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Immunology news
Immunology
Organ-specific inflammation masquerades as relapse in CAR T-cell remission
Researchers at Friedrich-Alexander-Universität Erlangen-Nürnberg have identified a previously undocumented, organ-specific toxicity linked to CD19-targeted CAR T-cell therapy in autoimmune disease. The syndrome, termed ...
19 hours ago
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Single-cell RNA sequencing of bone metastases from multiple cancer types reveals three distinct immune archetypes
Bone is a common site for metastasis of solid cancers, but histological and molecular features of bone metastases are not well understood. In a new study published in Cell Genomics, researchers at Baylor College of Medicine ...
18 hours ago
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Turning up the heat helps animals fight germs—how Mother Nature's cure offers humans a lesson on fever
Why do people get fevers when we get sick?
19 hours ago
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COVID virus 'reprograms' infection fighters into immune system suppressors, study shows
A study by researchers from Johns Hopkins Medicine, the Johns Hopkins Bloomberg School of Public Health and The Johns Hopkins University Whiting School of Engineering finds that neutrophils—the most abundant type of white ...
May 22, 2025
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Discovering new ways to recharge T-cells fighting cancer
A pair of recent studies from the laboratory of Bin Zhang, MD, Ph.D., the Johanna Dobe Professor of Cancer Immunology, have uncovered new details about critical biological processes that may help improve cancer treatments.
May 22, 2025
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Viral mechanism uses mitochondrial remodeling to block immune response, presenting a new drug target
Researchers at The Wistar Institute have identified a previously unknown mechanism by which viruses can reprogram mitochondrial structure to silence immune responses and ensure successful viral reproduction.
May 22, 2025
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Wastewater helps monitor cancer-causing HPV
Scientists in Uruguay have found genotypes of the human papillomavirus (HPV) linked to cervical cancer in urban wastewater, saying it could help inform disease prevention efforts.
May 22, 2025
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Common antidepressants could help the immune system fight cancer
A widely used antidepressant drug could help the immune system fight cancer, according to a new UCLA research study.
May 21, 2025
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Study uncovers link between pathogen adaptation and autoimmune diseases in Han Chinese
A new study led by Profs. Xu Tao and He Shunmin from the Institute of Biophysics of the Chinese Academy of Sciences has revealed how human leukocyte antigen (HLA) genes, central to the immune system, influence both pathogen ...
May 21, 2025
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Stem cell transplant offers potentially curative therapy in pediatric patients with monogenic inflammatory bowel disease
A collaborative team of researchers from Children's Hospital of Philadelphia (CHOP) found that hematopoietic stem cell transplantation (HSCT) is a highly effective method for treating patients with monogenic inflammatory ...
May 21, 2025
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T cell cytokines found to influence tumor-immune interactions in metastases
Memorial Sloan Kettering Cancer Center investigators report that T cell interferon-γ (IFNγ) orchestrates a dendritic-cell–natural-killer-cell circuit that suppresses leptomeningeal metastases in mouse models.
Scientists uncover key clues to how a viral infection can lead to arthritis-like disease
Chikungunya virus (CHIKV) is a mosquito-borne pathogen that has been identified in more than 110 countries around the world. The virus typically causes flu-like symptoms, but it can also trigger chronic, severe joint pain ...
May 20, 2025
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Why are patients with mitochondrial disease more susceptible to infections? New study finds the answer
Patients with rare mitochondrial diseases already face a host of serious health issues, from muscle weakness to neurological problems and heart conditions. But one of their most life-threatening challenges has remained a ...
May 20, 2025
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Hidden diversity in fibroblasts may hold key to tissue repair
Fibroblasts play a central role in maintaining healthy tissue structures, as well as in the development and progression of diseases. For a long time, these specialized connective tissue cells were thought to represent a single, ...
May 20, 2025
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Aging reduces CAR-T cell effectiveness by impairing metabolism, study shows
As people age, their immune systems become less efficient, posing a challenge for cancer therapies that rely on harnessing immune cells.
May 20, 2025
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Streamlined technique rapidly measures cells' density, reflecting health and developmental state
Measuring the density of a cell can reveal a great deal about the cell's state. As cells proliferate, differentiate, or undergo cell death, they may gain or lose water and other molecules, which is revealed by changes in ...
May 20, 2025
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'Obesity paradox' extends to cancer treatment, study finds
It's well-known that obesity is a risk factor for cardiovascular disease. But some research suggests that while people who are obese are more likely to develop cardiovascular problems, they're also less likely to die from ...
May 20, 2025
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Study advances cancer precision therapies by identifying patients who benefit from bexmarilimab treatment
Researchers at the University of Turku, Finland, have taken a step towards more personalized and effective cancer treatments. A new study has identified the conditions under which the antibody drug bexmarilimab can activate ...
May 20, 2025
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CAR-T cell therapy is revolutionizing cancer treatment. Here's how it works
Personalized medicine is already a reality in clinical practice, and CAR-T cell therapy is one of its most promising tools. This innovative approach, which involves genetically modifying the cells of the immune system, is ...
May 20, 2025
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Patient with advanced skin cancer in remission for more than a year following clinical trial of WTX-124
A common and unsightly skin cancer that can turn deadly has been undetectable for more than a year in a patient treated with a new targeted immune-therapy in a clinical trial at HonorHealth Research Institute.
May 20, 2025
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Positive proof-of-concept experiments may lead to the world's first treatment for celiac disease
An investigational treatment for celiac disease effectively controls the condition—at least in an animal model—in a first-of-its-kind therapeutic for a condition that affects approximately 70 million people worldwide.
Immune cells trained to hunt tumors after scientists plant synthetic 'flags' on cancer
Biomedical engineers at Georgia Tech created a treatment that could one day unlock a universal strategy for treating some of the hardest-to-treat cancers—like those in the brain, breast, and colon—by teaching the immune ...
May 19, 2025
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How the Epstein-Barr virus promotes its spread within the body
Many people are infected with the Epstein-Barr virus (EBV), and most are unaware of it. However, EBV can sometimes cause cancer, and this pathogen also appears to play an important role in multiple sclerosis and other autoimmune ...
May 19, 2025
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RNA binding proteins found essential for regulatory T cell function and immune homeostasis
Immunologists from the Institute have been the first to uncover a role for a family of RNA binding proteins in the function of regulatory T cells in the immune system. As their name suggests, regulatory T cells (Tregs) play ...
May 19, 2025
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