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Uncuffing nitric oxide production: Beta-arrestin2 complexes regulate NO levels

The liver filters blood, detoxifies chemicals and metabolizes drugs. Hepatitis, alcohol and primary liver diseases are common sources of damage in the liver and can result in scarring, known as fibrosis. Long-term fibrosis ...

Medical research

Eat less and live a long healthy life? Study shows 'not in all cases'

An underlying assumption of research on aging holds that dietary restriction (and drugs that mimic its effects) will slow aging to extend both lifespan and healthspan jointly. While eating a Spartan diet has been shown to ...

Medical research

Researchers deconstruct tissue repair

ETH researchers have deconstructed the mechanisms that control wound healing and scar formation in more detail. To this end, biologists and engineers have developed a new method that allows the biomechanical properties of ...

Medical research

How a microRNA protects vascular integrity

Short RNA molecules known as microRNAs (miRNAs) play a vital role in the regulation of gene expression. Anomalies in miRNAs expression and function have been implicated in pathological processes, such as the development of ...

Medical research

Researcher calls for one-person trials for personalized medicine

"All things are poison, and nothing is without poison, the dosage alone makes it so a thing is not a poison." These were the words of Paracelsus, a Swiss physician who recognized back in the 16th century that every medicine ...

Medical research

Researchers grow hairy skin from human stem cells

Building on years of groundbreaking discoveries in stem cell research, scientists from Indiana University School of Medicine and Harvard Medical School have determined how to grow hairy skin using human stem cells—developing ...

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Researchers find new way to detect blood clots

Researchers in the Department of Biomedical Engineering at Texas A&M University are working on an entirely new way to detect blood clots, especially in pediatric patients.

Medical research

Engineered T cells for type 1 diabetes move closer to clinic

For much of the last decade, Dr. David Rawlings, director of Seattle Children's Research Institute's Center for Immunity and Immunotherapies, has dreamed of developing a therapy for children with type 1 diabetes that doesn't ...

Medical research

'Terminator' protein halts cancer-causing cellular processes

Essential processes in mammalian cells are controlled by proteins called transcription factors. For example, the transcription factor HIF-1 is triggered by a low-oxygen situation to cause the cell to adapt to decreased oxygen.

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A faster way to make antibody-drug conjugates

A USC School of Pharmacy-led team has engineered a new, faster way to make drugs that precisely target malignant cells—while leaving healthy tissue undamaged—that could lead the way to better treatments for numerous types ...

Medical research

Platform precisely quantifies antigens presented on cell surfaces

Normally, the immune system is able to differentiate between healthy and abnormal cells. Peptides, fragments created by the synthesis and breakdown of proteins inside each cell, are presented on the surface as antigens and ...