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Oncology & Cancer news
Oncology & Cancer
GDF-15 inhibitors show promise against hard-to-treat tumors in clinical trial
A multi-institutional clinical trial led by the University of Navarra, Spain, found that blocking growth differentiation factor 15 (GDF-15) can counteract resistance to anti-PD-1 and anti-PD-L1 therapies in solid tumors.
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Oncology & Cancer
Melanoma survival linked to tumor thickness
Researchers at The University of Sydney have identified a significant increase in melanoma-related death risk for patients with thin primary tumors measuring between 0.8 and 1.0 millimeters compared to those with thinner ...
9 hours ago
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HIF1α identified as crucial for T cell activation in oxygen-poor tumors
Immune checkpoint blockades, or ICBs, have revolutionized treatment for various advanced cancers. However, their effectiveness has plateaued due to therapeutic resistance that renders tumor-infiltrating lymphocytes, or TILs, ...
Dec 14, 2024
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Chemotherapy shortage did not increase cancer patient mortality
During a shortage of the generic platinum chemotherapy drugs cisplatin and carboplatin that began in early 2023, there was no difference in mortality rates among patients with advanced cancer compared to the previous year, ...
Dec 14, 2024
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Light-induced gene therapy disables cancer cells' mitochondria
Researchers are shining a light on cancer cells' energy centers—literally—to damage these power sources and trigger widespread cancer cell death. In a new study, scientists combined strategies to deliver energy-disrupting ...
Dec 13, 2024
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AI-powered blood test can spot earliest sign of breast cancer
A new screening method that combines laser analysis with a type of AI is the first of its kind to identify patients in the earliest stage of breast cancer, a study suggests.
Dec 13, 2024
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Molecular insights unlock a targeted approach to cancer immunotherapy
Australian-led research is unlocking new ways for immunotherapy to better target cancer. Cancer immunotherapy has revolutionized treatment for patients, whereby the body's own immune system is harnessed to destroy cancer ...
Dec 13, 2024
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Drug screening platform identifies compound for reinvigorating exhausted CAR-T cells
A research team led by Prof. Wang Haoyi from the Institute of Zoology (IOZ) of the Chinese Academy of Sciences has developed a chimeric antigen receptor T (CAR-T) cell exhaustion model and a functional screening platform ...
Dec 13, 2024
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Gut-immune connection could boost immunotherapy effectiveness in recurrent ovarian cancer
A study led by Roswell Park Comprehensive Cancer Center provides new insight into the complex interactions of the "tumor-immune-gut axis," and its role in influencing immunotherapy responses in patients with recurrent ovarian ...
Dec 13, 2024
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New immunotherapy platform has increased potential to target cancer cells
Researchers from Children's Hospital of Philadelphia (CHOP) and Stanford University have revealed the molecular structure of TRACeR-I, a protein platform for reprogramming immune responses.
Dec 13, 2024
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Pioneering MRI method spots pre-malignant pancreatic lesions for the first time
Precursor lesions of pancreatic cancer are very difficult to characterize with magnetic resonance imaging (MRI). But now, in a new study, researchers led by Noam Shemesh and Carlos Bilreiro—respectively, head of the Preclinical ...
Dec 13, 2024
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High-altitude gene variant linked to better blood cancer prognosis
Two researchers from Huntsman Cancer Institute at the University of Utah (the U) have discovered a gene variant found in high-altitude Andean populations that they believe could be a new biomarker for predicting the severity ...
Dec 13, 2024
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A low omega-6, omega-3 rich diet and fish oil may slow prostate cancer growth
A study led by UCLA Health Jonsson Comprehensive Cancer Center investigators offers new evidence that dietary changes may help reduce cancer cell growth in patients undergoing active surveillance, a treatment approach that ...
Dec 13, 2024
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SABCS: Omission of axillary staging noninferior for node-negative breast cancer
Omission of surgical axillary staging is noninferior to sentinel-lymph-node biopsy for patients with clinically node-negative, T1 or T2 invasive breast cancer, according to a study published online Dec. 12 in the New England ...
Dec 13, 2024
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Machine learning model predicts breast cancer treatment response
A machine learning (ML) model incorporating both clinical and genomic factors outperformed models based solely on either clinical or genomic data in predicting which patients with hormone receptor (HR)-positive, HER2-negative ...
Dec 13, 2024
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Mobile mammography boosts screening in underserved communities
A study by the Harvey L. Neiman Health Policy Institute demonstrates that mobile mammography is generally used by women otherwise unlikely to be screened, and thus is complementary to facility-based mammography rather than ...
Dec 13, 2024
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ZEST trial offers insights for using ctDNA to predict breast cancer recurrence
The ZEST clinical trial, designed to evaluate niraparib (Zejula) for the prevention of breast cancer recurrence in patients with circulating tumor DNA (ctDNA), failed to accrue enough patients positive for ctDNA, according ...
Dec 13, 2024
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High-risk breast cancer patients see improved outcomes with anthracyclines
Patients with early-stage, node-negative, hormone receptor (HR)-positive, HER2- negative breast cancer who have a high risk of recurrence based on the OncotypeDX genomic test had better outcomes when treated with adjuvant ...
Dec 13, 2024
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Q&A: Interplay between immune cells and HPV keeps skin healthy
Shadmehr (Shawn) Demehri, MD, Ph.D., of the Department of Dermatology and Center for Cancer Immunology at Massachusetts General Hospital, is the corresponding author of a paper published in Cancer Cell, "Commensal papillomavirus ...
Dec 13, 2024
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Heart-related side effects of cancer treatment must be addressed as early as possible, experts say
The devastating news of a cancer diagnosis understandably makes doctors and patients focus on the cancer itself. However, experts in cardio-oncology from the European Society of Cardiology (ESC) emphasize that heart and cardiovascular ...
Dec 13, 2024
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AI's role in cancer research: Review highlights advantages and limitations
Significant advancements in understanding the molecular and cellular mechanisms of tumor progression have been made, yet challenges remain. Traditional imaging techniques like MRI, CT, and mammography are limited by the need ...
Dec 13, 2024
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Why copper could be key to treating a rare childhood cancer
The survival rate for children with a rare but deadly cancer could one day be improved by adding an existing drug—which is currently used to manage excess copper in the body—to their treatment.
Dec 12, 2024
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Early-onset colorectal cancer cases are surging, global study finds
A new study led by American Cancer Society (ACS) researchers shows that early-onset colorectal cancer (CRC) incidence rates are rising in 27 of 50 countries/territories worldwide, 20 of which have either exclusive or faster ...
Dec 12, 2024
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Brain tumors hijack the circadian clock to grow, research shows
Virtually every cell in the human body has an internal clock. These clocks take their cues from a central clock in the brain. In a normal, biological process called synchrony, the central clock coordinates daily rhythms around ...
Dec 12, 2024
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Kinder chemo: New regimen offers hope for Hodgkin lymphoma patients
A simple change to the chemotherapy regimen for people with Hodgkin lymphoma could reduce the long-term health impacts that can result from treatment, according to researchers in Cambridge. The findings could lead to the ...
Dec 12, 2024
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