Minimum information guidelines to avoid an identity crisis in 3D cell cultures
The increased predictive power of 3D cell culture-based drug development may contribute to a decrease in animal use and a higher success rate of drugs in clinical trials. This is what makes these 3D cell cultures so attractive from ethical and economic perspectives.
Ghent University has developed a method to better compare these 3D cell cultures between labs. Interpretation of data between labs sometimes goes wrong because certain essential data is missing. Ghent University solves this by giving the 3D cell cultures a unique identity card that contains the essential information of such a cell culture. That unique identity card can now be exchanged between different researchers.
The results of this groundbreaking research have been published in the leading journal Nature Methods.
More information: Arne Peirsman et al, MISpheroID: a knowledgebase and transparency tool for minimum information in spheroid identity, Nature Methods (2021). DOI: 10.1038/s41592-021-01291-4
Journal information: Nature Methods
Provided by Ghent University