Tumor-specific pathway identified

November 22, 2011

A research team led by UT Southwestern Medical Center scientists has identified an atypical metabolic pathway unique to some tumors, possibly providing a future target for drugs that could reduce or halt the spread of cancer.

Dr. Ralph DeBerardinis, senior author of the study published Nov. 20 in Nature, likened the newly discovered pathway to traffic that is rerouted during a highway construction project.

"If we hone in on this reverse pathway, then we may be able to prevent the growth of certain ," said Dr. DeBerardinis, assistant professor of pediatrics and a physician scientist in the Eugene McDermott Center for Human Growth and Development. "It's long been thought that targeting tumor-specific would lead to an effective way to treat cancer. This is one of the few metabolic pathways that may actually exist specifically in tumors."

The pathway involves the Krebs cycle, a series of that generates energy and is considered one of the most familiar and widely studied processes in biology. In the normal cycle, energy is derived by the breakdown of from ingested carbohydrates, fats and proteins into carbon dioxide and water.

For more than 70 years, biology textbooks have depicted the Krebs cycle as running clockwise in . UT Southwestern researchers found that in some tumors the cycle runs in reverse.

The discovery is the latest milestone in a long line of scientific inquiry that began in the 1920s when biochemists first recognized metabolic differences between cancer cells and normal cells. Scientists since have thought they could stop the growth of with drugs that only tumor-specific pathways, leaving normal cells unaffected.

Researchers have identified only a few such therapeutic windows, the latest of which appears to be the reverse Krebs cycle pathway identified by Dr. DeBerardinis and colleagues in this investigation.

"There is no pathway that has been more extensively studied over the years than the Krebs cycle," Dr. DeBerardinis said. "The fact that with relatively modest manipulation, it can run in reverse is incredibly fascinating."

Dr. James K.V. Willson, director of the Harold C. Simmons Comprehensive Cancer Center, said the findings are significant.

"We are learning that certain cancers have previously unrecognized mutations in genes controlling metabolism – and these abnormalities are providing new therapeutic opportunities," he said.

Explore further: Scientists discover new pathway to potential therapies for advanced prostate cancer

Related Stories

Recommended for you

Elephants provide big clue in fight against cancer

October 9, 2015

Carlo Maley spends his time pondering pachyderms—and cactuses and whales, and a wide array of non-human species—all in pursuit of the answer to this question: Why do some life forms get cancer while others do not?

Compound doubles up on cancer detection

October 8, 2015

Tagging a pair of markers found almost exclusively on a common brain cancer yields a cancer signal that is both more obvious and more specific to cancer, according to a study published last week in the Proceedings of the ...


Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.