Genetic toolkit uses mouse models to modify and investigate gene function
A team at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) has developed a comprehensive set of innovative genetic tools and mouse lines, called iFlpMosaics, designed to enhance the study of gene function and ...
Dec 13, 2024
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Limiting intake of a non-essential amino acid brings surprising benefits in fruit fly study
Feeding female fruit flies a diet low in the amino acid tyrosine improves their ability to endure food shortage, reduces their reproductive output, and causes them to live longer, RIKEN researchers have found. The findings, ...
Dec 12, 2024
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Tiny sensors offer new hope for faster bone injury recovery
Tiny implantable sensors are helping University of Oregon researchers optimize the process of recovery from severe bone injuries.
Dec 12, 2024
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Women born prematurely have a greater suicide risk, study suggests
Not only are they the smallest among us, but premature children also face health and life challenges that make them the most vulnerable. Generally speaking, they have a slightly higher risk of mortality due to illness. It ...
Dec 12, 2024
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Studies reveal evolution of paramagnetic rim lesions in MS
In recent years, researchers studying multiple sclerosis have concluded that white matter lesion volume in the brain, long considered the best way to monitor MS disease progression, may not be the most accurate predictor ...
Dec 12, 2024
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First full characterization of kidney microbiome unlocks potential to prevent kidney stones
Cleveland Clinic researchers have found definitive proof of a kidney microbiome that influences renal health and kidney stone formation, demonstrating that the urinary tract is not sterile and low levels of bacteria are normal.
Dec 11, 2024
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New path toward faster drug approvals for multiple myeloma treatment
A new review published in Blood Cancer Discovery outlines a major multiple myeloma research project that supported a key regulatory decision by a U.S. Food and Drug Administration committee. The decision greenlights a new ...
Dec 11, 2024
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Hypovolemic phlebotomy beneficial before liver resection
For patients undergoing liver resection, hypovolemic phlebotomy reduces perioperative red blood cell transfusions compared with usual care, according to a study published online Dec. 9 in The Lancet Gastroenterology and Hepatology.
Dec 11, 2024
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Psychedelic therapy research calls for better reporting
Psychedelic-assisted psychotherapy is gaining attention as a promising approach to treat patients with mental disorders for whom conventional treatments have been insufficient. A new collaborative study by researchers at ...
Dec 10, 2024
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Scientists reveal how COVID-19 variants hijack human cells
Scientists at the University of Helsinki, University of Eastern Finland and University of Turku are investigating the intricate ways in which various SARS-CoV-2 variants, like delta and omicron, interact with human cells ...
Dec 10, 2024
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Blood transfusions for brain bleeding: Large trial adds to debate about optimal threshold
Blood is one of the oldest drugs in the world, but after many decades of research, it is still not always clear when a blood transfusion should be given. A large trial published in the New England Journal of Medicine is adding ...
Dec 10, 2024
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Gene variant linked to reduced thiopurine metabolism in African ancestry
Mayo Clinic researchers found that a gene variant, the TPMT∗8 allele, is associated with reduced metabolism of the thiopurine class of drugs. TPMT∗8 is relatively common in individuals of African or African American descent.
Dec 10, 2024
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Itacitinib helps prevent graft versus host disease in stem cell transplant recipients
For patients with haploidentical hematopoietic cell transplantation (haplo-HCT), the addition of itacitinib to standard graft versus host disease (GvHD) prophylaxis is well tolerated and results in low rates of cytokine release ...
Dec 10, 2024
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Molecular strategy used by worm parasites to evade host immune defenses has therapeutic potential
Helminths are known for their remarkable ability to regulate host immune responses, a trait that has intrigued scientists for its therapeutic potential. However, the mechanism behind this phenomenon has remained elusive. ...
Dec 9, 2024
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First mouse strain susceptible to severe COVID-19 without the need for genetic modification identified
Researchers at The Jackson Laboratory and Trudeau Institute have identified the first mouse strain that is susceptible to severe COVID-19 without the need for genetic modification. This development, reported in Scientific ...
Dec 6, 2024
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Gut microbiota: A consensus paper to regulate the 'wild west' of diagnostic tests
The gut microbiota might perhaps one day become a routine tool for the early diagnosis of many diseases and to guide treatment, but at present there is a lack of solid scientific evidence to support these claims. Yet, day ...
Dec 6, 2024
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New method of drug discovery and development offers better understanding of how drugs work
According to a new study published in Nature Communications, researchers at the Department of Laboratory Medicine, Karolinska Institutet, have made a significant leap in drug discovery and development with a new method called ...
Dec 6, 2024
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Scientists discover new receptor for nerve growth factor—a promising target for treating pain
Researchers at the NYU Pain Research Center have found a new receptor for nerve growth factor that plays an important role in pain signaling, even though it does not signal on its own, according to a study published in the ...
Dec 5, 2024
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Potential molecular therapy reverses placental development issues in mice
A signal that the body adds to an mRNA can disrupt placental development and lead to fetal growth restriction (FGR). In this condition, a fetus is smaller than expected for its age during pregnancy and complications such ...
Dec 5, 2024
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Rules-based electronic triggers effectively ID missed opportunities in diagnosis
Rules-based electronic triggers (e-triggers) are useful for post hoc detection of missed opportunities in diagnosis (MODs) in emergency department visits, according to a study published online Dec. 2 in JAMA Internal Medicine.
Dec 5, 2024
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Unexpected discovery revives abandoned breast cancer treatment
A recent study led by Lund University in Sweden has found that some patients with aggressive breast cancer can be helped by a targeted cancer treatment that had been under development but was shelved. The study is important ...
Dec 4, 2024
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Bioprinting technique creates functional tissue 10x faster
Three-dimensional (3D) printing isn't just a way to produce material products quickly. It also offers researchers a way to develop replicas of human tissue that could be used to improve human health, such as building organs ...
Dec 3, 2024
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Unraveling the viral puzzle of why humans are susceptible to hepatitis B virus, but monkeys are not
Hepatitis B virus (HBV) infection is a leading cause of chronic liver diseases that spreads among individuals through blood or body fluids. According to the World Health Organization, globally, 1.2 million new HBV infections ...
Dec 3, 2024
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