News tagged with oncogene

New factor to control oncogene-induced senescence

An article published on the journal Nature describes the major role that Pyruvate dehydrogenase (PDH) —an enzyme of cellular energy metabolism— plays in the regulation of the cellular senescence induce ...

May 21, 2013
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Genetic master controls expose cancers' Achilles' heel

In a surprising finding that helps explain fundamental behaviors of normal and diseased cells, Whitehead Institute scientists have discovered a set of powerful gene regulators dubbed "super-enhancers" that control cell state ...

Apr 11, 2013
popularity 4.8 / 5 (6) | comments 0 | with audio podcast

Some cancer mutations slow tumor growth

A typical cancer cell has thousands of mutations scattered throughout its genome and hundreds of mutated genes. However, only a handful of those genes, known as drivers, are responsible for cancerous traits ...

Feb 04, 2013
popularity 5 / 5 (1) | comments 0 | with audio podcast

Patients with EGFR exon 20 insertions have poorer prognosis

Exon 20 insertions are the third most common family of epidermal growth factor receptor (EGFR) mutations found in non–small-cell lung cancer (NSCLC). Little is known about cancers harboring these mutations aside from their ...

Jan 15, 2013
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