This article has been reviewed according to Science X's editorial process and policies. Editors have highlighted the following attributes while ensuring the content's credibility:

fact-checked

trusted source

proofread

Some brain tumors may be linked to head injury, mouse study suggests

Some brain tumors may be linked to head injury, mouse study suggests
a Nf1OPG mice undergo optic nerve crush (ON-CR) at 6 weeks of age, while optic nerves are analyzed at 12 weeks of age. Nf1OPG mice following ON-CR have increased b optic nerve volumes and exhibit increased c proliferation , d %Olig2+ cells and e %Blbp+ cells f 12-week-old Nf1f/R1809C; hGFAP-Cre mice following optic nerve crush at 6 weeks of age exhibit increased g optic nerve volumes h proliferation i %Olig2+ cells and j %Blbp+ cells compared to those undergoing a sham operation. Credit: Acta Neuropathologica Communications (2024). DOI: 10.1186/s40478-024-01735-w

A study in mice by researchers at the School of Medicine indicates that brain injury can lead to brain tumors in susceptible individuals. For this study, they used mice that model people with neurofibromatosis type 1 (NF1), a genetic disorder that causes brain tumors.

The study showed that molecules released by injured neurons set off events that create an environment primed for tumors to appear.

Senior author David H. Gutmann, MD, Ph.D., the Donald O. Schnuck Family Professor, Terrance Kummer, MD, Ph.D., an associate professor of neurology, and first author Jit Chatterjee, a senior scientist, found that injury caused existing brain tumors, called optic gliomas, in one strain of NF1 mice to grow faster.

In addition, they showed that a different strain of NF1 mice—one that does not normally develop —formed optic gliomas after either optic nerve injury or traumatic .

Importantly, this study also revealed how nerve injury creates conditions permissive for optic glioma formation and identified ways to interrupt this process.

"Injury creates environmental signals that might allow a cell that's poised to become a tumor to complete the process," Gutmann said.

The findings are available online in Acta Neuropathologica Communications.

More information: Jit Chatterjee et al, Brain injury drives optic glioma formation through neuron-glia signaling, Acta Neuropathologica Communications (2024). DOI: 10.1186/s40478-024-01735-w

Citation: Some brain tumors may be linked to head injury, mouse study suggests (2024, May 9) retrieved 20 July 2024 from https://medicalxpress.com/news/2024-05-brain-tumors-linked-injury-mouse.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.

Explore further

Epilepsy drug prevents brain tumors in mice with neurofibromatosis type 1

0 shares

Feedback to editors