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Immunology news
Oncology & Cancer
Scientists unveil surprising human vs. mouse differences in a major cancer immunotherapy target
Since its discovery in the 1990s, programmed cell death protein 1 (PD-1) has been regarded as a leading target in cancer treatments. A checkpoint receptor that often resides on the surface of immune system cells, the PD-1 ...
Jan 3, 2025
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Novel class of anti-malaria antibodies could lead to next-generation interventions
A novel class of antibodies that binds to a previously untargeted portion of the malaria parasite could lead to new prevention methods, according to a study by researchers at the National Institutes of Health (NIH) published ...
Jan 3, 2025
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FDA approves subcutaneous opdivo qvantig for most solid tumor indications
The U.S. Food and Drug Administration has approved Opdivo Qvantig (nivolumab and hyaluronidase-nvhy) injection for subcutaneous use for most previously approved adult, solid tumor Opdivo (nivolumab) indications.
Jan 3, 2025
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Discovery of CAR-T 'memory cells' could boost cancer therapy
Researchers at the University of Colorado Anschutz Medical Campus have discovered that some CAR-T cells engineered to fight cancer and other conditions carry the memory of past encounters with bacteria, viruses and other ...
Jan 2, 2025
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Blood test can predict how long vaccine immunity will last, study shows
When children receive their second measles-mumps-rubella vaccine, around the time they start kindergarten, they gain protection against all three viruses for all or most of their lives. Yet the effectiveness of an influenza ...
Jan 2, 2025
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Microglia digest large Alzheimer's plaques by spitting enzymes at them, preclinical study finds
Immune cells in the brain called microglia can partially break down large amyloid plaques characteristic of Alzheimer's disease by latching on to them, forming a sort of external stomach and releasing digestive enzymes into ...
Jan 2, 2025
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T cells may offer some protection in an H5N1 'spillover' scenario
New research led by scientists at La Jolla Institute for Immunology (LJI) suggests that many people already have immune cells on standby to fight the H5N1 virus, also known as highly pathogenic avian influenza.
Jan 2, 2025
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Researchers find potential link between nuclear speckles patterns and cancer treatment outcomes
Fighting cancer can seem like a deadly game of chance. While some patients may respond well to certain treatments, others might not be as fortunate. Doctors and scientists have long struggled to explain why. Now, Cold Spring ...
Jan 2, 2025
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Targeting tristetraprolin in basophils: Researchers find promising therapeutic target for allergic inflammation
Inflammation is a crucial part of the body's defense mechanism, playing a key role in fighting infections and repairing tissue damage. Basophils, a type of immune cell that makes up less than 1% of white blood cells, have ...
Jan 2, 2025
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Clinical trial shows cancer-preventing topical immunotherapy trains immune system to fight precancers
A new study by investigators from Mass General Brigham uncovers how a novel immunotherapy prevents squamous cell carcinoma, with benefits lasting five years after treatment. This therapy is the first to activate specific ...
Jan 2, 2025
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Scientists link hematopoietic cell transplant deaths to beta-blocker use
Patients can die if they take certain previously prescribed beta-blockers during a hematopoietic cell transplant due to suppressed signals from nerves that promote bone marrow regeneration.
Dec 31, 2024
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Study reveals macrophages' misunderstood role in lung fibrosis
Researchers at National Jewish Health and colleagues have completed the first study comparing lung macrophages in multiple models of lung injury. The research indicates that macrophages previously described as "pro-fibrotic" ...
Dec 27, 2024
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Bidirectional association found between rheumatoid arthritis, COPD
There is a bidirectional association between rheumatoid arthritis (RA) and chronic obstructive pulmonary disease (COPD), according to a review published online Dec. 1 in Frontiers in Immunology.
Dec 27, 2024
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FDA approves Ryoncil for steroid-refractory acute graft-versus-host after allo-HSCT
The allogeneic bone marrow-derived mesenchymal stromal cell (MSC) therapy Ryoncil (remestemcel-L-rknd) has been approved for treatment for steroid-refractory acute graft-versus-host disease (SR-aGVHD) in pediatric patients ...
Dec 27, 2024
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What the color of your snot says about your immune health
Ever wondered why the color of your snot is different when you're sick? You're probably not the first person to ask this question.
Dec 25, 2024
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Engineered T cells could help patients overcome resistance to CAR T cell therapy
Physician-researchers with City of Hope have developed a way to add features to T cells to help them overcome mechanisms of chimeric antigen receptor (CAR) T cell therapy resistance. Their new system is outlined in a paper ...
Dec 24, 2024
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Unclogging the immune system: Scientists use immunotherapy to remove aging cell buildup
Whenever a sink overflows, the flooding is usually caused by a blockage that has built up in the drains. Similarly, as we age, our bodies are flooded by aging, or senescent cells, which have stopped dividing but, instead ...
Dec 23, 2024
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Previously unknown protein interactions may lead to better HIV treatments
The human immune deficiency virus (HIV) first entered public consciousness in the early 1980s, after cases of unfamiliar and deadly illnesses began to overwhelm medical centers across North America.
Dec 23, 2024
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Microscopic cell changes linked to cancer's rapid growth in stiff tissues
In 2022 alone, over 20 million people were diagnosed with cancer, and nearly 10 million died from the disease, according to the World Health Organization. While the reaches of cancer are massive, the answer to more effective ...
Dec 21, 2024
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Experimental drug that summons 'warriors of the immune system' shows early promise against non-Hodgkin lymphoma
An investigational therapy is demonstrating preclinical promise against non-Hodgkin lymphoma by boosting natural killer cells and efficiently annihilating the malignancy without toxicity to the patient, a team of cancer biologists ...
Loosening chimeric antigen receptor's grip on T-regulatory cells improves function, researchers find
A new paper from MUSC Hollings Cancer Center researchers is helping to reveal the "rules" for engineering chimeric antigen receptor (CAR) Tregs.
Dec 20, 2024
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Molecular and cellular level research shows a sharp sex divide for long COVID—women are more vulnerable
Scientists have identified "immune pathways" during acute coronavirus infection that are associated with the development of long COVID, and while some pathways are the same for men and women, others differ dramatically along ...
How a newly examined gut microbe drives the gut-lung axis
A team led by University of Toronto researchers has discovered a new communication pathway between the gut and lung.
Dec 19, 2024
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Scientists design workaround that improves response to flu vaccine
Stanford Medicine scientists have designed a way to make our seasonal influenza vaccinations more broadly effective and possibly to protect us from new flu variants with pandemic potential. In a study published in Science, ...
Dec 19, 2024
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