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Clinical pharmacology news
Since the 21st Century Cures Act passed, FDA approvals have relied on fewer studies
Since the passage of the 21st Century Cures Act in 2016, Food and Drug Administration (FDA) approvals for new medical products have relied on fewer studies, according to a study published Aug. 26, 2026, in the PLOS ONE by ...
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Novel molecular shuttle could expand delivery of medicines across the blood–brain barrier
The blood–brain barrier (BBB) is a protective filter that lines the brain's blood vessels and is notoriously hard to penetrate, making the treatment of brain disorders very difficult. Strategies designed to breach the BBB ...
7 hours ago
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What's the latest on 7-OH and kratom availability and addiction care?
For two years, anyone has been able to walk into a vape shop or convenience store in Michigan and other states, hand over cash or a credit card, and walk out with as much of a substance called 7-OH and other related products ...
4 hours ago
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Eminent cardiologist involved in treatment guidelines received £50 million from drug research contracts
A British cardiologist and former president of the European Society of Cardiology (ESC) has been judged by the ESC to have committed severe misconduct after a Danish TV documentary reported that he had been involved in drawing ...
2 hours ago
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Experimental Zika vaccine reveals T cells can drive protection without antibodies
Zika virus has been spreading for decades, but it first grabbed worldwide headlines in 2016. That February, with an outbreak sweeping the Americas, the World Health Organization (WHO) declared the surge in Zika-linked birth ...
15 hours ago
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Early nicotine vapor exposure increases nicotine seeking later in life, study finds
Nicotine vaping during adolescence may leave a lasting imprint on the brain's reward system, driving nicotine-seeking behavior well into adulthood even after long stretches without any exposure, according to new research ...
3 hours ago
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Senegal-made sickle cell treatment raises hopes, reduces costs
Mamadou Tahirou is 18 but looks more like a 12-year-old. His frame is frail from the ravages of sickle cell disease, which one Senegalese laboratory hopes to attenuate with affordable drug production.
16 hours ago
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Clear Eyes eye drops recalled nationwide over sterility concerns
Nearly 40,000 bottles of a widely sold eye drop are being pulled from shelves nationwide because the maker cannot guarantee the product is sterile.
21 hours ago
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New mRNA immunotherapy eliminates pancreatic tumors in mice
Inspired by the work of the RNA Therapeutics Institute at UMass Chan Medical School and the development of the COVID vaccine, Marcus Ruscetti, Ph.D., and Chaitanya Naimesh Parikh, Ph.D. '26, have developed an immunotherapy ...
Aug 25, 2026
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New oral nanomedicine boosts effectiveness of cancer immunotherapies
Immune checkpoint blockade is a form of cancer treatment that works by releasing the natural brakes on the immune system, allowing T cells to find and destroy cancer cells. Although it has transformed cancer immunotherapy, ...
Aug 25, 2026
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Small-molecule inhibitors shown to promote robust antitumor immunity
Researchers in Purdue University's College of Pharmacy have developed and validated a new series of small-molecule inhibitors that promote antitumor immunity and hold promise as anticancer agents.
Aug 24, 2026
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How well do COVID antivirals actually work? Not as well as we thought
If you're 70 or older, or 50 or older with underlying health conditions, and have tested positive for COVID, you might have been offered free or subsidized antivirals.
Aug 24, 2026
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Weight loss drugs may offer a new avenue for bipolar disorder research
Glucagon-like peptide 1 receptor agonists (GLP-1RA), commonly used to treat diabetes and weight loss, may have additional mental health benefits, especially for people with bipolar disorder, new Griffith University research ...
Aug 24, 2026
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Illicit fentanyl use is more than double medical use in US
The largest study to date to quantify and compare medical and illicit fentanyl use in the United States suggests that illicit use is more than twice as common as medical use.
Aug 24, 2026
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How much of a cancer drug is too much? Patients, researchers challenge FDA-approved dosages
Northwestern University economist Chuck Manski studies decision-making amid uncertainty. That prepared him better than many other cancer patients to decide whether to stay on an immunotherapy treatment that was making him ...
Aug 24, 2026
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New drug targets offer potential pathway for pancreatic cancer treatment
Peter Mac researchers have identified potential new drug targets for pancreatic cancer by uncovering proteins cancer cells rely on to grow and survive.
Aug 24, 2026
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New CDK strategies could target tumor growth by shutting down key gene activity
Cancer is the second-leading cause of death in Germany. In the search for new therapeutic approaches that target the uncontrolled growth of tumor cells, a class of enzymes known as cyclin-dependent kinases (CDKs) has come ...
Aug 24, 2026
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Smart probiotics can sense high blood sugar and release GLP-1 on demand
For people living with diabetes, managing blood sugar can mean constantly watching the clock, keeping meals and medications on schedule and staying alert to changes in glucose levels. While little can be done about timed ...
Officials warn wildland firefighters about the risks of using a supplement for smoke exposure
Fire and medical officials have issued warnings about a supplement offered to Western wildland firefighters who have been exposed to toxic chemicals while battling some of the country's biggest blazes.
Aug 23, 2026
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Study suggests new antibody therapy for tick-borne disease
Crimean-Congo hemorrhagic fever virus (CCHFV) is a dangerous virus spread by ticks. It transmits Crimean-Congo hemorrhagic fever (CCHF), a serious disease that has been spreading into new regions worldwide. Capable of killing ...
Aug 22, 2026
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Oral therapy protected mice from lethal radiation while sparing cancer treatment
Researchers at the Fralin Biomedical Research Institute at VTC have developed an experimental oral therapy that protected mice from otherwise harmful radiation exposure while preserving radiation's ability to destroy cancer ...
Aug 22, 2026
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More than 2,300 psilocybin users report real-world outcomes in Oregon and Colorado
Over the past few decades, some psychiatrists and medical researchers have been running controlled clinical trials to assess the potential therapeutic value of psychedelics, substances that alter perception, mood and thinking ...
Promising new weight loss and diabetes treatment helps burn fat while keeping muscle in preclinical study
Over the past five years, medications called GLP-1s have revolutionized the treatment of metabolic disorders like obesity, diabetes and fatty liver disease. Sold under the brand names Ozempic, Wegovy, Mounjaro and Zepbound, ...
Aug 21, 2026
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New drug combination may help treat advanced prostate cancer
About 1 in 8 men are diagnosed with prostate cancer during their lifetime. Although many survive, it can develop into metastatic disease.
Aug 21, 2026
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Super-resolution microscopy reveals how a cancer drug triggers cellular breakdown
Cancer drugs are often designed to block specific molecular targets, but what happens after they enter a cell is not always well understood. A new study published in Biophotonics Discovery demonstrates how advanced imaging ...
Aug 21, 2026
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