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Immunology news
Immunology
Patient-driven discovery reveals potential target for autoimmune diseases
A medical mystery served as the genesis for a Yale-led study that has promising implications for treating a range of autoimmune diseases.
14 hours ago
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Oncology & Cancer
Study reveals dual role of protein in cancer treatment
Investigators at the UCLA Health Jonsson Comprehensive Cancer Center have uncovered new details about the role of a protein called interferon regulatory factor (IRF1) in cancer progression and treatment response, offering ...
14 hours ago
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Scientists develop potential stealth cancer therapy
Sneaking by cancer's defenses, by disguising tumor-fighting antibodies inside the molecules cancer uses to nourish tumor growth, is the basis of a novel therapy from Yale Cancer Center researchers at the Yale School of Medicine ...
14 hours ago
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Study uncovers unknown interaction between leukemic cells and immune cells
The protein STAT3 helps the immune system to recognize leukemic cells. This interaction, which is important for future immunotherapies, is now understood in detail thanks to a study at the Karl Landsteiner University of Health ...
11 hours ago
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Q&A: Patterns and prognostications in immune-related adverse events from immunotherapy treatment
Yevgeniy Semenov, MD, MA, a physician-investigator in the Mass General Department of Dermatology and an Assistant Professor of Dermatology at Harvard Medical School, and Guihong Wan, Ph.D., an Instructor of Dermatology at ...
10 hours ago
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Research suggests early life antibiotic increases asthma risk, providing clues to potential prevention of adult asthma
Early exposure to antibiotics can trigger long term susceptibility to asthma, according to new research from Monash University. Importantly, the research team isolated a molecule produced by gut bacteria that in the future ...
Jul 15, 2024
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Better together: Spatial arrangement of three immune cells is key to attacking tumors, study finds
There's a frustrating fact about today's immunotherapies for cancer. While sometimes they work beautifully—completely eliminating or greatly reducing cancer in particular patients—other times they don't work at all. It's ...
Jul 15, 2024
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Even mild SARS-CoV-2 infections have a long-term impact on the immune system, finds study
In a study recently published in Allergy, a MedUni Vienna research team shows that COVID-19 leads to considerable long-term changes in the immune system, even in mild cases. The findings could help to better understand the ...
Jul 15, 2024
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New study reveals immune protein's critical role in neuronal function and aging
A study conducted at the lab of Beth Stevens, Ph.D., at Boston Children's Hospital, has revealed that an immune protein impacts neuronal protein synthesis in the aging brain. Previous work from the Stevens lab had uncovered ...
Jul 15, 2024
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New biomarker shows potential to evaluate treatment response for metastatic colorectal cancer
Colorectal cancer is the second leading cause of cancer deaths worldwide and the third most diagnosed cancer, affecting over a million people annually. The problem worsens if the tumor is metastatic, meaning it moves from ...
Jul 15, 2024
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A seemingly paradoxical strategy: Varicella zoster virus spreads by enhancing an immune defense mechanism
Varicella zoster virus (VZV) can cause chickenpox, as well as shingles and severe complications. When one comes into contact with VZV for the first time, the virus enters the body through the airways, reaching the mucous ...
Jul 12, 2024
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Q&A: Researchers discuss cellular inflammation uncovered in rare neurodegenerative condition
Researchers at The Hospital for Sick Children (SickKids) have found that inflammation in an immune cell may be responsible in part for some severe symptoms in a group of rare genetic conditions called lysosomal storage diseases ...
Jul 12, 2024
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Study finds potential biomarkers for lung cancer immunotherapy resistance
Immunotherapy can be a highly effective treatment for non-small cell lung cancer (NSCLC), but some patients are resistant to the therapy or develop intolerable side effects.
Jul 12, 2024
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Targeted drug treatment leads tumor cells to imitate viral infection, researchers discover
A number of cancers, including certain brain and liver tumors, as well as myeloid leukemias, are driven by mutations in the enzyme isocitrate dehydrogenase 1, or IDH1. Drugs that block mutated IDH1 (mIDH1) have recently come ...
Jul 12, 2024
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Clarifying a synergistic effect between different types of antibodies in cancer treatment
The primary goal in cancer drug research is not merely to discover compounds that can destroy cancer cells, but to develop methods that specifically target and deliver these agents to cancer cells, sparing healthy ones.
Jul 12, 2024
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First guideline on immune monitoring in patients with a type of blood cancer
Researchers from King's College have led research that has resulted in the publication of first-of-their-kind guidelines that seek to standardize how clinicians measure the immune response of patients who have myelodysplastic ...
Jul 12, 2024
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First-of-its-kind clinical trial eliminates or shrinks melanoma tumors in 70% of patients
A clinical trial has shown that a new drug combination utilized before surgery completely eliminated or shrunk melanoma tumors in 70% of trial participants. The phase II clinical trial, NeoACTIVATE, enrolled patients with ...
Jul 11, 2024
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New immune cell therapy benefits lab models of ALS and shows positive results in an individual with the disease
Immune system dysregulation and elevated inflammation contribute to the development of the fatal neurodegenerative condition amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease.
Jul 11, 2024
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Immunotherapy approach shows potential in some people with metastatic solid tumors
Early findings from a small clinical trial provide evidence that a new cellular immunotherapy approach may be effective in treating metastatic solid tumors. In the trial, researchers from the National Institutes of Health ...
Jul 11, 2024
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Distinct T-cell signatures observed at different stages of type 1 diabetes development
A study conducted at the University of Eastern Finland found distinct signatures in CD8+ T cells in blood samples from children with newly diagnosed type 1 diabetes and in autoantibody-positive children who later developed ...
Jul 11, 2024
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