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Genetics news
Genetics
Scientists find cause of rare devastating, autoimmune disease in Puerto Ricans—but also find potential treatment
A rare autoimmune condition with a tongue-twister of a name may impact people of Puerto Rican heritage through a newly discovered genetic pathway, a discovery that may ultimately guide genetic counseling and treatment, scientists ...
Nov 29, 2024
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Genetics
Gene-screening method identifies cause of heart cell damage from chemotherapy
Using a gene-screening method they created, Stanford Medicine researchers may have discovered why an effective chemotherapy damages heart cells—and they have identified a drug that could keep the heart cells beating.
Nov 29, 2024
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Genetic study discovers mechanisms that make Ewing sarcoma more aggressive
Ewing sarcoma is a tumor of the bones and soft tissues that occurs in children and young people. Like all childhood cancers, it is rare—nine to 10 cases per million inhabitants per year—but it is very aggressive: 25% ...
Nov 29, 2024
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Researchers identify six-gene pattern to predict drug success in multiple myeloma patients
Researchers at the Icahn School of Medicine at Mount Sinai have discovered how genetics can affect the success of venetoclax, a treatment for multiple myeloma, a rare type of blood cancer. Their study, "Predictors of Response ...
Nov 29, 2024
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FDA approves Kebilidi for aromatic L-amino acid decarboxylase deficiency
The U.S. Food and Drug Administration has approved PTC Therapeutics' Kebilidi (eladocagene exuparvovec-tneq) for the treatment of adult and pediatric patients with aromatic L-amino acid decarboxylase (AADC) deficiency.
Nov 27, 2024
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A universal gene therapy for Diamond-Blackfan anemia is poised for clinical trials
Efforts to develop a gene therapy for Diamond-Blackfan anemia (DBA)—a rare, life-threatening disorder in which bone marrow cannot make mature, functioning red blood cells—have been hampered by the fact that at least 30 ...
Nov 26, 2024
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Spatial genomics approach shows cancers grow uniformly, challenging the idea of 'two-speed' entities
Researchers at the University of Cologne and the Center for Genomic Regulation (CRG) in Barcelona have discovered that cancer grows uniformly throughout its mass, rather than at the outer edges. The work, published in the ...
Nov 26, 2024
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Scientists discover new details of gene regulation that control cell identity
Genes make up the blueprints and outline the process of building every living organism. To ensure that the right genes are activated in the right cells, and in the right amounts at the right time, genes are constantly being ...
Nov 26, 2024
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Study reveals genetic drivers of early onset type 2 diabetes in South Asians
A genetic predisposition to having lower insulin production and less healthy fat distribution are major causes of early-onset type 2 diabetes in British Asian people. According to new research from Queen Mary University of ...
Nov 26, 2024
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Bringing genomics into public policy requires greater awareness, professional training and investment, experts say
The lack of knowledge about the benefits of human genomics for public and individual health, together with the scarcity of qualified professionals and low investment, are among the challenges that countries need to overcome ...
Nov 26, 2024
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Researchers identify potential genes linking depression to menstrual pain
Women are twice as likely as men to suffer from depression and often experience more severe physical symptoms. This gender difference is particularly evident during reproductive years and dramatically impacts the lives of ...
Nov 26, 2024
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New thesis on diagnostic methods for genetic immune deficiencies offers hope for better treatments
Laura Covill from the Hematology Unit/HERM, at the Department of Medicine, Huddinge (MedH), is defending her thesis titled "Genetic and epigenetic diagnostics of viral susceptibility and inborn errors of immunity," on 29 ...
Nov 26, 2024
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Chromosomal chaos promotes therapy resistance in leukemia cells and opens up new treatment approaches
Chromosomal instability plays a crucial role in the progression of cancer: it shapes the properties of tumor cells and drives the development of therapy resistance. Scientists from the German Cancer Research Center (DKFZ), ...
Nov 25, 2024
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Cells use backup mechanism to recognize potential invaders when usual RNA editing process fails, study finds
Our cells need to be able to recognize potential invaders as a threat, the key function of the body's innate immune system. Sometimes this process fails, causing the body to react to its own cells, leading to autoinflammatory ...
Nov 25, 2024
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Genetic clues explain why children develop rare post-COVID condition
Scientists have uncovered genetic variants that help to explain why some children with mild COVID-19 go on to develop a severe inflammatory condition weeks after their infection.
Nov 25, 2024
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Researchers identify gene signature for high-risk form of T-cell acute lymphoblastic leukemia
Researchers from Children's Hospital of Philadelphia (CHOP) have discovered the underlying biology that identifies a subset of patients with acute lymphoblastic leukemia who have a higher risk version of the disease and are ...
Nov 25, 2024
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Innovative approach maps gene activity in the living human brain
A new method to profile gene activity in the living human brain has been developed by researchers at FutureNeuro, the Research Ireland Center for Translational Brain Science and RCSI University of Medicine and Health Sciences, ...
Nov 25, 2024
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Researchers identify a novel genetic cause of mitochondrial DNA depletion syndrome
Mitochondrial DNA depletion syndrome (MTDPS) is a rare genetic disorder characterized by a marked decrease in mitochondrial DNA (mtDNA). This condition can cause symptoms including muscle weakness, fatigue, and neurological ...
Nov 25, 2024
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RNA editing is the next frontier in gene therapy—here's what you need to know
The United States Food and Drug Administration has just approved the first-ever clinical trial that uses CRISPR-Cas13 RNA editing. Its aim is to treat an eye disease called wet age-related macular degeneration that causes ...
Nov 23, 2024
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Scientists identify key mechanism in development of skin cancer
LMU researchers have discovered how the interplay between a key protein and an endolysosomal ion channel promotes tumor development in skin cancer.
Nov 22, 2024
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How ovarian cancer cells adapt while moving across tissues
The spread of tumor from the primary cancer site to distant organs, called metastasis, has puzzled scientists for many years—they are only now beginning to pinpoint triggers and mechanisms that drive this process.
Nov 22, 2024
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Using principles from pest management, researchers aim to extend survival rate, quality of life for cancer patients
Just as crop-devouring insects evolve to resist pesticides, cancer cells can increase their lethality by developing resistance to treatment. In fact, most deaths from cancer are caused by the evolution of therapeutic resistance.
Nov 22, 2024
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Scientists discover 'toolkit' to fix DNA breaks associated with aging, cancer and motor neuron disease
A new "toolkit" to repair damaged DNA that can lead to aging, cancer and motor neuron disease (MND) has been discovered by scientists at the Universities of Sheffield and Oxford.
Nov 21, 2024
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Presence of white spots on MRI brain scans linked to genetic risk of dementia in older adults
They show up as bright white spots when you get a brain MRI: lesions called white matter hyperintensities, or WMH. And their presence suggests something may be wrong with your brain's white matter—there could be structural ...
Nov 21, 2024
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Brain tumor research identifies source of glioma's deadly transformation
Gliomas are the most common brain tumors, and many start off growing slowly as "low-grade" tumors before inevitably becoming aggressive, lethal, and "high grade." New research offers an explanation for this deadly transformation.
Nov 21, 2024
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