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Immunology news
Oncology & Cancer
HIF1α identified as crucial for T cell activation in oxygen-poor tumors
Immune checkpoint blockades, or ICBs, have revolutionized treatment for various advanced cancers. However, their effectiveness has plateaued due to therapeutic resistance that renders tumor-infiltrating lymphocytes, or TILs, ...
14 hours ago
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Oncology & Cancer
Molecular insights unlock a targeted approach to cancer immunotherapy
Australian-led research is unlocking new ways for immunotherapy to better target cancer. Cancer immunotherapy has revolutionized treatment for patients, whereby the body's own immune system is harnessed to destroy cancer ...
Dec 13, 2024
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Drug screening platform identifies compound for reinvigorating exhausted CAR-T cells
A research team led by Prof. Wang Haoyi from the Institute of Zoology (IOZ) of the Chinese Academy of Sciences has developed a chimeric antigen receptor T (CAR-T) cell exhaustion model and a functional screening platform ...
Dec 13, 2024
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Gut-immune connection could boost immunotherapy effectiveness in recurrent ovarian cancer
A study led by Roswell Park Comprehensive Cancer Center provides new insight into the complex interactions of the "tumor-immune-gut axis," and its role in influencing immunotherapy responses in patients with recurrent ovarian ...
Dec 13, 2024
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New immunotherapy platform has increased potential to target cancer cells
Researchers from Children's Hospital of Philadelphia (CHOP) and Stanford University have revealed the molecular structure of TRACeR-I, a protein platform for reprogramming immune responses.
Dec 13, 2024
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Q&A: Interplay between immune cells and HPV keeps skin healthy
Shadmehr (Shawn) Demehri, MD, Ph.D., of the Department of Dermatology and Center for Cancer Immunology at Massachusetts General Hospital, is the corresponding author of a paper published in Cancer Cell, "Commensal papillomavirus ...
Dec 13, 2024
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Why copper could be key to treating a rare childhood cancer
The survival rate for children with a rare but deadly cancer could one day be improved by adding an existing drug—which is currently used to manage excess copper in the body—to their treatment.
Dec 12, 2024
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Immune system 'tuning dial' sheds light on why COVID makes some sicker than others
Why does the COVID-19 virus make some people sicker than others? For years, scientists have looked to a critical piece of immune system machinery—known as the interferon pathway—for answers. There, when our cells sense ...
Dec 12, 2024
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Scientists establish novel link between T cell nutrition and identity
The decision between scrambled eggs or an apple for breakfast probably won't make or break your day. However, for your cells, a decision between similar microscopic nutrients could determine their entire identity. If and ...
Dec 12, 2024
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Non-tumor cells in pancreatic cancer may reduce the effectiveness of the body's natural immune response
The relationship the immune system and stromal cells in pancreatic cancer can have a significant impact on patients' survival rates, according to findings of a Queen Mary-led study.
Dec 12, 2024
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Computational model advances rational design of more effective maternal vaccines for newborns
Newborns, with their developing immune systems, face high risks of infection in the critical early months of life. While maternal vaccines can bolster infant immunity by delivering antibodies through the placenta, these vaccines ...
Dec 12, 2024
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New drug strategy targets rare immune disorders' genetic roots
Several rare immune disorders are caused by mutations in the patient's DNA. In a new study published in the Journal of Clinical Immunology, the University of Surrey and its collaborators found that targeting the mutated pathways ...
Dec 12, 2024
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A new way to treat inflammatory skin conditions: Experimental compound targets mast cells
A new approach to treat rosacea and other inflammatory skin conditions could be on the horizon, according to a University of Pittsburgh study published in Science Translational Medicine.
Dec 11, 2024
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Protein discovery illuminates how the immune system switches between rest and action
Cells in the immune system don't always fight; they often rest and wait for threats, like viruses or bacteria. When such threats emerge, the cells activate to defend the body. This delicate balance between rest and activation ...
Dec 11, 2024
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Scientists transform ubiquitous skin bacterium into a topical vaccine
Imagine a world in which a vaccine is a cream you rub onto your skin instead of a needle a health care worker pushes into one of your muscles. Even better, it's entirely pain-free and not followed by fever, swelling, redness ...
Dec 11, 2024
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Tumors grow larger in female fruit flies than males. Here's what that could mean for humans
A study by Tulane University researchers has uncovered new insights into how biological sex differences can influence tumor growth. The findings, published in Science Advances, could lead to a better understanding of cancer ...
Dec 11, 2024
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Cancer therapy shows long-term survival benefits for patients with high-risk, BRCA-positive breast cancer in trial
Patients with high-risk, BRCA-positive breast cancer who received olaparib (Lynparza) after standard treatment continued to have better survival outcomes than those who received placebo after a median follow-up of 6.1 years, ...
Dec 11, 2024
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How this cancer drug could make radiation a slam dunk therapy
Radiation is one of the most effective ways to kill a tumor. But these therapies are indiscriminate, and they can damage healthy tissues.
Dec 10, 2024
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How chemotherapy primes ovarian cancer for immune-based therapies
Researchers have discovered how chemotherapy can change tumors, making them more vulnerable to new types of treatments. These findings could lead to personalized therapies that target the right patients at the right time, ...
Dec 10, 2024
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'Missing link' between brain and body inflammatory signals identified in the skull
Research from the Institute of Psychiatry, Psychology & Neuroscience (IoPPN) at King's College London provides valuable insights into the brain-body immune connection, identifying key communication hubs in the dural sinuses ...
Dec 10, 2024
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Researchers explore role of mechanical force in immune responses of a rare genetic disorder
A firm handshake between proteins on immune cells is important for the body's ability to fight infection. Meanwhile, a weak grip helps explain the poor immune deficiencies caused by a rare genetic disorder.
Dec 10, 2024
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New treatment may delay cancer in high-risk myeloma
A new treatment is showing promise for people with high-risk smoldering multiple myeloma (SMM). This precancerous condition can progress to active multiple myeloma, a type of blood cancer. High-risk SMM carries a higher likelihood ...
Dec 10, 2024
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Trial finds monoclonal antibody therapy improves survival in cancer-associated hyper-inflammatory disorder
Adult patients with newly diagnosed malignancy-associated hemophagocytic lymphohistiocytosis (mHLH)—a rare, aggressive hyperinflammatory condition—who were treated with the first-in-class monoclonal antibody, ELA026, ...
Dec 10, 2024
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New study first step in understanding current practice patterns of treatment for sarcoidosis
Sarcoidosis is a multi-systemic disease of unknown etiology with a clinical presentation ranging from asymptomatic disease to organ failure. While some patients with sarcoidosis have spontaneous disease remission, others ...
Dec 10, 2024
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Venetoclax could improve outcomes of CAR T therapy for patients with resistant B-cell lymphomas
About a third of patients with diffuse large B cell lymphoma (DLBCL), a fast-growing form of lymphoma, will see their disease advance or recur following treatment. Seeking a new treatment strategy that might boost the effectiveness ...
Dec 10, 2024
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