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Malaria parasite can reawaken after years: New vaccine target may block liver infection
University of South Florida researchers have discovered a previously unknown vulnerability in Plasmodium vivax (P. vivax), a malaria parasite that infects millions of people in Central and South America and Southeast Asia.
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Novel CAR-T therapy shows promising safety and durable responses in hard-to-treat multiple myeloma
A phase 1 clinical trial led by investigators at Mass General Brigham Cancer Institute and the University of Chicago Medicine Comprehensive Cancer Center has found that an investigational CAR-T therapy can lead to deep and ...
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Medical research news
Three heart cell receptors share unexpected signal that drives scar formation
Researchers at the Stanford Cardiovascular Institute have characterized an unexpected signaling pathway that helps drive cardiac fibrosis, the buildup of scar tissue that makes the heart stiffer and less able to pump normally. ...
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How a membrane lipid tunes the eye's response to light
Weill Cornell Medicine investigators have determined how a molecule within cells can help tune the eyes' sensitivity to light. The study identified the molecule's binding site on a protein in retinal cells, which should enable ...
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Dopamine prompts brain support cells to boost movement-control neurons, study suggests
A new Northwestern Medicine study challenges traditional ideas about how dopamine influences movement, according to findings published in Science Advances. The study, led by D. James Surmeier, Ph.D., the Nathan Smith Davis ...
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One gene helps drive growth in two childhood brain tumor groups that lack targeted therapies
Targeting KDM2B or downstream protein complexes it recruits may exploit a vulnerability in high-risk medulloblastoma subgroups that currently lack targeted therapies, according to a study led by St. Jude Children's Research ...
2 hours ago
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What your overnight blood pressure can reveal about your health
Most people's blood pressure falls by 10% to 20% while they sleep, giving the heart and blood vessels a chance to recover. But for some people, that nighttime dip never happens. Known as "non-dippers," these individuals face ...
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Gentle rhythmic tapping on shinbone helps injured brains heal faster in animal models
A traumatic brain injury (TBI) can turn a person's life upside down, leaving lasting effects on memory, thinking, physical abilities and overall quality of life. TBI remains one of the leading causes of death and disability ...
How specific changes in DNA shape human brain structure
Why do human brains vary in size and shape, and how did our brains expand over evolutionary time to give us our enhanced cognitive abilities? Researchers at the UNC Department of Genetics and the UNC Neuroscience Center have ...
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High-fat diet activates cellular repair pathway that helps colon cancer spread
Most colon cancer deaths are caused by the spread of tumor cells beyond the colon, usually to the liver. In a new study, MIT biologists identified a cellular pathway necessary for colorectal cancer metastasis.
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Astrocytes could help track the timing of frightening experiences
When the brain forms memories of past experiences, it typically encodes various information, including what happened, where it happened and the order in which events unfolded. The hippocampus is one of the primary brain regions ...
Food molecules transformed by gut bacteria and liver can still influence gene activity
The human liver and gut bacteria can alter molecules in food to influence signaling pathways that can activate or deactivate an array of genes, according to a new study led by researchers at Penn State.
3 hours ago
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Experimental chemotherapy uses stealth tactic to activate inside cancer cells
Chemotherapy faces a fundamental problem: The same drugs powerful enough to kill cancer cells can also damage healthy tissue. UC Irvine researchers are trying to change that equation by putting a safety lock on a highly potent ...
3 hours ago
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Brain-computer interface study sheds light on 'mirror neurons'
Scientists have known for years that neural activity in the brain's motor cortex doesn't just happen when people perform actions. Neurons associated with actions—reaching with a hand to grasp an object, for example—also fire ...
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Earlier stem cell transplants may improve survival in rare inherited bone marrow disorder
More than 90% of children born with the rare bone marrow condition Shwachman-Diamond syndrome (SDS) survive beyond age 20. But fewer than 30% live beyond age 50. Long-term survival could improve if clinicians act on early ...
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Older Americans are taking more medications, with 1 in 5 at risk for a major drug interaction
Older Americans are increasingly taking multiple prescription medications and dietary supplements. Although the prevalence of potentially major drug-drug interactions has declined slightly, more than 1 in 5 older adults are ...
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Nearly 1 in 5 people with sight loss report encountering bogus treatments
An international study of almost 1,000 people living with sight loss, led by University College London (UCL) researchers, found that nearly one in five reported receiving or encountering eye treatments they believed to be ...
5 hours ago
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Cellular 'energetic switch' could help separate drug rewards from natural pleasure
Alcohol, opioids, nicotine, cocaine and other addictive substances are known to influence the brain's reward system, the network of brain regions involved in the reinforcement of pleasure-seeking behaviors. Many of these ...
Smart contact lens detects serotonin changes in tear samples collected during stress test
A research team led by Dr. Yangzhi Zhu, principal investigator and assistant professor at the Terasaki Institute for Biomedical Innovation, has developed a soft, reusable smart contact lens as part of its broader Ocular Library ...
5 hours ago
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How the APOE4 gene damages brain blood vessels in Alzheimer's disease
Mount Sinai researchers have identified how APOE4, the strongest genetic risk factor for Alzheimer's disease, damages the brain's blood vessels and promotes the buildup of abnormal proteins linked to neurodegenerative disease. ...
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