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Immunology news
Diseases, Conditions, Syndromes
New monoclonal antibody prevents malaria infection in early clinical trial
Malaria remains one of the leading causes of death among children in sub-Saharan Africa, claiming more than 600,000 lives each year worldwide with limited efficacy in currently available treatments and vaccines. Now a new ...
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Immunology
How immune cells deliver their deadly cargo: An unexpected connection to lipid metabolism
When immune cells strike, precision is everything. New research reveals how natural killer and T cells orchestrate the release of toxic granules—microscopic packages that destroy virus-infected or cancerous cells.
Oct 17, 2025
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Supercharging immune cells to fight drug resistant bowel cancer
Scientists at University College London have engineered a rare type of immune cell to kill slow-growing bowel cancer cells that are resistant to current therapies, a breakthrough that could lead to new treatments in the future.
Oct 17, 2025
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'Craters' on surface of melanoma cells mark tumor-killing hotspots, study reveals
New research published in Cell finds the existence of craters on the surface of melanoma cells that serve as immune hubs, becoming major sites for tumor killing. These craters could serve as good markers for immunotherapy ...
Oct 17, 2025
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Surprising gene mutation in brain's immune cells linked to increased Alzheimer's risk
In a study published in Neuron, a research team at the Department of Neurology at Massachusetts General Hospital, aimed to understand how immune cells of the brain, called microglia, contribute to Alzheimer's disease (AD) ...
Oct 17, 2025
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A missing protein may hold key to rejuvenating aging blood cells
As our hair goes gray and our muscles weaken with age, our immune system also changes. In particular, the stem cells that become blood or immune cells can develop mutations, potentially leading to cancers or other dysfunctions.
Oct 16, 2025
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How bacteria in tumors drive treatment resistance in cancer
Researchers from The University of Texas MD Anderson Cancer Center have discovered a previously unknown mechanism that explains how bacteria can drive treatment resistance in patients with oral and colorectal cancer. The ...
Oct 16, 2025
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Crucial protein enables immune system memory
Researchers at the University of Missouri School of Medicine have recently found that a certain protein may have a large influence on how the immune system functions.
Oct 16, 2025
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Modified virus boosts cancer vaccine effectiveness in mouse experiments
Could a future vaccine against cancer be made better by an immune-boosting virus? Very likely, say Canadian scientists, who've proven its effectiveness in experiments on mice.
Oct 16, 2025
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Cancer patients' thymic health is linked to their response to immunotherapy
In cancer patients, the health of the thymus—a key part of the body's immune system—is associated with the outcomes these patients experience after immune checkpoint inhibitor treatment, according to an international ...
Oct 16, 2025
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Biomarker analysis reveals clues to long-term survival in glioblastoma patients treated with SurVaxM
Results of a study led by researchers at Roswell Park Comprehensive Cancer Center are shedding light on why some newly diagnosed glioblastoma patients survive longer than others after receiving standard treatment in conjunction ...
Oct 16, 2025
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Moderate-dose corticosteroid treatment found to improve patient recovery rates from sepsis
While our immune systems typically do a great job containing pathogens and clearing infections, they can occasionally overreact. When the immune response to infection becomes excessive, it causes rapid, widespread organ damage ...
Oct 16, 2025
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Gene therapy delivers lasting immune protection in children with rare disorder
An experimental gene therapy developed by researchers at UCLA, University College London and Great Ormond Street Hospital has restored and maintained immune system function in 59 of 62 children born with ADA-SCID, a rare ...
Oct 15, 2025
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Checkpoint inhibitor promotes tissue repair, offering hope for chronic wound treatment
Immune checkpoint inhibitors are well known as a form of cancer treatment. Researchers at UZH have now identified a new, important function of these inhibitors: promotion of tissue healing. This finding could help advance ...
Oct 15, 2025
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Immunotherapy approach offers hope for long-term HIV control without daily medication
HIV remains a major global health issue, affecting nearly 40 million people worldwide. Current treatments, known as antiretroviral therapy (ART), are highly effective at suppressing the virus and preventing illness, but they ...
Oct 15, 2025
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Immune cell subtype in multiple sclerosis patients may enable targeted treatment
Multiple sclerosis, which affects around one in 500 people in Switzerland, is an autoimmune disease in which immune cells attack the central nervous system, causing irreversible damage. Current treatments involve blocking ...
Oct 15, 2025
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Conversion of IgG antibodies to IgM broadens antibacterial activity
Researchers at UMC Utrecht have discovered that converting monoclonal antibodies from the IgG to the IgM isotype can significantly broaden their ability to recognize and bind multiple human-relevant bacterial pathogens. The ...
Oct 15, 2025
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Novel combination therapy shows promise for aggressive lymphoma resistant to immunotherapy
A study published in Cancer Discovery finds that combining an epigenetic therapy with an anti-PD-1 antibody, which uses the body's natural response to viral infections, shows promising results in patients with relapsed or ...
Oct 15, 2025
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SGLT-2 diabetes drugs linked to lower risk of autoimmune diseases
Sodium-glucose cotransporter-2 (SGLT-2) inhibitors used to treat type 2 diabetes are associated with an 11% lower risk of autoimmune rheumatic diseases, such as rheumatoid arthritis and lupus, compared with another group ...
Oct 15, 2025
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Human liver organoid platform can predict immune-mediated drug toxicity
Researchers at Cincinnati Children's Hospital Medical Center in collaboration with Roche, have developed a next-generation human liver organoid microarray platform that could help predict which drugs may cause harmful immune ...
Oct 14, 2025
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mRNA directs body to produce nanobodies that unlock immune attack on colorectal cancer tumors
A tiny molecule called a nanobody may succeed where today's cancer drugs often fail, according to University of Hawaiʻi at Mānoa researcher Stefan Moisyadi, who has been refining the concept for nearly a decade.
Oct 14, 2025
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Bioengineering breathes new life into failed cancer treatment
Many advanced cancers develop resistance to treatment and become highly aggressive, often leaving patients with limited treatment options. In some cancers, including lung, pancreatic and prostate tumors, a key driver of treatment ...
Oct 13, 2025
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Preclinical study identifies genetic misfire in lupus
Cedars-Sinai investigators have identified a "molecular switch" on a gene strongly associated with the autoimmune disease lupus, which appears to propel immune cells into overdrive, attacking and damaging healthy tissues ...
Oct 13, 2025
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How pollution and the microbiome interact with Tregs, the immune system regulators whose discovery won the Nobel Prize
A special group of immune cells known as regulatory T cells, or Tregs for short, became an overnight sensation when a trio of U.S. and Japanese scientists won the Nobel Prize in physiology or medicine on Oct. 6, 2025, for ...
Oct 13, 2025
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Blood cancer: Scientists reprogram cancer cell death to trigger immune system
The aim of immunotherapy strategies is to leverage cells in the patient's own immune system to destroy tumor cells. Using a preclinical model, scientists from the Institut Pasteur and Inserm successfully stimulated an effective ...
Oct 10, 2025
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