News tagged with metabolic stress
Cancer suppressor gene links metabolism with cellular aging
The tumor suppressor protein p53 is an attractive target for drug developers. But this path has so far proven difficult, as most p53 regulatory proteins operate via protein-protein interactions, which make for poor drug targets, ...
Cancer
Jan 13, 2013 |
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Researchers identify new target for common heart condition
Researchers have found new evidence that metabolic stress can increase the onset of atrial arrhythmias, such as atrial fibrillation (AF), a common heart condition that causes an irregular and often abnormally fast heart rate. ...
Cardiology
Jan 08, 2013 |
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Scientists identify molecular process in fat cells that influences stress and longevity
As part of their ongoing research investigating the biology of aging, the greatest risk factor for type 2 diabetes and other serious diseases, scientists at Joslin Diabetes Center have identified a new factor—microRNA ...
Medical research
Sep 26, 2012 |
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Treatment target for diabetes, Wolfram syndrome
Inflammation and cell stress play important roles in the death of insulin-secreting cells and are major factors in diabetes. Cell stress also plays a role in Wolfram syndrome, a rare, genetic disorder that ...
Inflammatory disorders
Aug 07, 2012 |
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Surprising culprits behind cell death from fat and sugar overload
Excess nutrients, such as fat and sugar, don't just pack on the pounds but can push some cells in the body over the brink. Unable to tolerate this "toxic" environment, these cells commit suicide.
Medical research
Jul 05, 2011 |
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Discovery spurred by unique twist of fate
(Medical Xpress)—As people age, or as a result of poor nutrition, heart valves can become damaged by the accumulation of calcium deposits within the tissue. This calcification causes a thickening and hardening ...
Cardiology
Feb 21, 2013 |
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Stem cell survival strategy key to blood and immune system health
Stem cells of the aging bone marrow recycle their own molecules to survive and keep replenishing the blood and immune systems as the body ages, researchers at UC San Francisco (UCSF) have discovered.
Medical research
Feb 14, 2013 |
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Diabetes drug could hold promise for lung cancer patients
Ever since discovering a decade ago that a gene altered in lung cancer regulated an enzyme used in therapies against diabetes, Reuben Shaw has wondered if drugs originally designed to treat metabolic diseases ...
Cancer
Jan 29, 2013 |
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Liver mitochondria improve, increase after chronic alcohol feeding in mice
(Medical Xpress)—Scientists at the Keck School of Medicine of the University of Southern California (USC) have found evidence that liver mitochondria in mice adapt to become better metabolizers of alcohol and increase in ...
Medical research
Dec 21, 2012 |
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Stress during pregnancy leads to abdominal obesity in mice offspring
A new report involving mice suggests that a relationship exists between maternal metabolic or psychological stress and the development of obesity, type 2 diabetes, and metabolic syndrome in her offspring. What's more, the ...
Obstetrics & gynaecology
Jul 31, 2012 |
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Genetic variant is linked to obesity and insulin resistance
A large study in people at risk of diabetes has found a direct association between the presence of a small genetic alteration in a hormone receptor and increased body fat and insulin resistance. The results, to be presented ...
Genetics
Jun 26, 2012 |
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How aging normal cells fuel tumor growth and metastasis
It has long been known that cancer is a disease of aging, but a molecular link between the two has remained elusive.
Cancer
Jun 14, 2012 |
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Key enzyme plays roles as both friend and foe to cancer
A molecule thought to limit cell proliferation also helps cancer cells survive during initial tumor formation and when the wayward cells spread to other organs in the body, researchers at the University of ...
Medical research
Jun 14, 2012 |
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Why getting healthy can seem worse than getting sick
A new article in The Quarterly Review of Biology helps explain why the immune system often makes us worse while trying to make us well.
Immunology
Mar 20, 2012 |
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Explaining heart failure as a cause of diabetes
Either heart failure or diabetes alone is bad enough, but oftentimes the two conditions seem to go together. Now, researchers reporting in the January Cell Metabolism appear to have found the culprit that leads from heart ...
Diseases, Conditions, Syndromes
Jan 03, 2012 |
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