Neuroscience

Cancer-like metabolism makes brain grow

The size of the human brain increased profoundly during evolution. A certain gene that is only found in humans triggers brain stem cells to form a larger pool of stem cells. As a consequence, more neurons can arise, which ...

Medical research

Metabolic adaptation ensures survival of colon cancer cells

Colon cancer cells deficient in p53, one of the most important control proteins in cell growth, activate a particular metabolic pathway to adapt to the lack of oxygen and nutrients inside the tumor. Statins, which are often ...

Oncology & Cancer

New screening method identifies inhibitors of cancer cell metabolism

A new screening system developed by scientists at the UCLA Jonsson Comprehensive Cancer Center leverages redundancy in an important component of a cell—nucleotide metabolism—to help identify new drugs that specifically ...

Medical research

Deciphering pancreatic cancer's invade and evade tactics

Two known gene mutations induce pathways that enhance pancreatic cancer's ability to invade tissues and evade the immune system. Researchers report the molecular details of this process, providing insights into druggable ...

Diabetes

New insight into the biology of insulin release

In a new study, Yale researchers challenge a long-held assumption about how insulin-producing cells in the pancreas sense and respond to glucose. Their findings could lead to changes in the way that scientists approach the ...

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