Risk of rupture increases with size of cerebral aneurysm

June 28, 2012
Risk of rupture increases with size of cerebral aneurysm
The natural course of unruptured cerebral aneurysms varies according to their size, location, and shape, according to a study published in the June 28 issue of the New England Journal of Medicine.

(HealthDay) -- The natural course of unruptured cerebral aneurysms varies according to their size, location, and shape, according to a study published in the June 28 issue of the New England Journal of Medicine.

Akio Morita, M.D., Ph.D., from the NTT Medical Center Tokyo, and colleagues analyzed data on 5,720 patients (mean age, 62.5 years; 68 percent women) with newly identified, saccular aneurysms that were 3 mm or more in the largest dimension.

The researchers found that 91 percent of the 6,697 aneurysms were discovered incidentally. Most aneurysms were in the middle cerebral arteries (36 percent) and the internal carotid arteries (34 percent), with a mean size of 5.7 ± 3.6 mm. During follow-up, 111 patients had documented ruptures (annual rate of rupture, 0.95 percent), with the risk of rupture increasing with the increasing size of the aneurysm. With aneurysms that were 3 to 4 mm in size as the reference, the hazard ratios for rupture with increasing size were as follows: 5 to 6 mm, 1.13 (95 percent confidence interval [CI], 0.58 to 2.22); 7 to 9 mm, 3.35 (95 percent CI, 1.87 to 6.00); 10 to 24 mm, 9.09 (95 percent CI, 5.25 to 15.74); and 25 mm or larger, 76.26 (95 percent CI, 32.76 to 177.54). Also more likely to rupture were aneurysms with an irregular protrusion of the wall of the aneurysm (hazard ratio, 1.63; 95 percent CI, 1.08 to 2.48).

"This study showed that the natural course of unruptured cerebral varies according to the size, location, and shape of the aneurysm," the authors write.

One author disclosed financial ties to the biopharmaceutical and medical equipment industries.

Explore further: The contraceptive pill and HRT may protect against cerebral aneurysm

More information: Full Text (subscription or payment may be required)

Related Stories

The contraceptive pill and HRT may protect against cerebral aneurysm

May 5, 2011
Women who develop cerebral aneurysms are less likely to have taken the oral contraceptive pill or hormone replacement therapy, suggesting taking oestrogen could have a protective effect, reveals research published in the ...

Psoriasis tied to 14 other autoimmune diseases

June 15, 2012
(HealthDay) -- Patients with psoriasis have significantly higher odds for having at least one of 14 other autoimmune diseases, according to a study published online June 4 in the Journal of the American Academy of Dermatology.

New device offers revolutionary treatment for difficult-to-Treat brain aneurysms

June 8, 2011
Physicians at Rush University Medical Center are offering a new and effective treatment to patients suffering from complex brain aneurysms. The recently FDA-approved technology called the Pipeline Embolization Device (PED ...

Recommended for you

How hepatitis C hides in the body

October 13, 2017
The Hepatitis C (HCV) virus is a sly enemy to have in one's body. Not only does it manage to make itself invisible to the immune system by breaking down communication between the immune cells, it also builds secret virus ...

Largest study yet of malaria in Africa shows historical rates of infection

October 12, 2017
(Medical Xpress)—A team of researchers with members from the Kenya Medical Research Institute, the University of Oxford and the University of KwaZulu-Natal has conducted the largest-ever study of the history of malaria ...

Promising new target for treatment of psoriasis is safe, study shows

October 11, 2017
A protein known to play a significant role in the development of psoriasis can be prevented from functioning without posing a risk to patients, scientists at King's College London have found.

Norovirus evades immune system by hiding out in rare gut cells

October 11, 2017
Noroviruses are the leading cause of non-bacterial gastroenteritis in the world and are estimated to cause 267 million infections and 20,000 deaths each year. This virus causes severe diarrhea, nausea, and stomach pain.

Research reveals how rabies can induce frenzied behavior

October 11, 2017
Scientists may finally understand how the rabies virus can drastically change its host's behavior to help spread the disease, which kills about 59,000 people annually.

Experimental Ebola vaccines elicit year-long immune response

October 11, 2017
Results from a large randomized, placebo-controlled clinical trial in Liberia show that two candidate Ebola vaccines pose no major safety concerns and can elicit immune responses by one month after initial vaccination that ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.