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Genetics news

Medical research

Researchers develop 'dimmer switch' to help control gene therapy

In a major advancement in the field of gene therapy for rare and devastating diseases, researchers at Children's Hospital of Philadelphia (CHOP) have developed a "dimmer switch" system that can control levels of proteins ...

Genetics

Gene associated with autism linked to itch response

A pilot study from North Carolina State University has found that a gene associated with autism spectrum disorder (ASD) and pain hypersensitivity may actually decrease itch response. Atopic dermatitis and pain hypersensitivity ...

Genetics

Three genes determine heart cell growth

Heart disease has long been the leading cause of death globally. One reason is that the heart has poor regenerative properties, causing damage to accumulate. Scientists have speculated that understanding how the heart grows ...

Oncology & Cancer

The potential role of 'junk DNA' sequence in aging, cancer

The human body is essentially made up of trillions of living cells. It ages as its cells age, which happens when those cells eventually stop replicating and dividing. Scientists have long known that genes influence how cells ...

Genetics

Links between genetic risk, glaucoma prevalence examined

(HealthDay)—Polygenic variants are associated with comparable risk for developing open-angle glaucoma as that associated with the most common single-gene pathogenic variant, according to a study published online July 15 ...

Medical research

Gene expression mechanism may have immunity, cancer implications

Alternative polyadenylation (APA) is an RNA processing mechanism that regulates gene expression by generating different ends on RNA transcripts of the same gene. Though it affects more than half of human genes, the significance ...

Medications

Treatment for rare Bachmann-Bupp syndrome developed in 16 months

Diagnosing a rare medical condition is difficult. Identifying a treatment for it can take years of trial and error. In a serendipitous intersection of research expertise, an ill patient in this case a child and innovative ...

Genetics

When mad AIOLOS drags IKAROS down: A novel pathogenic mechanism

Primary immunodeficiencies, such as severe combined immunodeficiency disease (SCID), occur when the immune system does not work properly, leading to increased susceptibility to various infections, autoimmunity, and cancers. ...

Genetics

New genetic knowledge about cluster headache

Researchers at Karolinska Institutet, together with British colleagues, have conducted the largest study to date in search of genetic markers about cluster headache. In the long term, it can hopefully pave the way for more ...

Medical research

How cells keep gene silencing in check

Long considered 'junk," non-coding RNAs have emerged as important regulators of diverse cellular processes, including the silencing of genes. Working in yeast, researchers from the Bühler group have identified more than ...

Genetics

UN calls for global database of human gene editing research

The World Health Organization issued new recommendations Monday on human genome editing, calling for a global registry to track "any form of genetic manipulation" and proposing a whistle-blowing mechanism to raise concerns ...

Medical research

Remarkable new insights into the pathology of Usher syndrome

Human Usher syndrome (USH) is the most common form of hereditary deaf-blindness. Sufferers can be deaf from birth, suffer from balance disorders, and eventually lose their eyesight as the disease progresses. For some 25 years ...

Genetics

Our genes shape our gut bacteria, new research shows

Our gut microbiome—the ever-changing "rainforest" of bacteria living in our intestines—is primarily affected by our lifestyle, including what we eat or the medications we take, most studies show.

Genetics

Large genomic analysis highlights COVID-19 risk factors

In March of 2020, thousands of scientists around the world united to answer a pressing and complex question: what genetic factors influence why some COVID-19 patients develop severe, life-threatening disease requiring hospitalization, ...

Oncology & Cancer

Families SHARE, an educational genomics workbook

Researchers at the National Human Genome Research Institute (NHGRI), part of the National Institutes of Health (NIH), have developed the Families Sharing Health Assessment and Risk Evaluation (SHARE) workbook, which helps ...