Colitis in test mice responds to treatment with human umbilical cord-derived mensenchymal cells

April 23, 2012

When laboratory mice were modeled with colitis and treated with human umbilical cord-derived mesenchymal cells, the cells homed in on the inflamed colon and effectively ameliorated colitis, reported a study published in a recent issue of Cell Transplantation (20:9), now freely available online.

According to study corresponding author Dr. Zhong Chao Han of the Institute of Hematology, Chinese Academy of Sciences and Peking Union of Medical Sciences, Crohn's disease and are two forms of inflammatory bowel diseases with uncertain etiologies. Their study was designed to determine if human umbilical cord-derived mesenchymal cells (hUC-MSCs) would be therapeutic when transplanted to test mice modeled with acute colitis.

"Emerging data has shown that MSCs have broad and potent immunosuppressive activities," said Dr. Han. "Our study found that systematic administration of hUC-MSCs effectively attenuated the clinical and pathological severity of the induced colitis by several disease parameters, including body weight loss and infiltration of ."

Colitis was induced in the test animals by use of trinitrobenzene sulfonic acid (TNBS), which was found to induce high levels of pro-inflammatory cytokines. However, the increased expression of cytokines interleukin (IL)-23 and IL-17 was "significantly reversed by hUC-MSC infusion."

"Although our study demonstrated that hUC-MSCs could inhibit the acute inflammatory process, the effect of the same treatment on is an unknown and should be investigated," said Dr Han.

Additionally, the researchers reported that once the hUC-MSCs migrated to the inflamed colon, they remained there for several weeks, indicating to the researchers that the hUC-MSCs were not only "responsive to the cues sent by the injured colon tissues" but were also "well tolerated, even in the xeno-transplantation setting."

"Considering that hUC-MSCs can be readily isolated with no harm to donors and subsequently expanded rapidly in large quantities, they provide an excellent choice for future clinical applications," concluded Dr. Han and the study's co-authors.

"This study provides preliminary evidence that umbilical cord derived mesenchymal stem cells acutely reduces the inflammation that causes colitis," said Dr. Shinn-Zong Lin, professor of Neurosurgery and superintendent at the China Medical University Hospital of Taichung, Taiwan. "The next step will be to see if long term benefit can also be demonstrated".

Explore further: Umbilical cord blood-derived stem cells studied for lupus therapy

More information: Liang, L.; Dong, C.; Chen, X.; Fang, Z.; Xu, J.; Liu, M.; Zhang, X.; Gu, D. S.; Wang, D.; Du, W.; Zhu, D.; Han, Z. C. Human umbilical cord mesenchymal stem cells ameliorate mice trinitrobenzene sulfonic acid (TNBS)-induced colitis. Cell Transplant. 20(9):1395-1408; 2011.

Provided by: Cell Transplantation Center of Excellence for Aging and Brain Repair

shares

Related Stories

Novel cytokine protects mice from colitis

August 23, 2011

Inflammatory bowel disease (IBD), which affects more than 1 million patients in North America, results from an uncontrolled immune response triggered by environmental factors, such as bacteria, in people genetically predisposed ...

Recommended for you

We've all got a blind spot, but it can be shrunk

August 31, 2015

You've probably never noticed, but the human eye includes an unavoidable blind spot. That's because the optic nerve that sends visual signals to the brain must pass through the retina, which creates a hole in that light-sensitive ...

Biologists identify mechanisms of embryonic wound repair

August 31, 2015

It's like something out of a science-fiction movie - time-lapse photography showing how wounds in embryos of fruit flies heal themselves. The images are not only real; they shed light on ways to improve wound recovery in ...

New 'Tissue Velcro' could help repair damaged hearts

August 28, 2015

Engineers at the University of Toronto just made assembling functional heart tissue as easy as fastening your shoes. The team has created a biocompatible scaffold that allows sheets of beating heart cells to snap together ...

Research identifies protein that regulates body clock

August 26, 2015

New research into circadian rhythms by researchers at the University of Toronto Mississauga shows that the GRK2 protein plays a major role in regulating the body's internal clock and points the way to remedies for jet lag ...

Fertilization discovery: Do sperm wield tiny harpoons?

August 26, 2015

Could the sperm harpoon the egg to facilitate fertilization? That's the intriguing possibility raised by the University of Virginia School of Medicine's discovery that a protein within the head of the sperm forms spiky filaments, ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.