Risk of rupture increases with size of cerebral aneurysm

Risk of rupture increases with size of cerebral aneurysm
The natural course of unruptured cerebral aneurysms varies according to their size, location, and shape, according to a study published in the June 28 issue of the New England Journal of Medicine.

(HealthDay) -- The natural course of unruptured cerebral aneurysms varies according to their size, location, and shape, according to a study published in the June 28 issue of the New England Journal of Medicine.

Akio Morita, M.D., Ph.D., from the NTT Medical Center Tokyo, and colleagues analyzed data on 5,720 patients (mean age, 62.5 years; 68 percent women) with newly identified, saccular aneurysms that were 3 mm or more in the largest dimension.

The researchers found that 91 percent of the 6,697 aneurysms were discovered incidentally. Most aneurysms were in the middle cerebral arteries (36 percent) and the internal carotid arteries (34 percent), with a mean size of 5.7 ± 3.6 mm. During follow-up, 111 patients had documented ruptures (annual rate of rupture, 0.95 percent), with the risk of rupture increasing with the increasing size of the aneurysm. With aneurysms that were 3 to 4 mm in size as the reference, the hazard ratios for rupture with increasing size were as follows: 5 to 6 mm, 1.13 (95 percent confidence interval [CI], 0.58 to 2.22); 7 to 9 mm, 3.35 (95 percent CI, 1.87 to 6.00); 10 to 24 mm, 9.09 (95 percent CI, 5.25 to 15.74); and 25 mm or larger, 76.26 (95 percent CI, 32.76 to 177.54). Also more likely to rupture were aneurysms with an irregular protrusion of the wall of the aneurysm (hazard ratio, 1.63; 95 percent CI, 1.08 to 2.48).

"This study showed that the natural course of unruptured cerebral varies according to the size, location, and shape of the aneurysm," the authors write.

One author disclosed financial ties to the biopharmaceutical and medical equipment industries.

More information: Full Text (subscription or payment may be required)

add to favorites email to friend print save as pdf

Related Stories

Psoriasis tied to 14 other autoimmune diseases

Jun 15, 2012

(HealthDay) -- Patients with psoriasis have significantly higher odds for having at least one of 14 other autoimmune diseases, according to a study published online June 4 in the Journal of the American Ac ...

Aneurysms don't occur earlier in second generation

Feb 23, 2009

People whose parents or aunts and uncles have had a brain aneurysm are more likely to have one themselves, indicating that genetic risk factors passed down by generation are responsible. Prior studies had suggested that ...

Recommended for you

Evidence-based recs issued for systemic care in psoriasis

5 hours ago

(HealthDay)—For appropriately selected patients with psoriasis, combining biologics with other systemic treatments, including phototherapy, oral medications, or other biologic, may result in greater efficacy ...

Bacteria in caramel apples kills at least four in US

6 hours ago

A listeria outbreak believed to originate from commercially packaged caramel apples has killed at least four people in the United States and sickened 28 people since November, officials said Friday.

Steroid-based treatment may answer needs of pediatric EoE patients

6 hours ago

A new formulation of oral budesonide suspension, a steroid-based treatment, is safe and effective in treating pediatric patients with eosinophilic esophagitis (EoE), according to a new study in Clinical Gastroenterology and Hepatology, the official clinical practice journal ...

Discovery of genes that predispose a severe form of COPD

8 hours ago

A study by Ramcés Falfán-Valencia, researcher at the National Institute of Respiratory Diseases (INER), found that the mestizo Mexican population has a number of variations in certain genes that predispose ...

On the environmental trail of food pathogens

10 hours ago

Tracking one of the deadliest food contamination organisms through produce farms and natural environments alike, Cornell microbiologists are showing how to use big datasets to predict where the next outbreak could start.

User comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.