Neuroscience

Exploring hypothalamic circuits, one neuron at a time

A collaborative team from UConn Storrs and The Jackson Laboratory for Genomic Medicine characterized neuron diversity in the lateral hypothalamic area (LHA), a critical coordinator of fundamental behaviors in the brain. Using ...

Neuroscience

A peek into the interplay between sleep and wakefulness

Sleep is an autonomic process and is not always under our direct, voluntary control. Awake or asleep, we are basically under the regulation of two biological processes: sleep homeostasis, commonly known as 'sleep pressure', ...

Medical research

Obese inducing brain mechanism

Leptin is an adipocyte-derived hormone that stimulates hypothalamic neurons to strongly inhibit food intake. Leptin signaling in the hypothalamus, a part of the mid-brain, thus plays a crucial role in the regulation of body ...

Medical research

A metabolic switch to turn off obesity

You've tried all the diets. No matter: you've still regained the weight you lost, even though you ate well and you exercised regularly! This may be due to a particular enzyme in the brain: the alpha/beta hydrolase domain-6 ...

Medical research

Neurons controlling appetite made from skin cells

Researchers have for the first time successfully converted adult human skin cells into neurons of the type that regulate appetite, providing a patient-specific model for studying the neurophysiology of weight control and ...

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