HbA1c more than 5.9 percent can ID diabetes in early pregnancy

HbA1c ≥5.9 percent can ID diabetes in early pregnancy

(HealthDay)—An HbA1c threshold of ≥5.9 percent can identify all women with gestational diabetes in early pregnancy, according to a study published online Sept. 4 in Diabetes Care.

Ruth C.E. Hughes, M.B.B.Ch., from the University of Otago in New Zealand, and colleagues analyzed data from a group of women who completed an early oral glucose tolerance test (OGTT) and HbA1c tests. Pregnancy outcome data were also assessed.

In 16,122 women, HbA1c was measured at a median of 47 days' gestation. Twenty-three percent of those offered (974 women) took an early OGTT, and in this subset all 15 cases of diabetes were identified with HbA1c ≥5.9 percent. For before 20 weeks this threshold was 98.4 percent specific (positive predictive value, 52.9 percent). Excluding the women referred for , women with HbA1c of 5.9 to 6.4 percent had poorer pregnancy outcomes than those with HbA1c <5.9 percent (8,174 women): relative risk of major congenital anomaly was 2.67; pre-eclampsia, 2.42; shoulder dystocia, 2.47; and perinatal death, 3.96.

"HbA1c measurements were readily performed in contrast to the low uptake of early OGTTs," the authors write.


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Journal information: Diabetes Care

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Citation: HbA1c more than 5.9 percent can ID diabetes in early pregnancy (2014, September 16) retrieved 18 October 2019 from https://medicalxpress.com/news/2014-09-hba1c-percent-id-diabetes-early.html
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