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Clinical genetics news
Study of 3 million Swedes links women's suicide risk to female relatives' attempts
A woman's suicide risk may be influenced by the suicidal intention of her female first degree relatives, with sex-specific effects of a shared familial environment and possibly other social factors having a key role, finds ...
1 hour ago
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Study identifies gene linked to chemotherapy resistance in prostate cancer
A gene called FOXJ1 may drive resistance to taxane chemotherapy during treatment for advanced prostate cancer, according to a new study led by investigators at Weill Cornell Medicine and Beth Israel Deaconess Medical Center. ...
3 hours ago
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Long-read genome sequencing uncovers new autism gene variants
Researchers at the University of California San Diego have identified new genetic variants associated with autism spectrum disorder (ASD) by using long-read whole genome sequencing (LR-WGS), an emerging approach that reads ...
Mar 9, 2026
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Why lungs age unevenly: Vulnerable cells may guide new therapies
Aging is associated with increased risk for nearly every lung disease, including acute conditions like pneumonia and chronic diseases like chronic obstructive pulmonary disease, idiopathic pulmonary fibrosis, and lung cancer. ...
Mar 9, 2026
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'Asian flush' mutation may trigger ferroptosis during heart attacks, study reveals
About 40% of East Asians suffer from alcohol intolerance, known as "Asian Flush Syndrome," caused by an ALDH2 genetic mutation. Beyond facial flushing, this mutation carries serious cardiovascular risks. Carriers experience ...
Mar 9, 2026
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Study finds shared genetic roots of multiple sclerosis across diverse ancestries
A new study published in Neurology, led by Queen Mary University of London, has revealed that people of South Asian, African and European ancestry share many of the same genetic risk factors for multiple sclerosis (MS).
Mar 9, 2026
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FOXJ3 gene emerges as a potential driver of drug-resistant focal epilepsy
Researchers have discovered that mutations in the FOXJ3 gene act as a "master switch" failure, disrupting how the brain builds its layers and leading to FCD, a primary cause of drug-resistant epilepsy. The study, published ...
Mar 9, 2026
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Study reveals worrying extent of imprecise gene and gene mutation naming
A systematic review of 52 scientific papers submitted to a world-leading clinical genetics journal from multiple scientists over a two-year period reveals that not a single one named critical gene mutations (correctly termed ...
Mar 9, 2026
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Preventing breast cancer resistance to CDK4/6 inhibitors using genomic findings
Researchers at Memorial Sloan Kettering Cancer Center (MSK) have made an important discovery about how genetic mutations in breast cancer patients can interact and drive resistance to certain drugs called CDK4/6 inhibitors. ...
Mar 8, 2026
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Japan approves stem-cell treatment for Parkinson's in world first
Japan has approved ground-breaking stem-cell treatments for Parkinson's and severe heart failure, one of the manufacturers and media reports said Friday, with the therapies expected to reach patients within months.
Mar 6, 2026
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Consent and its discontents: UK Biobank projects may breach trust of thousands of participants
UK Biobank is a major biomedical database and research resource, holding the genetic, health, and lifestyle information of half a million adult volunteers. Its datasets are accessible to approved researchers from academic, ...
Mar 5, 2026
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mRNA therapy restores fertility in genetically infertile mice
Researchers have found that targeted delivery of messenger RNA (mRNA) can restore sperm production and fertility in genetically infertile male mice. The findings, published in Stem Cell Reports, demonstrate that transient ...
Mar 5, 2026
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Life-changing drug identified for children with rare epilepsy
A new experimental treatment for children with a hard-to-treat form of epilepsy is safe and can reduce seizures dramatically, helping them lead much healthier and happier lives, according to the findings of a UCL (University ...
Mar 4, 2026
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A promising potential therapeutic strategy for Rett syndrome
A team of researchers at Baylor College of Medicine and the Duncan Neurological Research Institute (Duncan NRI) at Texas Children's Hospital reports in Science Translational Medicine a potential new approach to treat Rett ...
Mar 4, 2026
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Key DNA changes in the brains of people with Alzheimer's disease identified
In a study published in Nature Communications, Mayo Clinic researchers have identified specific DNA-level changes in the brains of people with Alzheimer's disease (AD). Using advanced biological analysis, the team mapped ...
Mar 3, 2026
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New knowledge on heritability paves the way for better treatment of chronic inflammatory bowel disease
Approximately 60,000 Danes live with chronic inflammatory bowel disease. Some experience limited discomfort, while others go through a debilitating disease course involving surgery and a stoma. Add to this the fear of leaving ...
Mar 2, 2026
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Tracking mysteries of loss of Y chromosome, cancer
The Y chromosome is among the smallest in the human body and carries the fewest genes. Researchers are paying renewed attention to its role in cancer—specifically, what happens when it vanishes.
Mar 2, 2026
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What is a 'cancer gene'? How genetic mutations lead to cancer
An estimated 170,000 Australians were diagnosed with cancer in 2025. Many people know the causes of cancer are partly genetic. But how do your genes, which contribute so much of what makes you you, change what they do and ...
Mar 1, 2026
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Jumping 'DNA parasites' linked to early stages of tumor formation
A study published in the journal Science reveals how jumping fragments of human DNA, a type of genetic parasite, destabilize the cancer genome. Unstable genomes are a fertile playground for cancer evolution, giving malignant ...
Feb 26, 2026
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Study reveals genetic balancing act between autoimmunity and cancer risk
An autoimmune disorder that affects the thyroid gland, called autoimmune hypothyroidism (AIHT), is the most common autoimmune disease, yet it remains largely understudied. New research from scientists at Broad Institute, ...
Feb 26, 2026
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Cigarette smoke accelerates eye aging via epigenetic changes, study finds
Through a series of experiments supported by the National Institutes of Health, Johns Hopkins Medicine (JHM) researchers say they have advanced understanding of how smoking damages the eye and contributes to the development ...
Feb 26, 2026
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The developing Down syndrome brain: Scientists create most detailed molecular map to date
Scientists from Duke-NUS Medical School, working with collaborators at Imperial College London and partners in Europe and the United States, have uncovered new insights into how an additional copy of chromosome 21 alters ...
Feb 26, 2026
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Chondrocytes' behavior reveals novel targets for bone growth disorders
Achondroplasia, also known as short-limb dwarfism, is associated with neurological symptoms and complications due to narrowing of the skeletal structures surrounding the spinal cord. Despite achondroplasia being the most ...
Feb 26, 2026
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Is a baby's heart defect hereditary? A NOTCH1 methylation test may clarify
One to two out of every 100 newborn babies are born with a Congenital Heart Defect (CHD), yet the exact cause remains unclear. Human geneticists at the University Medicine Oldenburg (Germany) have now presented a new method ...
Feb 26, 2026
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Study identifies erythropoietin as a potential active ingredient in Primrose syndrome
A research team from Mannheim, Göttingen, Varna, and Princeton has discovered in animal studies with mice that the growth factor recombinant human erythropoietin (rhEPO) can significantly improve cognitive and social problems ...
Feb 26, 2026
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