Inflammatory disorders

Two new studies evaluate agents for treating ulcerative colitis

In the first clinical trial to evaluate two biologic therapies for moderate to severe ulcerative colitis (UC) head to head, Mount Sinai researchers found vedolizumab to be superior to adalimumab in a variety of measures. ...

Diseases, Conditions, Syndromes

Risk for developing idiopathic pulmonary fibrosis up in IBD

Patients with inflammatory bowel disease (IBD), especially male patients, have an increased risk for development of idiopathic pulmonary fibrosis (IPF), according to a study published online Aug. 16 in the Journal of Gastroenterology ...

Diabetes

Type 2 diabetes risk up with inflammatory bowel disease

(HealthDay)—Patients with inflammatory bowel disease (IBD) have increased risk of type 2 diabetes, according to a study published online Aug. 5 in Clinical Gastroenterology and Hepatology.

Diseases, Conditions, Syndromes

The impacts of smoking on patients with ulcerative colitis

Because smokers are less likely to develop ulcerative colitis (UC), a type of inflammatory bowel disease, patients with UC may be tempted to start smoking to lessen their symptoms. Researchers found no beneficial effects ...

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Ulcerative colitis

Ulcerative colitis (Colitis ulcerosa, UC) is a form of inflammatory bowel disease (IBD). Ulcerative colitis is a form of colitis, a disease of the intestine, specifically the large intestine or colon, that includes characteristic ulcers, or open sores, in the colon. The main symptom of active disease is usually constant diarrhea mixed with blood, of gradual onset. Ulcerative colitis is, however, believed to have a systemic etiology that leads to many symptoms outside the intestine. Because of the name, IBD is often confused with irritable bowel syndrome ("IBS"), a troublesome, but much less serious, condition. Ulcerative colitis has similarities to Crohn's disease, another form of IBD. Ulcerative colitis is an intermittent disease, with periods of exacerbated symptoms, and periods that are relatively symptom-free. Although the symptoms of ulcerative colitis can sometimes diminish on their own, the disease usually requires treatment to go into remission.

Ulcerative colitis occurs in 35–100 people for every 100,000 in the United States, or less than 0.1% of the population. The disease tends to be more common in northern areas. Although ulcerative colitis has no known cause, there is a presumed genetic component to susceptibility. The disease may be triggered in a susceptible person by environmental factors. Although dietary modification may reduce the discomfort of a person with the disease, ulcerative colitis is not thought to be caused by dietary factors. Although ulcerative colitis is treated as though it were an autoimmune disease, there is no consensus that it is such. Treatment is with anti-inflammatory drugs, immunosuppression, and biological therapy targeting specific components of the immune response. Colectomy (partial or total removal of the large bowel through surgery) is occasionally necessary, and is considered to be a cure for the disease.

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