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Genetics news

Oncology & Cancer

Digital twin research finds colon cancer cells can be reverted to normal cells

Despite the development of numerous cancer treatment technologies, the common goal of current cancer therapies is to eliminate cancer cells. This approach, however, faces fundamental limitations, including cancer cells developing ...

Genetics

Gene editing tool reduces Alzheimer's plaque precursor in mice

A new gene editing tool that helps cellular machinery skip parts of genes responsible for diseases has been applied to reduce the formation of amyloid-beta plaque precursors in a mouse model of Alzheimer's disease, researchers ...

Genetics

New findings expand genetic knowledge of autism underpinnings

Hundreds of novel genetic variants across an ancestrally diverse cohort of 195 families, including 222 people with autism spectrum disorder (ASD), have been identified by researchers at UT Southwestern Medical Center, expanding ...

Oncology & Cancer

Overcoming glioblastoma resistance to chemotherapy

In spite of intensive research, glioblastoma remains one of the most lethal types of brain cancer. Temozolomide (TMZ) is used as the front-line medicine in its treatment.

Genetics

Large-scale study links dyslexia genetics to brain structure

Dyslexia is a common learning difficulty in which genes often play a role. How do genes associated with dyslexia relate to brain structure in the general population? In a large-scale study published in Science Advances, a ...

Genetics

New gene therapy could alleviate chronic pain, researchers find

Pain is meant to be a defense mechanism. It creates a strong sensation to get us to respond to a stimulus and prevent ourselves from further harm. But, sometimes injuries, nerve damage, or infections can cause long-lasting, ...

Genetics

Genetic testing moving into the mainstream, study finds

Genetic testing, which has expanded in recent years with advances in technology and the development of consumer products, is on a path to widespread acceptance in the U.S., researchers at UT Southwestern Medical Center found. ...

Genetics

Researchers discover molecular events leading to Rett syndrome

Researchers at Baylor College of Medicine, Jan and Dan Duncan Neurological Research Institute (Duncan NRI) at Texas Children's Hospital and collaborating institutions have gained new insights into the molecular changes leading ...

Genetics

Collaborative seeks to change children's lives through genetics

A 14-year-old girl was having back pain after a car accident and visited an orthopedic clinic at Boston Children's Hospital. In the course of her care, she joined the Children's Rare Disease Collaborative (CRDC), a hospital-wide ...

Genetics

Mini-brains reveal how mitochondrial mutations affect brain cells

Researchers at the University of Bergen have used advanced stem cell technology to develop mini-brains, also called brain organoids, that can mimic disease processes caused by mitochondrial failure. This could open new avenues ...

Oncology & Cancer

High-altitude gene variant linked to better blood cancer prognosis

Two researchers from Huntsman Cancer Institute at the University of Utah (the U) have discovered a gene variant found in high-altitude Andean populations that they believe could be a new biomarker for predicting the severity ...

Genetics

New drug strategy targets rare immune disorders' genetic roots

Several rare immune disorders are caused by mutations in the patient's DNA. In a new study published in the Journal of Clinical Immunology, the University of Surrey and its collaborators found that targeting the mutated pathways ...

Oncology & Cancer

Study links smoking to genetic mutations in blood cancer

Smokers with myelodysplastic syndromes (MDS) or a precursor condition had elevated levels of genetic mutations linked to the disease, a new study shows. The study also found that heavier smokers accumulated more mutations, ...