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Allergy and immunology news
Cellular neighborhoods inside tumors may predict which patients with melanoma benefit from combination immunotherapy
A new UCLA Health Jonsson Comprehensive Cancer Center study suggests that the way immune cells are organized inside melanoma tumors may help researchers better understand which patients will benefit from combination immunotherapy ...
4 hours ago
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B cells that fight infections may also boost muscle performance during exercise
B cells are white blood cells that form a core part of the body's adaptive immune system, enabling it to recognize specific infections, remember them, and mount a targeted response by producing antibodies. A recent study ...
22 hours ago
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Inside tumors, immune cells hide a split personality—and one side could quietly decide cancer's fate
Macrophages, key regulators of tissue health and immune defense, are among the most abundant immune cells in solid tumors. Their role in cancer has been difficult to define because even closely related macrophage populations ...
21 hours ago
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How immune cell networks drive liver disease
A type of rare T cell triggers a cascade of signals amplifying inflammation and ultimately leading to liver fibrosis, according to a new study from Julius Maximilian University of Würzburg published in Nature Communications. ...
20 hours ago
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Q&A: Why are women more likely to develop multiple sclerosis? A proteomics study provides clues
Knowing that women are diagnosed with multiple sclerosis (MS) at three times the rate of men, particularly during their 30s and 40s, scientists in the CU Anschutz lab of Kimberley Bruce, Ph.D., recently took that window of ...
16 hours ago
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HIV's earliest immune battle leaves blood traces that forecast powerful antibodies years later
Some people living with HIV develop antibodies capable of neutralizing many different strains of the virus. New research links this to immune responses that occur early in infection. The findings, published in PLOS Pathogens, ...
Apr 21, 2026
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Early myocarditis onset after immunotherapy may predict treatment-related fatality
Patients who developed myocarditis within the first month of receiving immune checkpoint inhibitor therapy were more likely to die of myocarditis, and myocarditis-specific fatality was more common in patients who experienced ...
Apr 21, 2026
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Cannabis may not be as anti-inflammatory as believed—research paints a more complex picture
Cannabis is no longer viewed solely as a recreational substance; it is increasingly recognized for its therapeutic potential. In many parts of the world, laws have evolved to include the use of cannabis for medical purposes. ...
Scientists map how HIV hijacks human cells—and how cells can fight back
The human immunodeficiency virus (HIV), which is the cause of AIDS, is a master of deception, using just nine genes to hijack the complex cellular machinery of the human body. Yet, even after decades of research on how the ...
Apr 20, 2026
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How to remove a metabolic tattoo: Scientists find protective mechanism in T cell purine pathways
While modern life includes many conveniences, humans are still incessantly exposed to a variety of metabolic stresses we have never experienced before. Our immune systems are constantly trying to protect us, and CD8⁺ T cells ...
Apr 20, 2026
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Protective 'switch' in most common blood cancer opens new doors for diagnosis and treatment
A new study published in The Journal of Immunology by researchers at the Josep Carreras Leukaemia Research Institute (IJC) has uncovered a crucial biological "off switch" in diffuse large B cell lymphoma (DLBCL), the most ...
Apr 20, 2026
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Robust flu protection may rely on B cells that are long-lived residents in the lungs
Deep in the lungs, resident memory B cells stand guard against influenza reinfection—but whether they remain there may depend on how strongly they are signaled through their own receptors. New research using an animal model ...
How mRNA cancer vaccines still destroy tumors when a key immune cell is missing
The advent of mRNA vaccines against SARS-CoV-2 in 2020 changed the course of the COVID-19 pandemic. Now, the Nobel Prize–winning technology is being adapted to fight cancer, with mRNA vaccines in clinical trials for melanoma, ...
Apr 18, 2026
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Cutting calories to slow aging—without compromising health
Restricting calorie intake in species such as mice, rhesus monkeys, and fruit flies has been shown to extend their lifespans. In some cases, these animals not only live longer, but are also free of disease. But when pushed ...
Apr 17, 2026
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First-in-human trial primes immune system to accept donor livers
UPMC and University of Pittsburgh clinician-scientists have weaned and kept multiple liver transplantation patients off of all immunosuppressant drugs for more than three years through a first-in-human clinical trial of a ...
Apr 17, 2026
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Older mice may offer new insight into cancer and aging
Cancer risk increases with age and is often more aggressive and difficult to treat in older adults. However, fewer than 10% of mouse studies use aged animals, with most relying on mice roughly equivalent to humans in their ...
Apr 17, 2026
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A hidden army of zombie immune cells may drive fatty liver disease, inflammation and aging
UCLA researchers have identified a rogue population of immune cells that quietly accumulates in aging tissues and in the livers of people with fatty liver disease. Clearing these cells, they found, dramatically reduced inflammation ...
Apr 16, 2026
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Programming the immune system to manufacture its own therapeutic proteins
An innovative gene-editing strategy could establish a new way for the body to manufacture therapeutic proteins—including certain kinds of highly potent antibodies that are naturally difficult to produce—by reprogramming the ...
Apr 16, 2026
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High-precision human immune aging clock identifies RUNX1 as key target for T cell senescence
The immune system acts as a critical sentinel of organismal aging, integrating the sensing of physiological states with the execution of defense and clearance functions. Immunosenescence not only reflects systemic functional ...
Apr 16, 2026
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Mitochondria keep key immune cells battle-ready by sustaining electron flow, study reveals
Researchers at the Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC) show that active mitochondria maintain dendritic cells, the immune system's sentinels, in a "ready-to-respond" state, linking cellular ...
Apr 15, 2026
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Immune system uses a conveyor belt-like process to edit defective antibodies, new research finds
The immune system's B cells create antibodies that can mount a response against just about anything—either destroying a pathogen or instructing the rest of the immune system to go after the offender. But what happens when ...
Apr 15, 2026
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How a misdirected DNA alarm could reshape treatment for rare rapid-aging diseases
The human immune system is finely tuned to detect and destroy viral threats. But this same defense system can misfire. When fragments of the body's own damaged DNA are mistaken for viral invaders, the result is a powerful, ...
Apr 15, 2026
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Silent B-cell mutations may build for years before thyroid autoimmunity appears
New research suggests that autoimmune diseases may be driven by DNA mutations in immune cells that remove the natural brakes on the immune system. It reveals a previously hidden role for somatic mutations—DNA changes acquired ...
Apr 14, 2026
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Taking a closer look at immune 'memory' could spur progress in the fight against lethal illnesses
The average human has about 1.8 trillion immune cells. These cells patrol the body for bacteria, viruses, cancers, and other threats. Vaccines enhance this security system by teaching our immune cells to target specific pathogens. ...
Apr 14, 2026
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High antibodies create disparities in donor search for blood and bone marrow transplants
People who have elevated levels of donor-specific anti-HLA antibodies (DSAs)—immune system proteins that can target and attack donor stem cells—wait an average of three additional months to receive blood or bone marrow transplants ...
Apr 14, 2026
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