February 17, 2016

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Heart arrhythmia drug may fight plaque buildup in blood vessels

Human heart. Credit: copyright American Heart Association
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Human heart. Credit: copyright American Heart Association

New research in mice provides convincing evidence that digoxin, a drug prescribed to treat atrial fibrillation, can help protect against atherosclerosis.

Investigators found that decreased the levels of total cholesterol, triglycerides and LDL-cholesterol by 41%, 54%, and 20%, respectively, in mice treated with high-dose digoxin compared with control mice.

The findings are published in the British Journal of Pharmacology.

More information: Huairui Shi et al. Digoxin reduces atherosclerosis in apolipoprotein E-deficient mice, British Journal of Pharmacology (2016). DOI: 10.1111/bph.13453

Journal information: British Journal of Pharmacology

Provided by Wiley

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