Risk of rupture increases with size of cerebral aneurysm

Risk of rupture increases with size of cerebral aneurysm
The natural course of unruptured cerebral aneurysms varies according to their size, location, and shape, according to a study published in the June 28 issue of the New England Journal of Medicine.

(HealthDay) -- The natural course of unruptured cerebral aneurysms varies according to their size, location, and shape, according to a study published in the June 28 issue of the New England Journal of Medicine.

Akio Morita, M.D., Ph.D., from the NTT Medical Center Tokyo, and colleagues analyzed data on 5,720 patients (mean age, 62.5 years; 68 percent women) with newly identified, saccular aneurysms that were 3 mm or more in the largest dimension.

The researchers found that 91 percent of the 6,697 aneurysms were discovered incidentally. Most aneurysms were in the middle cerebral arteries (36 percent) and the internal carotid arteries (34 percent), with a mean size of 5.7 ± 3.6 mm. During follow-up, 111 patients had documented ruptures (annual rate of rupture, 0.95 percent), with the risk of rupture increasing with the increasing size of the aneurysm. With aneurysms that were 3 to 4 mm in size as the reference, the hazard ratios for rupture with increasing size were as follows: 5 to 6 mm, 1.13 (95 percent confidence interval [CI], 0.58 to 2.22); 7 to 9 mm, 3.35 (95 percent CI, 1.87 to 6.00); 10 to 24 mm, 9.09 (95 percent CI, 5.25 to 15.74); and 25 mm or larger, 76.26 (95 percent CI, 32.76 to 177.54). Also more likely to rupture were aneurysms with an irregular protrusion of the wall of the aneurysm (hazard ratio, 1.63; 95 percent CI, 1.08 to 2.48).

"This study showed that the natural course of unruptured cerebral varies according to the size, location, and shape of the aneurysm," the authors write.

One author disclosed financial ties to the biopharmaceutical and medical equipment industries.

More information: Full Text (subscription or payment may be required)

add to favorites email to friend print save as pdf

Related Stories

Psoriasis tied to 14 other autoimmune diseases

Jun 15, 2012

(HealthDay) -- Patients with psoriasis have significantly higher odds for having at least one of 14 other autoimmune diseases, according to a study published online June 4 in the Journal of the American Ac ...

Aneurysms don't occur earlier in second generation

Feb 23, 2009

People whose parents or aunts and uncles have had a brain aneurysm are more likely to have one themselves, indicating that genetic risk factors passed down by generation are responsible. Prior studies had suggested that ...

Recommended for you

Oral contraceptive equal to antibiotics for acne care

3 hours ago

(HealthDay)—At six months, oral contraceptive pills (OCPs) are comparable to systemic antibiotics for acne management, according to a review published in the September issue of the Journal of the American Ac ...

Photodynamic therapy vs. cryotherapy for actinic keratoses

4 hours ago

Photodynamic therapy (PDT, which uses topical agents and light to kill tissue) appears to better clear actinic keratoses (AKs, a common skin lesion caused by sun damage) at three months after treatment than cryotherapy (which ...

US official warns Ebola outbreak will get worse

6 hours ago

A third top doctor has died from Ebola in Sierra Leone, a government official said Wednesday, as a leading American health official warned that the outbreak sweeping West Africa would get worse before it ...

UN releases $1.5mn to help DR Congo fight Ebola

8 hours ago

The United Nations on Wednesday allocated $1.5 million (1.1 million euros) to help the Democratic Republic of Congo fight Ebola, just days after the country confirmed its first cases this year.

User comments