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Genetics news
Genetics
Team explores strategies for correcting mutations that cause stroke
Cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL) is a rare, severe, and deadly genetic disorder characterized by damage to small blood vessels in the brain. The condition ...
12 hours ago
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Genetics
Study reveals secrets of energy metabolism, promising better blood transfusions
Researchers at the University of Colorado School of Medicine have uncovered insights into how red blood cells function and survive during storage—discoveries that could lead to better outcomes for patients receiving blood ...
14 hours ago
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Novel protein detects and responds to changes in blood flow
When blood moves through your body, it exerts a frictional force on the walls of blood vessels. This force, known as fluid shear stress, has important effects on vascular development, function, and disease.
13 hours ago
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Study identifies epigenetic 'switches' that regulate the developmental trajectories of single cells
Individual cells in the human body develop progressively over time, ultimately becoming specialized in specific functions. This process, known as cell differentiation or specialization, is central to the formation of distinct ...
Preclinical data suggest antioxidant strategy to address mitochondrial dysfunction caused by SARS-CoV-2 virus
Building upon groundbreaking research demonstrating how the SARS-CoV-2 virus disrupts mitochondrial function in multiple organs, researchers from Children's Hospital of Philadelphia (CHOP) demonstrated that mitochondrially-targeted ...
Jul 15, 2024
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How a gene for obesity affects the brain
Obesity is a complicated condition, caused by a combination of genetics, the food environment, behavior, and other factors. For millennia, getting enough food to survive and thrive was difficult. For most people, it's now ...
Jul 15, 2024
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Unlocking the mystery of preexisting drug resistance: Study sheds light on cancer evolution
The evolution of resistance to diseases, from infectious illnesses to cancers, poses a formidable challenge.
Jul 15, 2024
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Study reveals gene 'switched off' in early stages of pancreatic cancer allows rapid tumor growth and spread
Scientists at Nottingham Trent University, the University of Nottingham, Stanford University and the University of California and Cedars-Sinai Medical Center, Los Angeles, have found that the molecule "HNF4A" suppresses pancreatic ...
Jul 15, 2024
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Personalized simulations predict patient outcomes for blood cancer treatment in breakthrough study
A study led by researchers at Brighton and Sussex Medical School (BSMS) has unveiled an approach to predicting the effectiveness of treatments for patients with diffuse large B-cell lymphoma (DLBCL), a common form of blood ...
Jul 15, 2024
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Tell-tale gene affects success of drug used to treat chronic pain, study finds
Women who carry a particular form of a pain gene are more likely to respond well to a common medication used to treat long-term discomfort, research shows.
Jul 15, 2024
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How guardian proteins change from inhibitors to promoters of cancer
"Who will watch the watchers?" asked Roman poet Juvenal way back in the first century C.E. Nature has been addressing that very question for much, much longer. The human body contains proteins that are designed to protect ...
Jul 12, 2024
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Stress-related genes may contribute to aggressive prostate cancer in African American men
Those living in disadvantaged neighborhoods have significantly higher activity of stress-related genes, new research suggests, which could contribute to higher rates of aggressive prostate cancer in African American men. ...
Jul 12, 2024
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Researchers identify new mutation in gene linked to amyotrophic lateral sclerosis
Researchers have identified a new mutation in the ARPP21 gene that could be the cause of amyotrophic lateral sclerosis (ALS), a devastating neurodegenerative disease. The researchers are from the Neuromuscular Diseases Group ...
Jul 12, 2024
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Scientists uncover novel major risk gene for autoimmune thyroid disease
Scientists at deCODE genetics have published a study in Nature Communications, comparing over 110 thousand patients with autoimmune thyroid disease (AITD) from Iceland, Finland, UK and U.S. with 1.1 million controls. The ...
Jul 12, 2024
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Discovery of gene linked to neurodevelopmental disorders offers hope for future treatments
A global collaboration involving University of Manchester scientists has discovered a gene whose variants potentially cause neurodevelopmental disorders (NDDs) in hundreds of thousands of people across the world.
Jul 11, 2024
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Vegetarian diet benefits aren't one-size-fits-all, says study
When it comes to determining whether a vegetarian diet is right for you, genetics are an important part of the equation, according to a new study from the University of Georgia.
Jul 11, 2024
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Understanding the roots of chronic pain—research suggests new target for analgesics
A team of researchers led by Oscar Sánchez-Carranza in Professor Gary Lewin's lab at the Max Delbrück Center have identified a new function for the PIEZO2 protein—in mediating chronic pain hypersensitivity. The research ...
Jul 11, 2024
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New discovery suggests opportunity to improve effectiveness of KRAS inhibitors against pancreatic cancer
Mutations in the KRAS gene are the primary driver of pancreatic cancer. A new class of drugs known as KRAS inhibitors is showing initial promise in clinical trials, but many tumors quickly develop resistance to the treatment.
Jul 11, 2024
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Novel genome editing approach restores hearing in adult preclinical models with genetic deafness
Mass Eye and Ear researchers restored hearing in preclinical mouse models with a specific form of inherited deafness called DFNA50 caused by mutations in microRNA, by using a novel in vivo CRISPR genome editing approach. ...
Jul 11, 2024
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Researchers pave way to target an autoimmune disease-associated gene variant
In a new study, Yale researchers identified a molecule that binds to a disease-associated macrophage migration inhibitory factor (MIF) gene variant. The discovery, they say, could lead to the development of a new generation ...
Jul 11, 2024
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