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Immunology news
Oncology & Cancer
How a leukemia hijacks the genes needed by blood stem cells
As a child, Lynn Aureli didn't know that a particular genetic change contributed to her acute myeloid leukemia (AML)—an alteration that eventually would help explain the cancer's lack of response to chemotherapy. Nor was ...
Jan 27, 2023
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Immunology
COVID booster vaccines: How a third dose may help vulnerable people 'level up' their immunity
COVID vaccines call our immune systems to action, generating antibodies which fight against any contact we have with the virus. Antibodies help to reduce the effects of an infection or even prevent it altogether. Scientists ...
Jan 27, 2023
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Children's immune response to COVID is fast but doesn't last, finds study
Children have largely avoided severe COVID-19 symptoms because they have a strong initial 'innate' immune reaction that quickly defeats the virus. And now, researchers led by scientists at the Garvan Institute of Medical ...
Jan 26, 2023
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Keys to making immunotherapy work against pancreatic cancer found in tumor microenvironment
A new study that analyzed the tumor microenvironment of pancreatic cancer revealed the cause of tumor cell resistance to immunotherapy and resulted in new treatment strategies.
Jan 26, 2023
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An unexpected T cell exhaustion factor driving cancer immunotherapy resistance
A research team from the LKS Faculty of Medicine, the University of Hong Kong (HKUMed) has identified an unexpected driver of cancer immunotherapy resistance: the harmful effect of chronic Type I Interferon signaling on tumor-killing ...
Jan 26, 2023
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'Hard to lose' mutations in tumors may predict response to immunotherapy
Cancer experts have tried, sometimes unsuccessfully, to use the total number of mutations in a tumor, called the tumor mutation burden (TMB), to predict a patient's response to immunotherapy. Now, investigators at the Johns ...
Jan 26, 2023
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Antibodies against coronavirus 'coldspots' discovered
The coronavirus keeps evolving, and in so doing it evades our immune defenses. But does the entire coronavirus evolve, or do some portions remain unchanged?
Jan 26, 2023
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Intraventricular immunovirotherapy: A translational step forward
A new research perspective titled "Intraventricular immunovirotherapy; a translational step forward" has been published in Oncotarget.
Jan 26, 2023
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Even bivalent updated COVID-19 boosters struggle to prevent omicron subvariant transmission
By almost any measure, the vaccination campaign against SARS-CoV-2, the virus that causes COVID-19, has been a global success.
Jan 26, 2023
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Expert analysis refutes claims that humans are colonized by bacteria before birth
Scientific claims that babies harbor live bacteria while still in the womb are inaccurate, and may have impeded research progress, according to University College Cork (UCC) researchers at APC Microbiome Ireland, a world-leading ...
Jan 25, 2023
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Researchers find immune response to COVID strengthens over time
Immunity from COVID-19 appears to gather strength with more time between vaccination and infection, a new laboratory study from researchers at Oregon Health & Science University suggests. The findings carry implications for ...
Jan 25, 2023
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Bacterium may decrease effectiveness of immunotherapy
Helicobacter pylori is a bacterium that colonizes the stomach lining and is found in more than half of the global population, making it one of the most widespread bacterial infections in the world.
Jan 25, 2023
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Tumor microbiome linked to immunotherapy success in sarcoma patients
In a new study, UC Davis Comprehensive Cancer Center researchers have uncovered a link between a patient's microbiome and their immune system that can potentially be used to improve the treatment of soft tissue sarcoma. This ...
Jan 25, 2023
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Uptake low for COVID-19 vaccine boosters in immunocompromised adults
For immunocompromised adults, adherence to U.S. Centers for Disease Control and Prevention mRNA monovalent COVID-19 booster dose recommendations is low, according to a study published online Jan. 20 in JAMA Network Open.
Jan 25, 2023
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Probing the genetics of autoimmune disease
There are many forms of autoimmune disease, but by definition they all have one thing in common—they arise when the body's immunological defenses go awry and attack our cells or trigger biochemical changes that lead to ...
Jan 25, 2023
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The time is now to curb spring allergies
Send yourself some love this Valentine's Day by setting a reminder to start taking your spring allergy medications.
Jan 25, 2023
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Immune signaling component FBXC-58 found to mediate dietary restriction effects on healthy aging in C. elegans
Dietary restriction (DR) is a highly effective and reproducible intervention that prolongs longevity in many organisms. The molecular mechanism of action of DR is tightly connected with the immune system; however, the detailed ...
Jan 25, 2023
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Propionic acid protects nerve cells and helps them regenerate, shows study
Some autoimmune diseases attack the nerves in the arms and legs. Bochum-based researchers are pursuing a new approach to counteracting this damage.
Jan 24, 2023
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Study suggests a way to re-energize tired T cells when treating cancer, viral infections
A new study by researchers at The Ohio State University Comprehensive Cancer Center—Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC—James) suggests a way to re-energize critical killer ...
Jan 24, 2023
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To rev-up CAR T-cell therapy, inhibit the SUSD2 membrane protein, study suggests
Inhibiting a particular protein in cancer-killing immune cells might improve the long-term effectiveness of CAR T-cell and other immune checkpoint therapies, according to a new study by researchers at The Ohio State University ...
Jan 24, 2023
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