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Sickle cell pain may involve previously unrecognized biological pathways
A small pilot study led by a Rutgers researcher has found differences in blood proteins between people experiencing high and low levels of pain from sickle cell disease, findings that may inform research on new treatments ...
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Medical research news
Blocking a nerve protein could interrupt chronic pain rather than simply mask it
Chronic pain can continue long after an initial injury. When a nerve outside the brain and spinal cord (a peripheral nerve) is damaged and does not heal properly, it keeps sending constant pain signals. Over time, this nonstop ...
3 hours ago
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Poor antibody validation wastes millions of biological samples, but solutions exist
A widespread failure to validate research antibodies before use is estimated to lead to the avoidable waste of millions of animal and human tissue samples worldwide, and an international expert panel has reached consensus ...
3 hours ago
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Tumor markers reveal which HER2+ breast cancer patients may respond to less intensive chemotherapy
The Journal of Clinical Oncology has published secondary results from the ECOG-ACRIN Cancer Research Group's CompassHER2-pCR clinical trial (EA1181, NCT04266249). The findings help identify which early-stage HER2-positive ...
2 hours ago
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Antifungal use during pregnancy shows link to altered hormone levels in babies
Many pregnant women develop fungal infections, which are often treated with widely used azole-based antifungal medicines. A new study involving researchers from the DTU National Food Institute and Copenhagen University Hospital ...
4 hours ago
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International study validates less invasive approach to diagnosing mitochondrial disease
Researchers at Children's Hospital Colorado (Children's Colorado) and the University of Colorado Anschutz School of Medicine have published one of the largest studies to date evaluating advanced laboratory testing for mitochondrial ...
5 hours ago
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Why chronic low back pain feels 'personal'
Low back pain is the single leading cause of disability worldwide, according to the World Health Organization. For people with chronic low back pain (cLBP) lasting more than 12 weeks, a sudden pain flare triggered by movement ...
5 hours ago
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Two studies link elevated ear protein levels in blood to tinnitus
When Dr. Kourosh Parham conceived a first-of-its-kind blood test for tinnitus, he knew further research was needed to confirm a link between a unique ear protein and the common hearing disorder. To validate his theory, the ...
6 hours ago
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Cell-free treatment reduces brain damage and improves recovery after stroke in mice
Ischemic stroke can leave lasting neurological damage after the initial vascular event, with oxidative stress, neuroinflammation, neuronal death and disruption of neural connectivity contributing to impaired recovery. Although ...
6 hours ago
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Promising nonopioid approach for reducing neuropathic pain disrupts a protein interaction
Understanding and treating chronic neuropathic pain has remained challenging due to its complex nature. New research from the lab of Clifford Woolf, MB, BCh, Ph.D., at Boston Children's Hospital's FM Kirby Neurobiology Center ...
6 hours ago
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Childhood obesity less common under new health-based definition
A new global definition of clinical obesity classifies far fewer children as obese than widely used body mass index (BMI) thresholds, according to a large international study. The findings could lead to changes in how childhood ...
7 hours ago
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Do you really need to fast before every blood test? New study suggests not
Even a routine blood test may come with an overnight fasting requirement. Many medical practices still ask patients to go without food for 8–12 hours before blood is drawn. While the protocol was originally recommended for ...
New insights into why the sun makes lupus patients sick
Researchers from University of Michigan Health have mapped the cellular path of inflammation after UV exposure in lupus patients.
4 hours ago
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Minimally invasive technique offers lasting relief for carpal tunnel syndrome
A minimally invasive ultrasound-guided technique offers long-term relief for patients with carpal tunnel syndrome with fewer side effects than steroids, according to a new study published in Radiology.
7 hours ago
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Even brief e-cigarette use can cause lasting lung damage and weaken defenses against respiratory viruses, study suggests
Just days of e-cigarette vapor exposure can injure the lungs' most delicate tissue and leave it more vulnerable to viral infection, according to a study led by National Jewish Health researchers and published in JCI Insight.
8 hours ago
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New HPV selection method could help develop more stable, easier-to-produce vaccines
It's recommended that all adolescents get vaccinated against human papillomavirus (HPV), as the infection can cause cancer. HPV causes nearly all cases of cervical cancer and about 70% of some forms of head and neck cancers. ...
8 hours ago
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Antimalarial drug persists in mosquitoes for days, potentially exposing developing parasites
Antimalarial drugs are designed to protect people from malaria, but they may also affect the mosquitoes exposed to them during blood meals. A new Yale study, published in The Journal of Infectious Diseases, investigates the ...
8 hours ago
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Cancer trial drug may work differently than scientists believed, raising concerns for clinical research
A cancer drug currently being tested in patients may have entered clinical trials based on an incorrect understanding of how it works, according to a new study led by the University of Sydney in collaboration with Goethe ...
12 hours ago
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Obesity's link to lower risk of death in dementia points to likely importance of nutrition
People who are overweight or obese when they are diagnosed with dementia are likely to live longer than those in a normal weight range, according to a new study by Columbia University Mailman School of Public Health and NYU ...
7 hours ago
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