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Clinical pharmacology news
Discovering a new layer of control for a decades-old leukemia drug
For more than 70 years, the drug 6-thioguanine (6-TG) has been used to treat leukemia. Although its clinical effects have been studied extensively, scientists are still uncovering the molecular mechanisms that determine whether ...
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Leucovorin prescriptions for children rise 46% after federal officials' autism claims
Leucovorin prescriptions for children spiked after federal officials claimed the drug was an effective treatment for autism during a September 2025 press conference, according to a new Michigan Medicine-led study published ...
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Humanized mouse model could significantly improve preclinical research on drugs for celiac disease
Celiac disease is an autoimmune disorder in which the immune system reacts to gluten. More than 1% of the population in Germany is affected. In these individuals, gluten proteins found in wheat, rye and barley trigger inflammation ...
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Could salmon and other fatty fish unlock new treatments for severe lung disease?
Lung inflammation and injury can quickly turn into acute respiratory distress syndrome (ARDS) in patients with pneumonia, COVID-19 and other conditions.
8 hours ago
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An origami-inspired implant could monitor health from beneath the skin
The skin is the body's largest organ. It is a protective shield that keeps harmful pathogens out and vital fluids inside. These very properties make it a tough engineering challenge to design wearable health sensors because ...
Cell-surface receptors guide antisense therapy to mutant KRAS in pancreatic cancer cells
Antisense oligonucleotides (ASOs) have been proposed as a therapeutic approach to shut down the production of faulty proteins in a wide variety of diseases, including cancer. In a study published in the Journal of Cell Biology ...
Aug 11, 2026
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Reinitiating obesity meds after bariatric surgery tied to greater one-year weight loss in youths
Restarting obesity medications, including glucagon-like peptide-1 (GLP-1) receptor agonists, soon after sleeve gastrectomy (SG) is associated with greater one-year weight loss than surgery alone in adolescents, according ...
Aug 11, 2026
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Multiple bioactive compounds drive antimicrobial properties of mānuka honey, study finds
New research at Aston University has shown that a variety of compounds are responsible for the antimicrobial action of mānuka honey, not just the sugar content and methylglyoxal (MGO) alone, as previously thought. The paper ...
Aug 11, 2026
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Unexpected brain mechanism challenges assumptions about GLP-1s
For decades, obesity medications produced only modest weight loss. But in recent years, Ozempic and related GLP-1 therapies have transformed the field, enabling sustained weight loss of 10% to 15% or more. Despite their success, ...
Aug 10, 2026
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Triple-dose regimen may permanently clear HIV in infected newborns
Every year, more than 120,000 newborns worldwide contract HIV, creating a global health burden that requires lifelong treatment for millions of people—assuming they have access and can afford it. New research led by Oregon ...
Aug 10, 2026
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Patient-derived organoids reveal which breast tumors may resist standard therapies
Researchers at UC San Francisco have developed a new method to predict how different types of breast cancer will respond to treatment, using patient data from the I-SPY2 breast cancer trial and rapid testing on lab-grown ...
Aug 10, 2026
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Study reveals growing signs of malaria drug resistance in Ethiopia
Researchers have identified genetic changes in malaria parasites that may reduce the effectiveness of key antimalarial medicines, highlighting the need for continued surveillance.
Aug 10, 2026
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Study suggests experimental drug dismantles 2 key proteins that help tumors survive, adapt and resist treatment
Scientists from Roswell Park Comprehensive Cancer Center report that the investigational anticancer agent FL118 functions as a dual molecular glue degrader that directly targets and degrades the proteins DDX5 and UbE2T, two ...
Aug 10, 2026
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DIY peptide injections are risky
DIY peptide injections, which promise to boost everything from weight loss and muscle-building to longevity and sexual health, are a high-risk wellness fad that keeps growing.
Aug 10, 2026
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Researchers help identify new Ebola variant and potential treatment
When the World Health Organization declared an Ebola outbreak in Uganda and the Democratic Republic of the Congo (DRC) a Public Health Emergency of International Concern in May, scientists around the world mobilized to help. ...
Aug 10, 2026
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New targeting method separates opioid pain relief from reward learning in mice
Researchers at Duke University School of Medicine are investigating how to keep opioids' pain-relieving benefits while reducing their addictive potential. In a study published in Nature, they report a step toward that goal.
Aug 9, 2026
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AI-designed E. coli killer points toward new ways to fight antibiotic-resistant bacteria
In science, the suffix "phage" means to devour. Thus, the name bacteriophage might conjure images of tiny creatures that "eat" bacteria. While that conception isn't 100% scientifically accurate, bacteriophages are lethal ...
Aug 8, 2026
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Malaria vaccine add-ons activate three antibody targets, study finds
Malaria kills more than half a million people a year, most of them young children in Africa. Two vaccines are now recommended by the World Health Organization: RTS,S and R21. Both are helpful interventions, but neither works ...
Aug 8, 2026
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Omega-3 plus low-dose aspirin produces antibiotic-like results against severe periodontitis
A combination of omega-3 and low-dose acetylsalicylic acid (ASA) produced results comparable to antibiotics in treating severe periodontitis. This conclusion is based on a study conducted by researchers affiliated with Albert ...
Aug 7, 2026
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Ketamine triggers morning cortisol surge tied to fewer suicidal thoughts—but the link remains uncertain
In 1970, ketamine was approved as an anesthetic. It works by blocking receptors in the brain. Suicidal tendencies are among the dangers that accompany severe depression. Doctors have found that a low dose of ketamine, much ...
Psychedelics amplify brain connectivity through serotonin receptors, study suggests
Psychedelics like psilocybin (from magic mushrooms), LSD, DMT and mescaline profoundly alter how we perceive, feel and think. After decades of neglect, they are again the subject of serious scientific inquiry, largely because ...
Aug 7, 2026
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How drugs leach out of your sweat (and can spoil your sofa)
Like all consumer products, sofas come with instructions for how best to use and maintain them. But it may surprise you that many furniture companies warn medicines can seep out in your sweat or body oils and damage your ...
Aug 7, 2026
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Finding new osteoarthritis medicines via AI and genetics
Osteoarthritis (OA) is a chronic, painful joint disease and a leading cause of disability. Despite its prevalence, therapies for osteoarthritis are limited and focus on symptom management. Now, researchers are combining genetic ...
Aug 6, 2026
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Why the same antibiotic can cure one infection but fail in another
A group of researchers has uncovered why one common antibiotic works for urinary tract infections but often fails elsewhere, offering greater insight into how the body's own chemistry can determine whether antibiotics succeed ...
Aug 6, 2026
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Single dose of psilocybin for depression shows promising results in UK's first publicly funded randomized trial
The first randomized controlled trial in the U.K. has found that a single dose of psilocybin, the active compound found in "magic mushrooms," produced significant improvements in depression compared with a placebo. This is ...
Aug 6, 2026
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