Oncology & Cancer

Mapping genetic variants driving toxicity to leukemia therapy

Scientists at St. Jude Children's Research Hospital, alongside collaborators around the world, have created a comprehensive reference of functional variants in an important drug-metabolizing enzyme called NUDT15. This thorough ...

Oncology & Cancer

Too much of a good thing may lead to too much of a liver as well

All life is challenged by oxidants—reactive molecules or compounds that remove electrons from other molecules—often with adverse effect, commonly referred to as oxidative stress. Consequently, all organisms have evolved ...

Oncology & Cancer

Extra chromosomes in cancers can be good or bad

Cancer cells are notorious for their genetic disarray. A tumor cell can contain an abundance of DNA mutations and most have the wrong number of chromosomes. A missing or extra copy of a single chromosome creates an imbalance ...

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