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Clinical pharmacology news

Discovering a new layer of control for a decades-old leukemia drug

For more than 70 years, the drug 6-thioguanine (6-TG) has been used to treat leukemia. Although its clinical effects have been studied extensively, scientists are still uncovering the molecular mechanisms that determine whether ...

Leucovorin prescriptions for children rise 46% after federal officials' autism claims

Leucovorin prescriptions for children spiked after federal officials claimed the drug was an effective treatment for autism during a September 2025 press conference, according to a new Michigan Medicine-led study published ...

Unexpected brain mechanism challenges assumptions about GLP-1s

For decades, obesity medications produced only modest weight loss. But in recent years, Ozempic and related GLP-1 therapies have transformed the field, enabling sustained weight loss of 10% to 15% or more. Despite their success, ...

DIY peptide injections are risky

DIY peptide injections, which promise to boost everything from weight loss and muscle-building to longevity and sexual health, are a high-risk wellness fad that keeps growing.

How drugs leach out of your sweat (and can spoil your sofa)

Like all consumer products, sofas come with instructions for how best to use and maintain them. But it may surprise you that many furniture companies warn medicines can seep out in your sweat or body oils and damage your ...

Finding new osteoarthritis medicines via AI and genetics

Osteoarthritis (OA) is a chronic, painful joint disease and a leading cause of disability. Despite its prevalence, therapies for osteoarthritis are limited and focus on symptom management. Now, researchers are combining genetic ...

The lightbulb moment behind a potential antiviral breakthrough

An unexpected observation by a University of Queensland researcher could lead to a new treatment for deadly infectious diseases including COVID‑19, pneumonia in infants and children, or viral infections caused by Ebola and ...