Researcher invents chemo delivery system that minimizes impact on healthy cells

July 23, 2015 by Allison Gerrard, Dalhousie University
Dr. Naga Puvvada (left), a postdoctoral fellow at Dalhousie Medicine New Brunswick (DMNB) and  DMNB’s Dr. Keith Brunt (right). July 2015

A researcher at Dalhousie Medical School has developed a new way to deliver chemotherapy drugs. Using nanotechnology, the novel system releases chemo in cancerous cells only, leaving healthy cells alone. The work was recently published in Nature's Scientific Reports.

Dr. Naga Puvvada, a postdoctoral fellow at Dalhousie Medicine New Brunswick (DMNB), created the drug delivery system. He worked in collaboration with DMNB's Dr. Keith Brunt and researchers in the United States and India.

The research team designed a nano-particle that increases the amount of delivered to a tumour, and releases chemo only once inside . This minimizes the impact on healthy tissue.

Only with the high level of acidity created by tumours does the nano-particle become activated – it then enters the cancerous cell and breaks open. As the nano-particle releases its chemotherapy, it undergoes a colour change, known as photo-switching. This photo-switching enables researchers to determine how much of the chemo has been released and can be used to identify the presence of tumours.

"What 's unique about our design is the potential clinical translatability of our fluorescent photo-switching, as it could help determine the amount of chemotherapy being released," says Dr. Puvvada. "We still have some work to do before this is used in the clinic as the fluorescence is not currently picked up by MRIs or CTs. This is one of the next steps in our research."

While the research was based on human , it has the potential to be applied to any solid tumour.

"This new delivery system, while it is in its early stages, is promising for patient-tailored therapy in personalized medicine," says Dr. Brunt, assistant professor in the Department of Pharmacology. "The potential to improve the quality of life for solid tumour cancer patients and their overall outcomes is within reach with this type of targeted, measurable treatment."

More information: "Novel ZnO hollow-nanocarriers containing paclitaxel targeting folate-receptors in a malignant pH-microenvironment for effective monitoring and promoting breast tumor regression." Scientific Reports 5, Article number: 11760 DOI: 10.1038/srep11760

Journal information: Scientific Reports

Provided by Dalhousie University