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Uncuffing nitric oxide production: Beta-arrestin2 complexes regulate NO levels

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Uncuffing nitric oxide production: Beta-arrestin2 complexes regulate NO levels

The liver filters blood, detoxifies chemicals and metabolizes drugs. Hepatitis, alcohol and primary liver diseases are common sources of damage in the liver and can result in scarring, known as fibrosis. Long-term fibrosis ...

12 hours ago

Medical research

Eat less and live a long healthy life? Study shows 'not in all cases'

An underlying assumption of research on aging holds that dietary restriction (and drugs that mimic its effects) will slow aging to extend both lifespan and healthspan jointly. While eating a Spartan diet has been shown to ...

17 hours ago

Medical research

High-protein diets help insects to fight against blood parasites

Scientists studying insects have identified a crucial biological mechanism responsible for increasing their survival against blood parasites.

17 hours ago

Medical research

Researchers discover new member of novel drug family for 'undruggable' targets

In the last several years, excitement has surged for a promising class of drugs that work not by inhibiting the action of a molecular target, as most conventional drugs do, but instead by harnessing the cell's recycling system ...

17 hours ago

Medical research

Researchers deconstruct tissue repair

ETH researchers have deconstructed the mechanisms that control wound healing and scar formation in more detail. To this end, biologists and engineers have developed a new method that allows the biomechanical properties of ...

22 hours ago

Medical research

How a microRNA protects vascular integrity

Short RNA molecules known as microRNAs (miRNAs) play a vital role in the regulation of gene expression. Anomalies in miRNAs expression and function have been implicated in pathological processes, such as the development of ...

17 hours ago

Medical research

Researcher calls for one-person trials for personalized medicine

"All things are poison, and nothing is without poison, the dosage alone makes it so a thing is not a poison." These were the words of Paracelsus, a Swiss physician who recognized back in the 16th century that every medicine ...

19 hours ago

Medical research

Researchers grow hairy skin from human stem cells

Building on years of groundbreaking discoveries in stem cell research, scientists from Indiana University School of Medicine and Harvard Medical School have determined how to grow hairy skin using human stem cells—developing ...

Jun 04, 2020

Medical research

Researchers find new way to detect blood clots

Researchers in the Department of Biomedical Engineering at Texas A&M University are working on an entirely new way to detect blood clots, especially in pediatric patients.

Jun 04, 2020

Medical research

In a first, researchers use base editing to correct recessive genetic deafness and restore partial hearing to mice

When Wei Hsi (Ariel) Yeh was a young undergraduate student, one of her close friends went from normal hearing to complete deafness in the span of one month. He was 29 years old. No one knew why he lost his hearing; doctors ...

Jun 03, 2020

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Medical research

Engineered T cells for type 1 diabetes move closer to clinic

For much of the last decade, Dr. David Rawlings, director of Seattle Children's Research Institute's Center for Immunity and Immunotherapies, has dreamed of developing a therapy for children with type 1 diabetes that doesn't ...

Jun 03, 2020

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Medical research

'Terminator' protein halts cancer-causing cellular processes

Essential processes in mammalian cells are controlled by proteins called transcription factors. For example, the transcription factor HIF-1 is triggered by a low-oxygen situation to cause the cell to adapt to decreased oxygen.

Jun 03, 2020

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Medical research

A faster way to make antibody-drug conjugates

A USC School of Pharmacy-led team has engineered a new, faster way to make drugs that precisely target malignant cells—while leaving healthy tissue undamaged—that could lead the way to better treatments for numerous types ...

Jun 03, 2020

Medical research

App determines COVID-19 disease severity using artificial intelligence, biomarkers

A new mobile app can help clinicians determine which patients with the novel coronavirus (COVID-19) are likely to have severe cases. Created by researchers at NYU College of Dentistry, the app uses artificial intelligence ...

Jun 03, 2020

Medical research

Researchers identify secretion mechanisms for a protein necessary for maintaining healthy connective tissues

Researchers have discovered that a defective form of the protein aortic carboxypeptidase-like protein (ACLP) from patients with Ehlers-Danlos syndrome (EDS) is retained in cells and induces cellular stress. This finding may ...

Jun 03, 2020

Medical research

The fascinating history of clinical trials

Clinical trials are under way around the world, including in Australia, testing COVID-19 vaccines and treatments.

Jun 03, 2020

Medical research

Researchers find some hair greying is due to stress and thus can be reversed

A team of researchers at Columbia University, collaborating with an associate at the University of Miami Miller School of Medicine, has found evidence of human hair turning grey due to stress and then reverting to its natural ...

Jun 02, 2020 report

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Medical research

Platform precisely quantifies antigens presented on cell surfaces

Normally, the immune system is able to differentiate between healthy and abnormal cells. Peptides, fragments created by the synthesis and breakdown of proteins inside each cell, are presented on the surface as antigens and ...

Jun 02, 2020

Medical research

COVID-19 drug development could benefit from approach used against flu

A new study from researchers at The University of Texas at Austin has found that some antivirals are useful for more than helping sick people get better—they also can prevent thousands of deaths and hundreds of thousands ...

Jun 02, 2020

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Medical research

Lab-grown miniature human livers successfully transplanted in rats

Using skin cells from human volunteers, researchers at the University of Pittsburgh School of Medicine have created fully functional mini livers, which they then transplanted into rats.

Jun 02, 2020

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