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3D atomic-level snapshots reveal ketamine binds to human opioid receptors
Ketamine, a drug approved for medical use in 1970 as a short-acting anesthetic, including during the Vietnam War for battlefield surgery, is still a pharmacological mystery. For a long time, scientists knew that ketamine, ...
10 hours ago
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Immune cells may have a biological memory that makes weight loss harder after obesity
According to the World Health Organization, one in eight people lives with obesity. Yet despite numerous health education programs, books, articles and treatments, many individuals still struggle to lose weight once they ...
11 hours ago
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Medical research news
Night owls experience more mental health issues than early birds and take longer to recover from work
Balancing work and personal life is more challenging for evening types, or "night owls," than for morning types, or "early birds." Evening types have a harder time recovering from work and are more likely to have mental health ...
2 hours ago
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Scientists in France pinpoint why STING pathway hasn't been harnessed for cancer therapy yet
Deep within the cellular landscape, a quiet failure was taking place, impeding a potentially successful form of cancer treatment. For years, scientists hoped an essential part of the innate immune system that detects foreign ...
Lab-grown nerves match human sensory signal speeds, enabling tests of myelin repair
Rice University and collaborators in Switzerland have developed a platform to grow human-derived nerve cells and Schwann cells, supporting cells that form a protective coating called myelin around nerve fibers. This platform ...
8 hours ago
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Tumor 'floor plans' may predict immunotherapy response better than current biomarkers
Spatial transcriptomics is a powerful tool for creating a detailed map of not just how genes are expressed in a piece of tissue, but also where genetic activity takes place in different cells and locations within the tissue. ...
8 hours ago
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Scientists uncover microbiome signaling system that could open new paths for IBS-related constipation
Mayo Clinic researchers have discovered that chemical signals produced by gut bacteria work together to control intestinal movement. One bacterial signal helps set the intestines in motion, while another primes gut cells ...
11 hours ago
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Each breath is linked to brain activity, offering clues to epilepsy-related breathing failures
A new study led by researchers at the University of California San Diego shows that the brain does not simply respond to breathing as a steady rhythm. Instead, the detailed shape of each individual breath is closely linked ...
11 hours ago
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Breast density laws linked to higher ultrasound use after mammography
More than 40% of American women ages 40 and older have dense breast tissue, according to the National Cancer Institute. This type of tissue can make cancer harder to spot on mammograms and is itself associated with a higher ...
13 hours ago
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Computer vision 'sees' our organs age at different rates
We tend to think of age as a linear progression marked by birthdays and milestones dictating when we can vote, drink, rent a car or pass beyond the crest of an arbitrary metaphorical hill. When scientists look at how organs ...
12 hours ago
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Evidence often falls short in neuroscience reports of sex-dependent effects, analysis finds
Studies in the behavioral and brain sciences reporting a major sex-dependent effect—that a drug, treatment or other intervention is more effective in one sex than another—are supported by appropriate evidence less than 25% ...
9 hours ago
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Stress proteins actively sustain joint inflammation in osteoarthritis, study finds
Why do some joints remain chronically inflamed in osteoarthritis and other rheumatic diseases? Researchers have taken an important step toward answering this question. Their findings, published in the journal Cell Death & ...
12 hours ago
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A 'one-two punch' against aggressive breast cancer could offer an alternative to chemotherapy
Triple-negative breast cancer (TNBC) has a frustrating ability to adapt. Although this aggressive form of breast cancer can initially respond well to chemotherapy, cancer cells often find ways to survive, allowing the disease ...
13 hours ago
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Cancer's malignant remote control: How tumors reprogram liver fat metabolism to disarm immune cells
In their quest to understand how cancers take root, grow and spread, scientists have for the past half-century explored the genetic aberrations and microenvironmental peculiarities of tumors and their constituent cells. Such ...
12 hours ago
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T cell therapy shows promise in treating aggressive brain cancer
A new phase 1 clinical trial has found that an emerging immunotherapy is promising for treating recurrent glioblastoma, a highly aggressive and fatal brain cancer. Chimeric antigen receptor T (CAR-T) cell therapy is a form ...
14 hours ago
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Potent antiplatelet drugs increase major bleeding risk in AF patients after heart attack
Potent antiplatelet therapy increased bleeding without signs of benefit regarding cardiovascular events in patients with atrial fibrillation after a heart attack. This was the main finding of the EPIDAURUS trial presented ...
13 hours ago
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When danger becomes familiar, falling dopamine may free mice to pursue rewards
When an animal encounters a potential threat in its environment, it must focus completely on the danger to protect itself. But with repeated exposure, the threat becomes familiar and less important. The animal learns to adapt ...
14 hours ago
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Targeting protein synthesis control regions may reduce seizures in genetic epilepsy
Targeting the control of protein synthesis in the KCNQ2 gene may serve as a potential disease-modifying strategy for patients with a genetic form of neonatal-onset epilepsy and impaired brain development, according to a Northwestern ...
15 hours ago
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New AI method can support real-time management of infectious diseases
For the past 25 years, one discipline has been revolutionizing epidemiology: phylodynamics. By using genetic sequences, scientists can study how pathogens evolve. Thanks to mathematics, these data can be coherently organized ...
9 hours ago
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Scientists identify genes that could reduce APOE4 Alzheimer's disease risk
An international team of researchers led by Michael E. Belloy, Ph.D., an assistant professor of neurology and psychiatry at WashU Medicine, identified key genetic targets for developing potential Alzheimer's disease therapeutics. ...
9 hours ago
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