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Clinical pharmacology news
Metformin's real power may be in the gut
For decades, physicians and scientists thought metformin, the leading type 2 diabetes medication taken by millions worldwide, mainly targets the liver to suppress glucose production. But a new Northwestern University study ...
2 hours ago
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Leukemia stem cells cause treatments to fail, but findings open new avenues to overcome resistance
Scientists from the German Cancer Research Center (DKFZ) and the HI-STEM Stem Cell Institute have deciphered a key mechanism that contributes to treatment failure in acute myeloid leukemia (AML). They show that there are ...
12 hours ago
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Garlic-derived compound shows potential to improve muscle health during aging
Can a compound derived from a common kitchen ingredient help support muscle health during aging? A new study suggests it can. The study reveals that S-1-propenyl-L-cysteine (S1PC), a bioactive compound found in aged garlic ...
20 hours ago
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Scientists take crucial step in developing world's first measles treatment
Scientists at La Jolla Institute for Immunology (LJI) are the first in the world to characterize human antibodies capable of neutralizing measles virus. These antibodies bind to key sites on measles virus and prevent the ...
20 hours ago
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FDA approves Auvelity for Alzheimer's disease-related agitation
The U.S. Food and Drug Administration has approved the expanded use of Axsome Therapeutics' Auvelity (dextromethorphan hydrobromide and bupropion hydrochloride) extended-release tablets to treat adults with agitation associated ...
10 hours ago
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Can peptide injections help people recover from injuries? Here's what you need to know
It's tough to avoid the current hype about the health benefits of injecting peptides. Although these substances—essentially, synthetic bits of protein in solution—have long made the rounds in the fitness world, their popularity ...
18 hours ago
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New research raises concerns about safety of higher-THC medicinal cannabis products in Australia
New Monash University research has found that more than half of all adverse events reported to Australia's medicines regulator involving medicinal cannabis were linked to higher-THC products, with psychiatric disorders the ...
23 hours ago
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Key magic mushroom ingredient makes fish less aggressive and lazier
More than 200 mushrooms—primarily those belonging to a genus of gilled mushrooms called Psilocybe—contain the psychoactive compound psilocybin. In the brain of mammals, this chemical can bind to serotonin receptors and influence ...
May 7, 2026
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Direct-to-proteasome strategy degrades two cancer proteins and may curb drug resistance
A preclinical study has developed a strategy that enables the forced elimination of proteins that help tumors survive chemotherapy. This finding opens a new avenue to tackle resistance to cancer treatments, one of the major ...
May 6, 2026
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New GlyT2 blocker relieves chronic neuropathic pain without major side effects
Chronic neuropathic pain remains one of the most challenging conditions to treat, with current therapies offering limited benefit and being over-reliant on opioids. Researchers at Rensselaer Polytechnic Institute (RPI), along ...
May 6, 2026
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Oral small-molecule GLP-1 drugs penetrate deep into the brain to suppress cravings
A study has found that an emerging class of GLP-1 weight-loss drugs suppresses eating for pleasure, or hedonic feeding, in mice by modulating a reward circuit deep within the brain. This newly charted pathway—separate from ...
May 6, 2026
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Certain migraine prevention drugs associated with reduced risk of glaucoma
A type of drug used to prevent migraine may be associated with a reduced risk of glaucoma, according to a study published in Neurology. The study compared 36,822 people who took calcitonin gene-related peptide (CGRP) inhibitor ...
May 6, 2026
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Lithium uncovers fresh Alzheimer's targets beyond Tau
Lithium chloride may affect many cellular level changes in Alzheimer's disease, a new study from the University of Eastern Finland (UEF) shows. The work is published in the journal Biomedicine & Pharmacotherapy.
May 6, 2026
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How changes to proteins can alter drug interactions for new precision therapies
Inside every human cell, proteins are constantly being tagged with small chemical modifications after they're produced. Known as post-translational modifications, or PTMs, these can change how a protein folds, where it travels ...
May 6, 2026
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Blood protein study of 78,000 people uncovers disease mechanisms and drug repurposing leads
Involving a collaboration with 118 investigators contributing from 89 institutions, scientists from Queen Mary University of London's Precision Healthcare University Research Institute and Berlin Institute of Health (BIH) ...
May 6, 2026
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The peptide problem: Hype is outrunning the evidence
Health Canada recently warned Canadians not to buy or inject unauthorized peptide drugs sold online, naming products that include BPC-157, CJC-1295, ipamorelin, TB-500 and retatrutide.
May 6, 2026
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Vitamin C and cancer: Was Nobel laureate Linus Pauling on to something?
Linus Pauling was one of the most brilliant scientists of the 20th century. He won two Nobel prizes and transformed our understanding of chemical bonds and the structure of proteins. Late in his career, though, he became ...
May 6, 2026
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Clinical trials that are actually marketing ploys targeting doctors: How seeding trials put profit over patients
Some clinical trials aren't designed to answer scientific questions. They're designed to market drugs. In our recently published research, my team and I analyzed over 34,000 industry-funded trials and found that hundreds ...
May 6, 2026
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Bariatric surgery significantly more effective than GLP-1 drugs for weight loss and disease remission, review finds
Metabolic and bariatric surgery delivers significantly greater weight loss and higher rates of obesity-related disease remission than glucagon-like peptide-1 receptor agonists (GLP-1s), according to one of the largest and ...
May 6, 2026
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Higher steroid use linked to poorer mental health
Riskier anabolic-androgenic steroid (AAS) use has been linked to poorer mental health symptoms, new Griffith University research has found. Ph.D. Candidate Ben Bonenti from Griffith's School of Applied Psychology examined ...
May 6, 2026
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Concerns raised on gaps in health care for released prisoners
People leaving prison in England can experience avoidable gaps in their medication because of fragmented health care systems, poor information sharing, and discharge processes which are sometimes rushed due to release procedures, ...
May 6, 2026
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Alzheimer's drug development pipeline shows impressive growth and diversity of therapies
Researcher Jeffrey L. Cummings M.D., ScD, from the Kirk Kerkorian School of Medicine at UNLV, has released his annual report on the global effort to find a cure for Alzheimer's. The work is published in the journal Alzheimer's ...
May 5, 2026
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Newer migraine drugs reduce headache days with fewer side effects
Chronic migraine can be difficult to treat—but new research is helping identify the most effective options. In a large new review, published in the Annals of Internal Medicine, researchers analyzed 43 clinical trials involving ...
May 5, 2026
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Combination therapy could improve outcomes in the most difficult-to-treat patients with inflammatory bowel disease
For patients with Crohn's disease or ulcerative colitis who have exhausted other treatment options, a new combination therapy is showing results that offer hope for one of medicine's most treatment-resistant populations, ...
May 5, 2026
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Study finds bariatric surgery less costly than GLP-1 drugs over time
A new real-world analysis of more than 90,000 patients with obesity and type 2 diabetes finds metabolic and bariatric surgery costs significantly less than weekly injections of GLP-1 drugs over a two-year period, according ...
May 5, 2026
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