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Immunology news
Oncology & Cancer
Study identifies biomarker that could predict whether colon cancer patients benefit from chemotherapy
Many people with stage II or III colon cancer receive additional, or adjuvant, chemotherapy following surgery. However, clinical trials have shown that this treatment doesn't improve the chances of survival for every patient. ...
3 hours ago
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Neuroscience
Central nervous system-associated macrophages could modulate post-stroke immune responses
An ischemic stroke is a type of stroke that occurs when a blood clot in an artery, also known as thrombus, or the progressive narrowing of arteries, blocks the blood and oxygen flowing to the brain. This process can cause ...
23 hours ago
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Building bridges between cells for brain health: Research finds microglia rescue neurons through tunneling nanotubes
The brain contains many cell types, from the prominent neurons to the lesser-known microglia. The latter are integral to the brain's immune system and play a crucial role as the brain's cleanup crew. A recent study conducted ...
21 hours ago
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A new therapeutic target offers a promising pathway for multiple sclerosis treatment
Researchers from Kyushu University have identified a potential therapeutic target for the treatment of advanced multiple sclerosis (MS), a potentially disabling condition associated with the central nervous system.
23 hours ago
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Study uncovers key immune cells for combating aggressive Merkel cell carcinoma
Merkel cell carcinoma is a rare but highly aggressive form of skin cancer known for its rapid growth and tendency to metastasize. Despite the promise of immune checkpoint blockade therapy, which can boost the body's immune ...
19 hours ago
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Investigating the effect of alemtuzumab in allogeneic hematopoietic cell transplantation
Allogeneic hematopoietic cell transplantation (HCT) is a commonly used curative therapy for individuals with inborn errors of immunity (IEI). HCT involves introducing stem cells from a compatible donor with the aim of replacing ...
19 hours ago
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The human virome: Why viruses could be as important for good health as gut bacteria
We often hear about the importance of the human microbiome—the vast collection of bacteria and fungi that live on and inside us—when it comes to our health. But there's another, equally important part of this microbial ...
22 hours ago
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Prognostic and therapeutic insights into MIF, DDT, and CD74 in melanoma
A new research paper was published in Oncotarget entitled, "Prognostic and therapeutic insights into MIF, DDT, and CD74 in melanoma."
19 hours ago
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Electrical currents may make body's cancer-killing cells even better killers
Scientists have discovered that electrical currents may make natural killer (NK) cells—our very own cancer-killing immune cells—even better killers, which could have significant implications for treating some cancers.
Jul 25, 2024
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Immune cell transformation can influence stem cell transplant success in cancer patients
Researchers at UNC Lineberger Comprehensive Cancer Center and colleagues have determined that a specific type of immune cell—type II innate lymphoid cells (ILC2s)—can change its characteristics and functions after a cancer ...
Jul 25, 2024
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Organoids mimicking celiac disease show new link between gluten and intestinal damage
Small, laboratory-grown balls of cells made from the intestinal tissue of people with celiac disease have revealed a previously unknown molecular link between gluten exposure and intestinal damage, according to a study by ...
Jul 25, 2024
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Scientists identify key protein behind spread of shingles virus
Scientists at the University of Colorado Anschutz Medical Campus have discovered a new evasion strategy used by the varicella zoster virus, which causes chickenpox and shingles, that may allow it to affect tissues far from ...
Jul 25, 2024
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High levels of a specific antibody may contribute to acute coronary syndrome, investigators say
How a person's immune system responds to a protein called LL-37 may increase the risk of developing acute coronary syndrome, but the response may also serve as a potential target for future treatments. These findings come ...
Jul 25, 2024
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T cells and aging: Unraveling the complexities of lifespan
Aging significantly impacts the immune system, notably through the involution of the thymus, which reduces T cell production. This decline weakens immune responses, making older adults more susceptible to infections and diseases. ...
Jul 25, 2024
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Newly identified immune cell switch could control inflammation
Cornell researchers have identified a switch that regulates inflammation caused by an immune response, a finding that could one day help clinicians control inflammation-related conditions such as autoimmune, cardiovascular ...
Jul 24, 2024
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Clinical trial shows improved survival with blinatumomab in B-cell precursor leukemia subtype
A significant survival improvement finding for adults with newly diagnosed BCR::ABL1-negative B-cell precursor acute lymphoblastic leukemia appears in the New England Journal of Medicine. The practice-changing finding is ...
Jul 24, 2024
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Unique neutrophil type associated with Alzheimer's disease identified
Researchers have identified a unique type of neutrophil significantly associated with Alzheimer's disease (AD) pathology and mapped the transcriptome of neutrophils in the peripheral blood of AD mice. The study was published ...
Jul 24, 2024
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FDA-mandated CAR-T monitoring period could be halved, say researchers
In patients with diffuse large B-cell non-Hodgkin lymphoma (DLBCL), the two hallmark post-chimeric antigen receptor (CAR)-T therapy toxicities are extremely rare after two weeks, supporting a shorter, more flexible toxicity ...
Jul 24, 2024
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Blood test may guide use of multiple myeloma immunotherapy
A simple blood test that measures the number of lymphocytes, a type of white blood cell in the body, may predict whether people who have relapsed multiple myeloma are going to respond well to CAR-T immunotherapy, according ...
Jul 24, 2024
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Front-line drug for ulcerative colitis found to have additional mechanism of action that until now remained elusive
Monoclonal antibodies have become indispensable in medicine to combat cancers, infectious diseases and autoimmune disorders. But the mechanism of action of a major monoclonal antibody developed for ulcerative colitis has ...
