News tagged with regulatory proteins
One step closer to understanding biology behind genetic variants linked to blood cell traits
(Medical Xpress)—Researchers at the Wellcome Trust Sanger Institute and University of Cambridge have unpicked genetic variants that affect the formation of blood cells. They found that around a third of ...
Genetics
Apr 17, 2013 |
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'RNA sponge' mechanism may cause ALS/FTD neurodegeneration
The most common genetic cause of both ALS (amyotrophic lateral sclerosis) and FTD (frontotemporal dementia) was recently identified as an alteration in the gene C9orf72. But how the mutation causes neurodegenerative disease ...
Genetics
Apr 01, 2013 |
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Same signaling enzymes can trigger two different processes in the cell
Stroke, heart attacks and numerous other common disorders result in a massive destruction of cells and tissues called necrosis. It's a violent event: As each cell dies, its membrane ruptures, releasing substances that trigger ...
Immunology
Mar 18, 2013 |
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Team finds general mechanism that accelerates tumor development
ICREA professor Raúl Méndez publishes a study in Nature describing how the CPBE1 protein "takes the brakes off" the production of proteins associated with the cell switch from being healthy to tumorous. ...
Cancer
Feb 24, 2013 |
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Lack of iron regulating protein contributes to high blood pressure of the lungs
A protein known to regulate iron levels in the body has an unexpectedly important role in preventing a form of high blood pressure that affects the lungs, and in stabilizing the concentration of red cells ...
Medical research
Feb 14, 2013 |
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Cancer suppressor gene links metabolism with cellular aging
The tumor suppressor protein p53 is an attractive target for drug developers. But this path has so far proven difficult, as most p53 regulatory proteins operate via protein-protein interactions, which make for poor drug targets, ...
Cancer
Jan 13, 2013 |
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Search for epigenetic decoder leads scientists to Rett Syndrome
(Medical Xpress)—A few years ago, scientists discovered an unexpected layer of information woven into the genetic code – a nucleotide called 5-hydroxymethylcytosine, or 5hmC. Its meaning was unknown at the time, but a ...
Medical research
Dec 21, 2012 |
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Proteins that work at the ends of DNA could provide cancer insight
(Medical Xpress)—New insights into a protein complex that regulates the very tips of chromosomes could improve methods of screening anti-cancer drugs.
Medical research
Nov 29, 2012 |
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Adult stem cells change their epigenome to generate new organs
A study developed by researchers at the IDIBELL, led by Manel Esteller, has identified epigenetic changes that occur in adult stem cells to generate different tissues of the human body.
Medical research
Oct 02, 2012 |
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Putting a 'HEX' on muscle regeneration
A complex genetic regulatory network mediates the regeneration of adult skeletal muscles. In this issue of the Journal of Clinical Investigation, researchers at the State University of New York Downstate Medical Center in Bro ...
Medical research
Oct 01, 2012 |
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Fragile X study offers new drug hope
(Medical Xpress)—An experimental drug can improve sociability in patients with fragile X syndrome and may be helpful as a treatment for autism, according to a study.
Autism spectrum disorders
Sep 24, 2012 |
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Epigenetics emerges powerfully as a clinical tool
A study coordinated by Manel Esteller, published in Nature Reviews Genetics, highlights the success of this area of research to predict the behavior and weaknesses of tumors.
Genetics
Sep 12, 2012 |
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New regulatory mechanism discovered in cell system for eliminating unneeded proteins
A faulty gene linked to a rare blood vessel disorder has led investigators to discover a mechanism involved in determining the fate of possibly thousands of proteins working inside cells.
Medical research
Aug 10, 2012 |
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Two proteins offer a 'clearer' way to treat Huntington's disease
In a paper published in the July 11 online issue of Science Translational Medicine, researchers at the University of California, San Diego School of Medicine have identified two key regulatory proteins critic ...
Neuroscience
Jul 11, 2012 |
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Probing the roots of depression by tracking serotonin regulation at a new level
In a process akin to belling an infinitesimal cat, scientists have managed to tag a protein that regulates the neurotransmitter serotonin with tiny fluorescent beads, allowing them to track the movements of ...
Neuroscience
Jun 28, 2012 |
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