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Clinical pharmacology news
Combination treatment could be safer, more effective for drug overdoses involving severe agitation
A team of Marshall University researchers has published a new study suggesting a potential breakthrough in how doctors manage severe agitation caused by methamphetamine and/or cocaine use, particularly in cases in which opioids ...
4 hours ago
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Taking the guesswork out of drug development for Chagas disease
Researchers at Kent have established a computational protocol that could accelerate the development of more effective treatments for life-threatening parasitic infections such as Chagas disease, by enabling scientists to ...
8 hours ago
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Weight-loss drugs could tackle Alzheimer's—study
A new study has found comprehensive evidence that "weight-loss" GLP-1 receptor agonists such as semaglutide are effective in tackling the biological drivers of Alzheimer's disease. The study, published in the journal Molecular ...
11 hours ago
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Depression treatment is shifting, and this mushroom-derived compound is driving one of psychiatry's biggest new tests
Depression is a debilitating mental health disorder that is estimated to affect approximately 5% of people worldwide. It is characterized by persistent feelings of sadness and hopelessness, a lack of interest in everyday ...
WHO approves first malaria treatment for infants
The World Health Organization announced Friday that it had given prequalification approval to a malaria treatment for newborns and infants for the first time.
Apr 25, 2026
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Exploiting a new vulnerability that targets 'zombie' cells as an anticancer therapy
A new set of drugs exploit a recently revealed weakness in "zombie-like"—or senescent—cells that could lead to new treatments for cancer and age-associated diseases. The study from the MRC Laboratory of Medical Sciences (LMS) ...
Apr 24, 2026
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US dentists still prescribe far more opioids for pain than peer nations
People getting their teeth pulled or drilled by dentists in the United States are still much more likely to get powerful opioid medications than dental patients in other developed countries or even the U.S. territory of Puerto ...
Apr 24, 2026
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US approves first gene therapy for rare form of hearing loss
US health officials on Thursday greenlit a first-of-its-kind gene therapy to treat a rare form of hereditary hearing loss, a breakthrough that could pave the way for other such hearing impairment treatments.
Apr 24, 2026
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Clopidogrel seems to outperform aspirin for secondary chronic maintenance therapy
New findings show that switching to clopidogrel, a blood thinner, alone after one year of dual antiplatelet therapy (DAPT) leads to better outcomes than aspirin, even in patients at high risk of bleeding and those who had ...
Apr 24, 2026
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About one-third of children and adolescents use dietary supplements in the US
About one-third of children and adolescents use dietary supplements in the United States, according to a study published online April 24 in Pediatrics Open Science.
Apr 24, 2026
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Freeze-dried platelet product slows swelling and bleeding in traumatic brain injuries
A freeze-dried blood product that could be stored for years on ambulances or in remote emergency departments is showing promise at treating traumatic brain injuries. The news comes from a mouse study done by researchers at ...
Apr 23, 2026
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Paxlovid looked like a COVID game-changer, but in vaccinated adults the real story is far more complicated
The results of two clinical trials—led by the Upstream Lab at St. Michael's Hospital in Toronto and Oxford University, published in the New England Journal of Medicine—provide new evidence to consider when funding, prescribing, ...
Apr 23, 2026
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New cellular target prevents hepatitis E infection
An international team of researchers has identified a promising new approach for treating infections with the Hepatitis E virus (HEV). At the center of the study is the drug Apilimod, which specifically blocks the entry of ...
Apr 23, 2026
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Finding the best dietary supplements for cycling performance—and recovery
Focusing on the rigors of elite cycling, Flinders University experts have put performance-enhancing and other dietary supplements under the microscope, rating some more highly than others. From carbs, beetroot juice and the ...
Apr 23, 2026
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Supplements for menopause: Here's what the evidence actually says
Social media is saturated with menopause solutions: powders for brain fog, gummies for sleep or capsules promising hormonal balance. Supplements such as magnesium, lion's mane, creatine and collagen are being marketed as ...
Apr 23, 2026
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US eases access to marijuana for medical use
The US government on Thursday made it easier for Americans to use cannabis for medical reasons by reclassifying the drug and enabling more research into its safety and efficacy.
Apr 23, 2026
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ADHD treatment despite a history of psychosis: Research finds no increased risk of relapse
People with a history of psychosis often also have attention-deficit/hyperactivity disorder (ADHD). However, treating this condition presents doctors with a clinical dilemma: Psychostimulants are considered effective for ...
Apr 22, 2026
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Kratom use is surging in the US, with life-changing consequences, study reveals
Kratom is a plant with psychoactive properties that, when taken at high doses, can produce effects similar to opioids. A new study published in Addiction has found that kratom use—measured as kratom exposures reported to ...
Apr 22, 2026
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Researchers explore new approach to multivirus drug development
Wanted: a cheap, multipotent treatment for viral infections. Must be able to handle new or unfamiliar strains, or (even better) a broad range of viruses—whatever comes along, in other words. Must be impervious to viral attempts ...
Apr 22, 2026
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'Frankenproteins' offer hope in fighting cancer
Lab-created "frankenproteins" developed by a team of scientists at the University of Toronto Mississauga offer hope for safer and more effective cancer treatments in the future. The protein-based drugs being developed by ...
Apr 22, 2026
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Do drugs that similarly combat a disease have differing effects on quality of life?
A study published in Rheumatology & Autoimmunity challenges the assumption that achieving clinical remission in rheumatoid arthritis is sufficient, showing that patient-reported outcomes vary significantly by drug class even ...
Apr 22, 2026
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Molecular keyhole sheds light on pain and epilepsy
Researchers at VIB, VUB, and KU Leuven have identified a tiny binding site, a molecular "keyhole," in the TRPM3 ion channel, a crucial sensor in pain signaling. TRPM3 is also linked to rare neurodevelopmental disorders and ...
Apr 21, 2026
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Common drug fails to ease knee osteoarthritis pain in largest trial yet
The University of Tasmania's Menzies Institute for Medical Research has found that the commonly prescribed medication, Diacerein, does not improve knee osteoarthritis symptoms, following a national study. Diacerein, a medication ...
Apr 21, 2026
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Alzheimer's drugs offer little benefit, major review finds. And the reasons go deeper than the science
How is it possible to spend tens of billions of dollars developing drugs to treat a serious disease that affects millions of people, and yet end up with something that does not work? This is a mystery that has bedeviled Alzheimer's ...
Apr 21, 2026
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Use of psychotropics increases in the early stages of Parkinson's disease
Up to 1 in 3 people with Parkinson's disease use at least one psychotropic medication, a recent study from the University of Eastern Finland shows. People with Parkinson's disease were using psychotropics more frequently ...
Apr 21, 2026
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