News tagged with animal model

Related topics: mouse model · cancer cells · nerve cells · proceedings of the national academy of sciences · cells

Finding liver cancer early and reversing its course

Liver cancer is often lethal in humans because it is diagnosed in late stages, but new work in animal models has identified a potential diagnostic biomarker of the disease and a potential way to reverse the damage done. The ...

Apr 21, 2015
popularity9 comments 0

Caring for blindness: A new protein in sight?

Vasoproliferative ocular diseases are responsible for sight loss in millions of people in the industrialised countries. Many patients do not currently respond to the treatment offered, which targets a specific factor, VEGF. ...

Apr 21, 2015
popularity18 comments 0

Omega-3 hope for cancer patients

The chemistry involved in designing drugs with the potential to treat cancer is complex and finicky. The placement of a single atom can be the difference between a cancer killer and a useless bystander. And that's just at ...

Apr 21, 2015
popularity7 comments 1

A new mouse model for the study of neurofibromatosis

The research group of the neurofibromatosis of the Catalan Institute of Oncology (ICO), the Institute of Biomedical Research of Bellvitge (IDIBELL) and the Institute of Medicicina Predictive and Personalized Cancer (IMPPC) ...

Apr 16, 2015
popularity16 comments 0

Animal model

An animal model is a non-human animal that has a disease or injury that is similar to a human condition. These test conditions are often termed as animal models of disease. The use of animal models allows researchers to investigate disease states in ways which would be inaccessible in a human patient, performing procedures on the non-human animal that imply a level of harm that would not be considered ethical to inflict on a human.

In order to serve as a useful model, a modeled disease must be similar in etiology (mechanism of cause) and function to the human equivalent. Animal models are used to learn more about a disease, its diagnosis and its treatment. For instance, behavioral analogues of anxiety or pain in laboratory animals can be used to screen and test new drugs for the treatment of these conditions in humans. A 2000 study found that animal models predicted human toxicity in 71% of cases, with 63% for nonrodents alone and 43% for rodents alone.

Animal models of disease can be spontaneous (naturally occurring in animals), or be induced by physical, chemical or biological means. For example,

The increase in knowledge of the genomes of non-human primates and other mammals that are genetically close to humans is allowing the production of genetically engineered animal tissues, organs and even animal species which express human diseases, providing a more robust model of human diseases in an animal model.

Animal models observed in the sciences of psychology and sociology are often termed animal models of behavior.

In quantitative genetics, the term animal model is used to refer to statistical models in which phenotypic variance is compartmentalised into environmental, genetic and sometimes maternal effects. Such animal models are also known as "mixed models".

This text uses material from Wikipedia, licensed under CC BY-SA

Subscribe to rss feed