Risk of rupture increases with size of cerebral aneurysm

June 28, 2012
Risk of rupture increases with size of cerebral aneurysm
The natural course of unruptured cerebral aneurysms varies according to their size, location, and shape, according to a study published in the June 28 issue of the New England Journal of Medicine.

(HealthDay) -- The natural course of unruptured cerebral aneurysms varies according to their size, location, and shape, according to a study published in the June 28 issue of the New England Journal of Medicine.

Akio Morita, M.D., Ph.D., from the NTT Medical Center Tokyo, and colleagues analyzed data on 5,720 patients (mean age, 62.5 years; 68 percent women) with newly identified, saccular aneurysms that were 3 mm or more in the largest dimension.

The researchers found that 91 percent of the 6,697 aneurysms were discovered incidentally. Most aneurysms were in the middle cerebral arteries (36 percent) and the internal carotid arteries (34 percent), with a mean size of 5.7 ± 3.6 mm. During follow-up, 111 patients had documented ruptures (annual rate of rupture, 0.95 percent), with the risk of rupture increasing with the increasing size of the aneurysm. With aneurysms that were 3 to 4 mm in size as the reference, the hazard ratios for rupture with increasing size were as follows: 5 to 6 mm, 1.13 (95 percent confidence interval [CI], 0.58 to 2.22); 7 to 9 mm, 3.35 (95 percent CI, 1.87 to 6.00); 10 to 24 mm, 9.09 (95 percent CI, 5.25 to 15.74); and 25 mm or larger, 76.26 (95 percent CI, 32.76 to 177.54). Also more likely to rupture were aneurysms with an irregular protrusion of the wall of the aneurysm (hazard ratio, 1.63; 95 percent CI, 1.08 to 2.48).

"This study showed that the natural course of unruptured cerebral varies according to the size, location, and shape of the aneurysm," the authors write.

One author disclosed financial ties to the biopharmaceutical and medical equipment industries.

More information: Full Text (subscription or payment may be required)

Related Stories

Psoriasis tied to 14 other autoimmune diseases

June 15, 2012

(HealthDay) -- Patients with psoriasis have significantly higher odds for having at least one of 14 other autoimmune diseases, according to a study published online June 4 in the Journal of the American Academy of Dermatology.

Recommended for you

Viruses thrive in big families, in sickness and in health

August 5, 2015

The BIG LoVE (Utah Better Identification of Germs-Longitudinal Viral Epidemiology) study, led by scientists at the University of Utah School of Medicine, finds that each bundle of joy puts the entire household at increased ...

Experimental MERS vaccine shows promise in animal studies

July 28, 2015

A two-step regimen of experimental vaccines against Middle East respiratory syndrome (MERS) prompted immune responses in mice and rhesus macaques, report National Institutes of Health scientists who designed the vaccines. ...

Can social isolation fuel epidemics?

July 21, 2015

Conventional wisdom has it that the more people stay within their own social groups and avoid others, the less likely it is small disease outbreaks turn into full-blown epidemics. But the conventional wisdom is wrong, according ...

Lack of knowledge on animal disease leaves humans at risk

July 20, 2015

Researchers from the University of Sydney have painted the most detailed picture to date of major infectious diseases shared between wildlife and livestock, and found a huge gap in knowledge about diseases which could spread ...

IBD genetically similar in Europeans and non-Europeans

July 20, 2015

The first genetic study of inflammatory bowel disease (IBD) to include individuals from diverse populations has shown that the regions of the genome underlying the disease are consistent around the world. This study, conducted ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.