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Clinical pharmacology news

Metformin's real power may be in the gut

For decades, physicians and scientists thought metformin, the leading type 2 diabetes medication taken by millions worldwide, mainly targets the liver to suppress glucose production. But a new Northwestern University study ...

Leukemia stem cells cause treatments to fail, but findings open new avenues to overcome resistance

Scientists from the German Cancer Research Center (DKFZ) and the HI-STEM Stem Cell Institute have deciphered a key mechanism that contributes to treatment failure in acute myeloid leukemia (AML). They show that there are ...

Lithium uncovers fresh Alzheimer's targets beyond Tau

Lithium chloride may affect many cellular level changes in Alzheimer's disease, a new study from the University of Eastern Finland (UEF) shows. The work is published in the journal Biomedicine & Pharmacotherapy.

Higher steroid use linked to poorer mental health

Riskier anabolic-androgenic steroid (AAS) use has been linked to poorer mental health symptoms, new Griffith University research has found. Ph.D. Candidate Ben Bonenti from Griffith's School of Applied Psychology examined ...

Concerns raised on gaps in health care for released prisoners

People leaving prison in England can experience avoidable gaps in their medication because of fragmented health care systems, poor information sharing, and discharge processes which are sometimes rushed due to release procedures, ...

Why are medications administered in different forms?

Medications are available and delivered in various forms, including liquids, pills, injections, IV drips, inhalants, and suppositories, to name a few. But what makes one option, otherwise known as a delivery system, better ...

Cranberry juice may boost UTI antibiotics

More than 400 million people experience a urinary tract infection every year, and some epidemiological studies estimate that more than half of all women will develop at least one in their lifetime. Most UTIs are caused by ...

FDA approves once-daily Idvynso tablet for treating HIV

The U.S. Food and Drug Administration has approved Merck's Idvynso (doravirine/islatravir), a new, once-daily, two-drug single tablet for the treatment of HIV-1 infection in adults to replace the current antiretroviral regimen ...

When promising cures collapse before they reach patients

Hospitals filled to capacity. Case counts climbing by the hour. Quarantine became routine. It was the beginning of the COVID-19 pandemic. The world needed a vaccine that didn't exist, and there was no clear timeline for one. ...