Study identifies new targets in the angiogenesis process

blood vessel
Credit: Pixabay/CC0 Public Domain

Angiogenesis is a process of new vessel formation that is activated both in physiological (tissue repair, reproduction, etc.) and pathological (myocardial infarction, diabetic retinopathy, cancer, etc.) conditions. The process is carried out by endothelial cells and includes their proliferation, migration and arrangement in tubes. Angiogenesis regulation is precise and is mainly mediated by pro-angiogenic factors, such as vascular endothelial growth factor (VEGF), which in turn promote different signaling pathways leading to an increase of intracellular Ca2+ concentrations.

The researchers from the Cardiovascular Pathophysiology group at the Institute of Biomedicine of Seville (IBiS) focused on precisely this point, demonstrating that the inhibition of certain proteins involved in the pathway's regulation drastically affects the proper development of blood vessels. Specifically, these researchers demonstrated, for the first time, the involvement of SARAF, a SOCE , and Orai1, a subunit that forms the pore of the SOCE channel, in the VEGF-mediated activation of . Likewise, the research group has shown the importance of this Ca2+ pathway in the formation of new vessels and in the development of retinal vascularisation in neonatal mice.

Thus, Orai1 and SARAF can be viewed as targets for the design of therapeutic strategies that could control angiogenesis in pathological situations such as cancer or retinopathies, or physiological situations such as post-infarction cardiac neovascularisation.


Explore further

A newly identified mechanism can be targeted to boost angiogenesis

More information: Isabel Galeano-Otero et al, SARAF and Orai1 Contribute to Endothelial Cell Activation and Angiogenesis, Frontiers in Cell and Developmental Biology (2021). DOI: 10.3389/fcell.2021.639952
Citation: Study identifies new targets in the angiogenesis process (2021, April 16) retrieved 16 October 2021 from https://medicalxpress.com/news/2021-04-angiogenesis.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
3 shares

Feedback to editors