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Clinical pharmacology news
Reverse engineering ketamine's effects may lead to new antidepressants
Weill Cornell Medicine investigators have "reverse engineered" ketamine's antidepressant effects to identify potential new strategies for treating depression. While there are many effective treatments available for depression, ...
10 hours ago
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FDA approves once-daily Idvynso tablet for treating HIV
The U.S. Food and Drug Administration has approved Merck's Idvynso (doravirine/islatravir), a new, once-daily, two-drug single tablet for the treatment of HIV-1 infection in adults to replace the current antiretroviral regimen ...
2 hours ago
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CDK inhibitors show wider cancer potential as combinations and biomarkers advance
Worldwide, more than a million breast cancer patients have been treated with cyclin-dependent kinase 4/6 (CDK4/6) inhibitors, which slow or stop the uncontrolled multiplication of cancer cells. Researchers see untapped potential ...
12 hours ago
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The Bangui operation: A story of blood, science and biomedical exploitation
In the early 1990s, a secret HIV vaccine research project was carried out in the Central African Republic. The project didn't yield results and was hidden for many years. Today it sheds light on debates over clinical trials, ...
15 hours ago
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Small dose of antibiotic yields good results in treating panic attacks
A study shows that small doses of the antibiotic minocycline may help treat panic disorder. Experiments conducted at São Paulo State University (UNESP) in mice and at the Federal University of Rio de Janeiro (UFRJ) in humans ...
Apr 30, 2026
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Brazilian tree compounds block SARS-CoV-2 at multiple stages, lab tests show
A study has revealed that galloylquinic acids extracted from the leaves of Copaifera lucens Dwyer, a tree endemic to Brazil primarily found in the Atlantic Forest, have a multi-targeted effect against SARS-CoV-2, the virus ...
Apr 30, 2026
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Novel theranostic approach for radioimmunotherapy achieves curative responses in colorectal cancer tumors
A new pretargeted radioimmunotherapy (PRIT) technique has been shown to be safe and effective in eradicating tumors from a preclinical colorectal cancer model. The multi-step theranostic approach delivers alpha-emitting radiation ...
Apr 30, 2026
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AI-assisted approach identifies IRS4 as a promising drug target in multiple solid tumors
Leveraging AI capabilities combined with genetic data led St. Jude Children's Research Hospital investigators to predict new cancer drug targets that carry a limited risk of side effects. For their study, published in Science ...
Apr 30, 2026
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Scientists discover new way to make drug-resistant cancer treatable again
Cancer cells survive by repairing damage to their DNA—even damage that would normally be fatal. One of their most important defense systems is homologous recombination, a high-precision repair pathway that fixes broken DNA ...
Apr 30, 2026
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Targeted 'biological missile' blocks leukemia growth while sparing healthy tissue
New research out of VCU Massey Comprehensive Cancer Center has uncovered a targeted cancer therapy that significantly prevents leukemia progression, improves survival rates and minimizes damage to surrounding healthy tissue.
Apr 30, 2026
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GLP-1 drugs have long-term benefit for heart health, review suggests
New research has shown that GLP‑1 weight-loss drugs deliver protection against heart attacks, strokes, and premature death over a sustained period of time. Researchers from Anglia Ruskin University (ARU) analyzed data from ...
Apr 30, 2026
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GLP-1 reduces heavy drinking days in treatment seeking people with alcohol use disorder and obesity, finds small trial
A trial of 108 adults with obesity seeking treatment for alcohol use finds a once-weekly semaglutide injection reduced heavy drinking days in the past 30 days by an average of roughly 12 days, 50% higher than the eight-day ...
Apr 30, 2026
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When promising cures collapse before they reach patients
Hospitals filled to capacity. Case counts climbing by the hour. Quarantine became routine. It was the beginning of the COVID-19 pandemic. The world needed a vaccine that didn't exist, and there was no clear timeline for one. ...
Apr 30, 2026
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Q&A: Coniferous resin and its extracts in wound healing—from folk tradition to modern medicine
Interest in plant-based wound treatments has grown due to traditional method limitations, antimicrobial resistance, and the need for safer options. Coniferous resin from Norway spruce (Picea abies) has been used in Northern ...
Apr 30, 2026
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Autonomous AI renews 192 drugs in Utah pilot, exposing safety and legal gaps
A first-of-its-kind pilot program in Utah developed by a health-technology startup company uses artificial intelligence to automatically renew certain prescriptions for patients with chronic conditions such as hypertension ...
Apr 29, 2026
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One molecule, two effects: A new drug concept to treat obesity and type 2 diabetes
A team led by metabolism researcher Prof Timo D. Müller at Helmholtz Munich has developed a new approach for treating obesity and type 2 diabetes: a hybrid molecule uses the well-known GLP-1/GIP signaling pathway as a "door ...
Apr 29, 2026
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New HIV vaccine design trains immune system to hit shared viral target across variants
Researchers at Karolinska Institutet, in collaboration with colleagues at The Scripps Research Institute and Emory University, have developed a new vaccine strategy that has generated antibodies capable of neutralizing highly ...
Apr 29, 2026
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Rethinking mRNA vaccines: Liver targeting can suppress immunity, while muscle boosts it
A new study by researchers at the Icahn School of Medicine at Mount Sinai overturns a longstanding assumption about how mRNA vaccines generate immunity, revealing that certain non-immune cells help determine vaccine effectiveness.
Apr 29, 2026
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Preclinical efficacy of experimental peptide therapy suggests a new target for metastatic breast cancer treatments
A peptide that successfully targeted and killed metastatic cancer cells in mice may open the door to developing more efficient ways to detect and treat metastatic breast cancer in humans, UTHealth Houston researchers have ...
Apr 29, 2026
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Sedatives in pregnancy not linked to psychiatric disorders in children
A large South Korean study published by The BMJ finds no increased risk of psychiatric or neurodevelopmental disorders, such as ADHD and autism, in children whose mothers used sedative drugs (benzodiazepines or Z-hypnotics) ...
Apr 29, 2026
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Choosing safer diabetes medications for older adults
Older adults with type 2 diabetes face a difficult trade-off: they are among the most vulnerable to medication-related harms yet are often underrepresented in the clinical trials that guide treatment decisions. A new study ...
Apr 29, 2026
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Integrating pharmacists into kidney disease care team can provide better outcomes for patients
Approximately 35 million adults in the United States suffer from chronic kidney disease (CKD), and that number is growing. Meanwhile, there's a critical shortage of nephrologists to manage these patients, according to Calvin ...
Apr 29, 2026
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Reclassification of marijuana opens doors for much‑needed medical research into the benefits and risks of the drug
When the U.S. Department of Justice moved to reclassify medical marijuana to a Schedule III drug on April 23, 2026, it set the stage for a vast amount of medical research that has been hobbled for decades by its more restrictive ...
Apr 29, 2026
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FDA moves to real-time clinical trial patient monitoring, faster drug review
The U.S. Food and Drug Administration (FDA) is moving to speed drug development and review by launching real-time clinical trials.
Apr 29, 2026
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Anti-inflammatory drug shows potential for improved blood formation and treatment of bone damage
Researchers at Dresden University Hospital may have discovered a new therapeutic approach for treating myelodysplastic syndromes (MDS). In a recent study, the team headed by Prof. Manja Wobus and Dr. Katja Sockel demonstrated ...
Apr 29, 2026
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