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Genetics news
Genetics
Sustained visual improvements in LHON patients treated with AAV gene therapy
A multinational study led by the LHON Study Group has revealed sustained visual improvements and a favorable safety profile five years following lenadogene nolparvovec gene therapy in patients with Leber hereditary optic ...
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Oncology & Cancer
New genetic mutation found to suppress cancer growth
UT Southwestern Medical Center researchers have identified a genetic mutation that slows the growth of melanoma and potentially other cancers by harnessing the power of the immune system. Their findings, published in the ...
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Digital twin research finds colon cancer cells can be reverted to normal cells
Despite the development of numerous cancer treatment technologies, the common goal of current cancer therapies is to eliminate cancer cells. This approach, however, faces fundamental limitations, including cancer cells developing ...
Dec 23, 2024
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Gene editing tool reduces Alzheimer's plaque precursor in mice
A new gene editing tool that helps cellular machinery skip parts of genes responsible for diseases has been applied to reduce the formation of amyloid-beta plaque precursors in a mouse model of Alzheimer's disease, researchers ...
Dec 23, 2024
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Promising biomarker could decode cause of aggressive breast cancer in women of color
Triple-negative breast cancer (TNBC) is an aggressive breast cancer. It spreads quickly and has few treatment options. It is also serious because of its rate of recurrence.
Dec 20, 2024
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Multiple sclerosis brain atlas could pave way for personalized treatments
An international research team, including researchers at Karolinska Institutet, has mapped the genes expressed in the brain cells of people with multiple sclerosis (MS). The atlas, which is presented in the journal Neuron, ...
Dec 20, 2024
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CRISPR study silences gene mutations that drive aggressive cancers
Peter Mac scientists have found a way to use the powerful gene editing tool CRISPR to silence cancer-causing gene mutations which, up to now, have remained off-limits to targeted drugs.
Dec 19, 2024
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Previously unknown genetic links provide insights into autism's prevalence among males
Research published in The American Journal of Human Genetics has identified a previously unknown genetic link to autism spectrum disorder (ASD). The study found that variants in the DDX53 gene contribute to ASD, providing ...
Dec 19, 2024
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New findings expand genetic knowledge of autism underpinnings
Hundreds of novel genetic variants across an ancestrally diverse cohort of 195 families, including 222 people with autism spectrum disorder (ASD), have been identified by researchers at UT Southwestern Medical Center, expanding ...
Dec 19, 2024
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Placental genes study explores how assisted reproduction affects children's development
Approximately one in six couples trying to have a child experiences infertility. Each year, over five percent of children in Finland are born with the help of Assisted Reproductive Technology (ART), and to date, over ten ...
Dec 19, 2024
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Overcoming glioblastoma resistance to chemotherapy
In spite of intensive research, glioblastoma remains one of the most lethal types of brain cancer. Temozolomide (TMZ) is used as the front-line medicine in its treatment.
Dec 19, 2024
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Combining long- and short-read sequencing in single cells reveals new mRNAs in neurodegenerative diseases
Diseases marked by progressive deterioration of the brain—neurodegeneration—have proven challenging to understand and treat. These common conditions affect millions of patients and families around the world, yet efforts ...
Dec 19, 2024
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Large-scale study links dyslexia genetics to brain structure
Dyslexia is a common learning difficulty in which genes often play a role. How do genes associated with dyslexia relate to brain structure in the general population? In a large-scale study published in Science Advances, a ...
Dec 18, 2024
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Genetic testing changes course of care in children with neurodevelopmental conditions
Adding genetic testing to the evaluation of pediatric patients with neurodevelopmental disorders (NDD) resulted in more individualized care, including changes in medication, referrals to clinical trials or specialists, and ...
Dec 18, 2024
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New gene therapy could alleviate chronic pain, researchers find
Pain is meant to be a defense mechanism. It creates a strong sensation to get us to respond to a stimulus and prevent ourselves from further harm. But, sometimes injuries, nerve damage, or infections can cause long-lasting, ...
Dec 17, 2024
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Putting the brakes on prostate cancer cells: Androgen receptor can alter normal prostate growth
Prostate cancer hijacks the normal prostate's growth regulation program to release the brakes and grow freely, according to Weill Cornell Medicine researchers. The discovery, published Dec. 13 in Nature Communications, paves ...
Dec 17, 2024
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Genetic testing moving into the mainstream, study finds
Genetic testing, which has expanded in recent years with advances in technology and the development of consumer products, is on a path to widespread acceptance in the U.S., researchers at UT Southwestern Medical Center found. ...
Dec 17, 2024
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Gene inhibition provides potential way to overcome cancer cells' resistance to chemotherapy drug cisplatin
A new study from Cedars-Sinai Cancer reveals a potential way to overcome tumor resistance to a common chemotherapy drug called cisplatin. The study, published in Science Advances, could improve the effectiveness of the widely ...
Dec 16, 2024
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Researchers discover molecular events leading to Rett syndrome
Researchers at Baylor College of Medicine, Jan and Dan Duncan Neurological Research Institute (Duncan NRI) at Texas Children's Hospital and collaborating institutions have gained new insights into the molecular changes leading ...
Dec 16, 2024
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Collaborative seeks to change children's lives through genetics
A 14-year-old girl was having back pain after a car accident and visited an orthopedic clinic at Boston Children's Hospital. In the course of her care, she joined the Children's Rare Disease Collaborative (CRDC), a hospital-wide ...
Dec 14, 2024
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Key genetic mechanism provides insights into facial development and congenital issues
An international team of researchers has identified a key genetic mechanism that regulates the formation and migration of cranial neural crest cells, which are essential for developing facial structures.
Dec 13, 2024
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Mini-brains reveal how mitochondrial mutations affect brain cells
Researchers at the University of Bergen have used advanced stem cell technology to develop mini-brains, also called brain organoids, that can mimic disease processes caused by mitochondrial failure. This could open new avenues ...
Dec 13, 2024
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How DNA shapes reproductive health, fertility and even life expectancy
Led by researchers from the University of Oxford's Leverhulme Center for Demographic Science and the University of Iceland, a review, published in Nature Aging, explores how genetic variations can explain differences in reproductive ...
Dec 13, 2024
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Genetic toolkit uses mouse models to modify and investigate gene function
A team at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) has developed a comprehensive set of innovative genetic tools and mouse lines, called iFlpMosaics, designed to enhance the study of gene function and ...
Dec 13, 2024
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High-altitude gene variant linked to better blood cancer prognosis
Two researchers from Huntsman Cancer Institute at the University of Utah (the U) have discovered a gene variant found in high-altitude Andean populations that they believe could be a new biomarker for predicting the severity ...
Dec 13, 2024
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