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Genetics news
Genetics
New study reveals how DNA repair genes play a major role in Huntington's disease
A new UCLA Health study has discovered in mouse models that genes associated with repairing mismatched DNA are critical in eliciting damages to neurons that are most vulnerable in Huntington's disease and triggering downstream ...
6 hours ago
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Oncology & Cancer
Disruption of a single amino acid in a cellular protein makes breast cancer cells behave like stem cells
Vimentin is a type III intermediate filament (IF) protein normally expressed in cells that develop into connective tissue, blood vessels, and lymphatic tissue (mesenchymal cells). Despite being widely studied, its role in ...
9 hours ago
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Unexpected X chromosome findings challenge assumptions about sex differences in human disease
Researchers at Linköping University in Sweden made an unexpected discovery while investigating genetically unique women. Their insights advance our understanding of our most enigmatic chromosome, the X chromosome.
9 hours ago
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Genetic map identifies 1,000 potential kidney disease treatment targets
More than 1,000 genes may serve as possible treatment targets for individuals with kidney disease, according to a new study, published in Science, by researchers at the Perelman School of Medicine at the University of Pennsylvania.
9 hours ago
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Second-hand smoke exposure during childhood leaves its mark on children's DNA
Children exposed to second-hand smoke at home are more likely to show certain changes in the epigenome, which can alter the way genes are expressed. These epigenetic changes could influence the development of diseases in ...
3 hours ago
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Urine test offers simpler diagnosis for mitochondrial disorders, study finds
New research at the University of Alberta may make it easier to diagnose serious diseases that disrupt the body's energy supply.
8 hours ago
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Breast cancer's genomic architecture: A new classification system emerges
Breast cancers can be classified into subgroups that hint at the aggressiveness of the cancer and the likelihood that the patient will experience a recurrence years after their initial diagnosis.
Feb 10, 2025
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Sickle cell disease is a genetic disorder that causes lifelong suffering—here's what you need to know
Right now, approximately 20 billion red blood cells are busy traveling through your blood vessels. They are delivering oxygen to all the different tissues in your body and removing carbon dioxide to be breathed out of your ...
Feb 10, 2025
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How genetics, lifestyle promote cognitive health in older adults
For the first time, University of Hawaiʻi at Mānoa researchers have studied how work, volunteering and leisure activities affect brain health in older adults from diverse backgrounds, while also factoring in a genetic risk ...
Feb 10, 2025
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Genetic overlaps in 72 long-term health conditions identified
The largest study to date to analyze millions of both genetic and patient records on the long-term health conditions of later life has identified opportunities for new ways to prevent and treat multiple overlapping conditions.
Feb 7, 2025
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Epistasis: Unlocking the secrets of complex diseases
Imagine your doctor calls you to discuss the results of your genetic testing. They tell you your results indicate you are highly likely to develop Alzheimer's disease. But not to worry, because they caught it early, you can ...
Feb 7, 2025
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New work proposes a unifying model of Alzheimer's disease: Large-scale alterations to gene expression
In a novel theory, scientists at Arizona State University's Biodesign Institute propose a unifying explanation for the molecular chaos driving Alzheimer's disease. The condition causes widespread disruption of gene behavior, ...
Feb 6, 2025
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Using genetics to identify individuals with undiagnosed chronic obstructive pulmonary disease
In a recent study, Mass General Brigham researchers demonstrated that through low-cost genetic samples that can be obtained from a cheek swab or blood test, they can improve identification of people with COPD in the community.
Feb 6, 2025
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Researchers identify potential drug targets for future heart failure therapeutics
Heart failure remains a substantial burden for patients due to its high prevalence and limited therapeutic options. Heart failure is classified into two major clinical subtypes—heart failure with preserved ejection fraction ...
Feb 6, 2025
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Researchers uncover the source of cells that contribute to pulmonary fibrosis
Researchers have been trying for decades to stop the cells that damage the lung in people with pulmonary fibrosis. Now a team of Columbia and UCSD researchers may have found a clever solution that sidesteps the difficulty ...
Feb 5, 2025
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RAD51 biomarker could complement next-generation sequencing in personalizing prostate cancer treatment
Published in Cell Reports Medicine, results of a VHIO-led study support the feasibility of using RAD51 testing to complement next-generation sequencing (NGS) for precise patient stratification and treatment selection in metastatic ...
Feb 5, 2025
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Inhibiting a gene provides a new weapon to fight treatment-resistant melanoma
The lab of The Wistar Institute's Jessie Villanueva, Ph.D., has identified a new strategy for attacking treatment-resistant melanoma: inhibiting the gene S6K2. The team has published their findings in a paper titled "Selective ...
Feb 5, 2025
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Mutations in two gene pairs point to a promising drug target in 5% of adult cancers
Scientists from the Cancer Dependency Map (DepMap) at the Broad Institute of MIT and Harvard and Columbia University have discovered that about 5% of adult cancers rely heavily on a gene called PELO to survive and that disabling ...
Feb 5, 2025
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How healthy stem cells turn into oral cancer
Nearly 60,000 people are diagnosed with oral cancer in the U.S. every year, according to the American Cancer Society, and the rate of new cases continues to rise. Now, researchers at University of California San Diego have ...
Feb 4, 2025
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How hungry fat cells could someday starve cancer to death
Liposuction and plastic surgery aren't often mentioned in the same breath as cancer. But they are the inspiration for a new approach to treating cancer that uses engineered fat cells to deprive tumors of nutrition.
Feb 4, 2025
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Disrupting the RBM42 protein could throw a wrench in the gears of cancer's growth
For decades, scientists have tried to stop cancer by disabling the mutated proteins that are found in tumors. But many cancers manage to overcome this and continue growing. Now, UCSF scientists think they can throw a wrench ...
Feb 4, 2025
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Comprehensive genetic analysis identifies protective factors against Alzheimer's disease
An international research team led by the Hong Kong University of Science and Technology (HKUST) has identified key genetic factors that confer protective effects against Alzheimer's disease (AD) through a comprehensive genetic ...
Feb 4, 2025
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New insights into liver maturation and specialization could advance regenerative medicine
Researchers from the University of Illinois have identified a key process coordinating liver maturation and polyploidization, a state in which cells carry more than two sets of chromosomes. Their findings, published in Genes ...
Feb 4, 2025
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Scientists discover how genetic risk for alcoholism changes brain cell behavior
Rutgers Health researchers have discovered that brain immune cells from people with a high genetic risk for alcohol use disorder (AUD) behave differently than cells from low-risk people when exposed to alcohol.
Feb 3, 2025
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Heart health differences in men and women: Tiny RNA molecules play key role, study finds
There are notable differences between men and women in their susceptibility to many human diseases, including cardiovascular disease. For example, women typically have smaller hearts that pump faster, while men have larger ...
Feb 3, 2025
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