is a viral infection that can cause anything from mild fever, flu-like symptoms and joint pain to a severe form known as dengue hemorrhagic fever. What makes dengue particularly ...
A surge in brain connections fine-tunes visual responses within days of eyes opening, study finds
Our brain's wiring is shaped both by genes and what we experience, and the visual system is a great model for studying how the two work together. Before the eyes ever open, genetic programs lay down a first draft of the brain's ...
12 hours ago
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Cervical cancer cases and deaths forecast to rise
Global cervical cancer cases and deaths could rise by 20.2% and 39.3%, respectively, by 2050, according to a modeling study published in Nature Medicine. The findings suggest that the burden of cervical cancer will remain ...
14 hours ago
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No neuralyzer needed: The molecular pathways and circuit that trigger forgetting in C. elegans
In the 1997 film "Men in Black," one of the prominent pieces of alien technology the main characters use in their work to police extraterrestrial activity on Earth was the neuralyzer. This flashy handheld device would erase ...
13 hours ago
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How the immune system gets better at detecting pathogens
B cells, a type of white blood cell, protect our bodies by producing antibodies that recognize and bind to invaders like bacteria and viruses. After an infection, B cells undergo rapid mutations in the genes that encode antibodies. ...
16 hours ago
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Engineers address key hurdle for exhaled breath diagnostics
Chronic obstructive pulmonary disease (COPD), a chronic condition that causes increasing difficulty in breathing as it progresses, is the third leading cause of death worldwide. The clinical diagnosis and monitoring of COPD ...
16 hours ago
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RNA-protein interactions reveal new coronavirus drug targets
A study led by researchers at the University of California San Diego School of Medicine and University of California, Riverside (UCR) School of Medicine has identified new targets for antiviral drugs against coronaviruses, ...
17 hours ago
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Study provides reassuring news for women using medications to treat opioid use disorder during pregnancy
Pregnant patients receiving medication to treat opioid use disorder should not reduce their medication dose out of fear that it will worsen withdrawal symptoms in their newborns, according to a new study led by researchers ...
15 hours ago
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Researchers identify strategy to make pediatric bone cancers more vulnerable to immunotherapy
Ewing sarcoma is a rare and debilitating type of bone cancer affecting young adults and children. Despite intensive treatment with chemotherapy, surgery and radiation, many children do not overcome the disease.
17 hours ago
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Rapid genome sequencing helps guide care for about 50% of children with cancer
Two studies involving investigators at Cedars-Sinai Guerin Children's and the University of Cambridge, U.K., highlight the growing potential of whole-genome sequencing to transform the diagnosis and treatment of childhood ...
17 hours ago
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Quantum models predict lung cancer using limited training data in preliminary tests
Developing reliable machine learning models for health care can be challenging when only small datasets are available. This challenge motivates research into whether quantum computing approaches can learn useful patterns ...
18 hours ago
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New strategy may target common cancer driver with minimal side effects
Researchers have found a surprisingly common vulnerability in a broad variety of cancers and have begun designing drug compounds to exploit it, in a study led by investigators at Weill Cornell Medicine. The findings suggest ...
18 hours ago
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Enhancing the cell's natural recycling center improves Alzheimer's features in animal models
A defining feature of Alzheimer's disease is the abnormal, sustained accumulation of protein aggregates such as tau inside brain cells, which disrupts the cells' normal functions. As time passes, brain cells stop working ...
18 hours ago
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Could consciousness begin deep in the brain? Researchers make the case
Close your eyes and cover your ears. Much of the world around you disappears from view and hearing, yet your sense of being present, of being conscious, remains. What creates that basic feeling of being "you"?
20 hours ago
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Overtraining may disrupt the brain's dopamine regulation, leaving levels elevated during rest
Excessive physical exercise affects more than just the muscles; it can also alter brain chemistry. A new study published in the journal Neuroscience reveals that exhaustive training without adequate rest alters the regulation ...
20 hours ago
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