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Oncology & Cancer news
Oncology & Cancer
A 20-year study may upend long-held theory about chromosomes and cancer
Johns Hopkins Medicine scientists say their 20-year study of more than 200 people with premature aging syndromes caused by abnormally short telomeres, or shortened repetitive DNA sequences at the ends of chromosomes, may ...
6 hours ago
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New breast cancer susceptibility gene candidate identified
A paper published in the American Journal of Human Genetics proposes ATRIP gene variants as a breast cancer susceptibility gene candidate based on a study of women without any of the known breast cancer-associated gene variants.
Allies or enemies of cancer: The dual fate of neutrophils
Why do cancer immunotherapies work so extraordinarily well in a minority of patients, but fail in so many others? By analyzing the role of neutrophils, immune cells whose presence usually signals treatment failure, scientists ...
11 hours ago
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New immunotherapy delivery approach safe and beneficial for some melanoma patients with leptomeningeal disease
A novel approach to administer intrathecal (IT) immunotherapy (directly into the spinal fluid) and intravenous (IV) immunotherapy was safe and improved survival in a subset of patients with leptomeningeal disease (LMD) from ...
11 hours ago
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The role of lipids in blood cancer: New insights into uncharted territory
Cells contain diverse populations of molecules called lipids, which are organic fatty compounds. Lipid metabolism, the synthesis and breakdown of these lipids, plays a key role in regulating the composition and functions ...
11 hours ago
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Validation of a therapy that overcomes chemotherapy resistance in colon and rectal cancer
A multidisciplinary team made up of doctors and scientists from the Hospital del Mar Medical Research Institute (IMIM-Hospital del Mar) and the Institute for Research in Biomedicine (IRB Barcelona) has led a study, recently ...
13 hours ago
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Surgery proves effective alternative to chemotherapy and radiation for early metastatic testicular cancer
A newly published study paves the way for some patients with testicular cancer to avoid chemotherapy and radiation.
9 hours ago
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Breast cancer screenings of at-risk women dropped after revised mammography guidelines issued in 2009: Study
In 2009, the U.S. Preventive Services Task Force changed its mammography screening guidelines to recommend that routine breast cancer screening start at age 50 rather than age 40, recommending an individualized approach for ...
9 hours ago
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A promising outlook: CAR T cell therapy improves patient quality of life
Chimeric antigen receptor T-cell (CAR-T) therapy has transformed cancer treatment, yet relatively few studies have investigated the impact of the therapy on longitudinal patient quality of life—an aspect of care that often ...
12 hours ago
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Pathogenic genetic variations found to boost the risk of H. pylori–related stomach cancer
A large case-control study by international researchers at the RIKEN Center for Integrative Medical Sciences (IMS) in Japan has found that people who carry certain genetic risk factors for gastric (stomach) cancer have a ...
Mar 29, 2023
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Scientists identify cellular signaling pathway as key player in metastasis
A team of scientists at the Sloan Kettering Institute have identified the STING cellular signaling pathway as a key player in keeping dormant cancer cells from progressing into aggressive tumors months, or even years, after ...
Mar 29, 2023
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Sox9 protein enables molecular 'time travel' that can lead to colorectal cancer
Normally the lining of the colon forms a series of steep hills and valleys. At the surface, where the hills peak, are functional colon cells that do the organ's work of absorption and secretion. Deep in the valleys are stem ...
Mar 29, 2023
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Novel lymphoma tumor model paves way for new therapies
In recent years, innovative cancer drugs that target specific molecular drivers of the disease have been embraced as the treatment of choice for many types of cancer. But despite significant advances, there is still a lack ...
Mar 29, 2023
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Predicting neuroblastoma outcomes with molecular evolution
A research team led by the German Cancer Research Center in Heidelberg, Germany, has discovered that the genetic sequence of a tumor can be read like a molecular clock, traced back to its most recent common ancestor cell. ...
Discovery could be key to reducing leukemia treatment resistance
In a world first, Newcastle researchers have discovered the mechanisms acute myeloid leukemia (AML) cells use to produce "free radicals"—the byproduct of a cell process that aggressively fuels the growth of cancer cells ...
Mar 29, 2023
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How a rogue protein produces 'Dr. Jekyll and Mr. Hyde' cancer cells
Melbourne researchers have discovered how a rogue protein produces "Dr. Jekyll and Mr. Hyde" cancer cells, which could lead to improved treatments for melanoma and other cancers.
Mar 29, 2023
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A promising strategy to combat tumor cells by targeting combination of cellular mechanisms
After attacking a tumor with a targeted therapy, the cancer might stagger but often comes back fighting—usually even harder to defeat. University of Saskatchewan (USask)-led research has revealed a promising strategy to ...
Mar 29, 2023
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Researchers develop new method to make bone marrow transplants safer and more effective
A groundbreaking process developed by researchers based in the Roy Blunt NextGen Precision Health Building is offering new hope in the fight against blood cancers, such as lymphoma and leukemia.
Mar 29, 2023
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Immune checkpoint inhibitor antitumor response: Decoding molecular mechanisms
Immune checkpoint inhibitors (ICIs) are widely sought after for the treatment of different types of cancers. Unfortunately, only 20%–30% patients with cancer respond to ICI treatment. Although the factors that influence ...
Mar 29, 2023
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